Structure of PDB 8hkz Chain AS4E Binding Site BS01

Receptor Information
>8hkz Chain AS4E (length=240) Species: 330779 (Sulfolobus acidocaldarius DSM 639) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VHITRFEAPWFLKVGKKEYKWIIRSRAGPHKIQESVPLAILLKYYLKAVD
TTREAKRIIFDGKVLVDGKVRRDYKYPVGLMDVVEIPSADLRVRIIPDNV
RYLTTINISREDAKYKFVRIMNKTTLKSGVLQLNLEDGRNILLKGEELSQ
YNLPTLTTLKIELPEQKITTAYTIKEGVYAMIIGGRNAGLHGKISKIQLA
KYKRIKYSLVTLEGKDGSTFQTNLINVMAIGENEADSNLG
Ligand information
>8hkz Chain A16S (length=1493) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auuccgguugauccugccggacccgaccgcuaucgggguagggauaagcc
augggagucuuacacucccggguaagggaguguggcggacggcugaguaa
cacguggcuaaccuacccucgggacggggauaaccccgggaaacugggga
uaauccccgauagggaaggaguccuggaaugguuccuucccuaaagggcu
auaggcuauuucccguuuguagccgcccgaggauggggcuacggcccauc
aggcugucggugggguaaaggcccaccgaaccuauaacggguaggggccg
uggaagcgggagccuccaguugggcacugagacaagggcccaggcccuac
ggggcgcaccaggcgcgaaacguccccaaugcgcgaaagcgugagggcgc
uaccccgagugccuccgcaggaggcuuuuccccgcucuaaaaaggcgggg
gaauaagcggggggcaagucuggugucagccgccgcgguaauaccagcuc
cgcgaguggucggggugauuacugggccuaaagcgccuguagccggccca
ccaagucgccccuuaaaguccccggcucaaccggggaacugggggcgaua
cuggugggcuagggggcgggagaggcgggggguacucccggaguaggggc
gaaauccuuagauaccgggaggaccaccaguggcggaagcgccccgcuag
aacgcgcccgacggugagaggcgaaagccggggcagcaaacgggauuaga
uaccccgguagucccggcuguaaacgaugcgggcuaggugucgaguaggc
uuagagccuacucggugccgcagggaagccguuaagcccgccgccugggg
aguacggucgcaagacugaaacuuaaaggaauuggcgggggagcaccaca
agggguggaaccugcggcucaauuggagucaacgccuggaaucuuaccgg
gggagaccgcaguaugacggccaggcuaacgaccuugccugacucgcgga
gaggaggugcauggccgucgccagcucguguugugaaauguccgguuaag
uccggcaacgagcgagacccccaccccuaguugguauucuggacuccggu
ccagaaccacacuagggggacugccggcguaagccggaggaaggaggggg
ccacggcaggucagcaugccccgaaacucccgggccgcacgcggguuaca
auggcagggacaacgggaugcuaccucgaaagggggagccaauccuuaaa
cccugccgcaguugggaucgagggcugaaacccgcccucgugaacgagga
aucccuaguaaccgcgggucaacaacccgcggugaauacgucccugcucc
uugcacacaccgcccgucgcuccacccgagcgagaaaggggugagguccc
uugcgauaagugggggaucgaacuccuuucccgcgaggggggagaagucg
uaacaagguagccguaggggaaccugcggcuggaucaccucau
...<<<<<.[.((((>>>>>.<<<<<<<<<.....<<<.<<......<<<
.<<<..<<<..<<<<<<<<......>>>>>>>>>>>......<<......
..<<<<<<...<<...<<<<<<<.<<<<<....<<<<<......>>>>>.
....>>>>>...<<<<<<<<..<<......>>.>>>>>>>>.....<<<<
<<<..............>>>>>>>.>>>>>>>..>>.>>>>>>.<<<...
.<<...<<<<<<<<.......>>>>>>>>.>>......>>>..<<<<<<<
<....>>>>...>>>>.>>.<<<<<............>>>>>.<<<<...
.>>>>...>>>>>>.........<<<....<<<<....>>>>..>>>..>
>..>>>....<<<<<<...>>>>>>...<<<<<<<.........>>>>>>
>.....<<<<<((......<<<<.....<<..))>>.......>>>>.>>
>>>..>>>>>>>>>..........<<<((.....<<<<...<<<.<<<<<
<<.<<<<<<<<<......<<<<<<<.....>>>>>>>....>>>>>>>..
>>>>>>>>>...<<<<<<.....<<<<<<<<<<.<<<<<<<....<<<..
....>>>.......>>>>>>>.>>>.......<<....>>.>>>>>>>..
..>>>.>>>...>>>...>>>>...<<<<<<<...<<...<<<<......
...>>>>...>>>>>>>>>.........<<<<<<..<<<<<<<<<<<<<<
.....>>>>>>>>>>>>>>...<<..))>>.....>>>>>>.>>>.<<<.
.....<<<<....>>>>....>>>..)))).]<<<<<.<<<<<<<..<<.
<<<<<<.<<<<<<<<<<<......<<........>>..........<<<<
<.....<<<<<.......<<<.<<<.......>>>.>>>....>.>>>>.
..<<.<<<..<<<<<<<<.....<<<<<<<<<....>>>..<<<<.....
.>>>>..>>>>>>....<<<<<.<<<<<<<..........<<<<....>>
>>.........>>>>>>.>....<<<<<....>>>>>........>>>>>
.....>>.>>>...>>>>>>>>......>>>>>...>>.>>>>>>>>.>.
..<<.<<<<.....<<...<<..<<<<....>>>>..>>....>>.....
>>>>.>>...........<<<<<<<........>>>>>>>..........
>>>>>>....<<<<<<<<.......>>>>>>>>......>>...>>>>>>
>>>>.>>....<..<<.<.<<<<.<<<..<<<.<<<<<<<<<..<<<<<<
<<<<.....>>>>>>>>>>..>>>>>>>>>.>>>..>>>.>>>>..>.>>
...>.....<<<<<<<<<....>>>>>>>>>............
Receptor-Ligand Complex Structure
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PDB8hkz Cryo-electron microscopy structure and translocation mechanism of the crenarchaeal ribosome.
Resolution4.78 Å
Binding residue
(original residue number in PDB)
V1 H2 F6 E7 K13 K17 Y19 W21 I22 I23 R24 R26 A27 G28 P29 K31 I32 R53 F60 R71 Y76 Y102 N122 K123 T125 L126 K127 S128 G129 L131 N134 G138 R139 N140 E165 Q166 G185 R186 K201 K203 R204 K206 F220 Q221
Binding residue
(residue number reindexed from 1)
V1 H2 F6 E7 K13 K17 Y19 W21 I22 I23 R24 R26 A27 G28 P29 K31 I32 R53 F60 R71 Y76 Y102 N122 K123 T125 L126 K127 S128 G129 L131 N134 G138 R139 N140 E165 Q166 G185 R186 K201 K203 R204 K206 F220 Q221
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8hkz, PDBe:8hkz, PDBj:8hkz
PDBsum8hkz
PubMed37604686
UniProtO05634|RS4E_SULAC Small ribosomal subunit protein eS4 (Gene Name=rps4e)

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