Structure of PDB 9bdn Chain AS23 Binding Site BS01

Receptor Information
>9bdn Chain AS23 (length=141) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKCRGLRTARKLRSHRRDQKWHDKQYKKAHLGTALKANPFGGASHAKGIV
LEKVGVEAKQPNSAIRKCVRVQLIKNGKKITAFVPNDGCLNFIEENDEVL
VAGFGRKGHAVGDIPGVRFKVVKVANVSLLALYKGKKERPR
Ligand information
>9bdn Chain A18S (length=1691) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucgacuuggauaacugugguaau
ucuagagcuaauacaugccgacgggcgcugacccccuucgcgggggggau
gcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacgc
ggcggcgacgacccauucgaacgucugcccuaucaacuuucgaugguagu
cgccgugccuaccauggugaccacgggugacggggaaucaggguucgauu
ccggagagggagccugagaaacggcuaccacauccaaggaaggcagcagg
cgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaaca
auacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaauc
cuuuaacgaggauccauuggagggcaagucuggugccagcagccgcggua
auuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcucgu
aguuggaucuugggagcggccguccccugcucggcgccggcccgaagcgu
uuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccgcag
cuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucggaac
ugaggccaugauuaagagggacggccgggggcauucguauugcgccgcua
gaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcauuug
ccaagaauguuuucauuaaucaagaacgaaagucggagguucgaagacga
ucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaugcgg
cggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagucuu
uggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauugac
ggaagggcaccaccaggaguggagccugcggcuuaauuugacucaacacg
ggaaaccucacccggcccggacacggacaggauugacagauugauagcuc
uuucucgauuccgugggugguggugcauggccguucuuaguugguggagc
gauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaacua
guuacgcgaccccggucggcguaacuucuuagagggacaaguggcguuca
gccacccgagauugagcaauaacaggucugugaugcccuuagauguccgg
ggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgcc
ggcaggcgcggguaacccguugaaccccauucgugauggggaucggggau
ugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaag
cuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacua
ccgauuggaugguuuagugaggcccucggaucggccccgccgggccuggc
ggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaaguc
guaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<........<<.....<<.<<<....
.>>>.>>......>>.........<<<<...<<<<<<....>>>>>>...
>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<<
.>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<<.
........>>>>>>>>>>......>>>...<<<.<<<<....>>>>....
>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>>>
>.........<<<....<<<<...>>>>..>>>..>...>>.>.....<<
<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<.........
..>..>>.........<<<<<((....<.<<<<.....<<..))>>....
...>>>>>>>>>>..>>>>>>.>>>.........<.<((.....<.<<..
.<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>>>.
<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>......
>.>>>..>>>........<.<<.<<<<<<<...............>>>>>
>>.>>.>....>>....<<<<<<..<...<<<<..<<..<<<<<<<<...
<<<......>>>......>>>>>>>>..>>.......<<....>>...>>
>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.
<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<
<<<.<<<<<....>>>>>>>>>>>.>..>>>...<<..))>>...>>...
..>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<<<<
<.<<<<<<<..<<..<<<<<..<<<.<<<<........<<........>>
..........<<<<<......<<<<<<.......<<.<<<........>>
>.>>.....>>>>>>.<.<<.<<<..<<.<<<<<<....<<<.<<<<<..
..>>>...<<<......>>>...>>.>>>....<<<...<...<<<<..<
<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<.....
>>>>>........>>>....>>>.>>>.....>>>>>>>>......>>>>
>......>>>>.>>>.....<<.<<<........<.......<<<.<<<<
....>>>>.>>>....>.........>>>.>>......<.....<<<<<.
.........>>>>>.....>.....>>>>>.....<<<<<<<<.......
>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.
<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<<<<<..>>>>>
>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>
>...>.....<<<<<<<<<<..>>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB9bdn Structural mechanism of angiogenin activation by the ribosome.
Resolution3.1 Å
Binding residue
(original residue number in PDB)
G2 K3 C4 R5 G6 L7 R8 T9 R11 K12 R17 R18 Q20 W22 H23 D24 K28 L36 A44 S45 H46 A47 K48 Q61 N63 S64 A65 I66 R67 K68 I75 K76 N87 D88 G104 G106 R107 K108 H110 V112 G113 D114 R119 S129 L131 Y134 K137
Binding residue
(residue number reindexed from 1)
G1 K2 C3 R4 G5 L6 R7 T8 R10 K11 R16 R17 Q19 W21 H22 D23 K27 L35 A43 S44 H45 A46 K47 Q60 N62 S63 A64 I65 R66 K67 I74 K75 N86 D87 G103 G105 R106 K107 H109 V111 G112 D113 R118 S128 L130 Y133 K136
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:9bdn, PDBe:9bdn, PDBj:9bdn
PDBsum9bdn
PubMed38718836
UniProtG1SZ47|RS23_RABIT Small ribosomal subunit protein uS12 (Gene Name=RPS23)

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