Structure of PDB 8ova Chain AS Binding Site BS01

Receptor Information
>8ova Chain AS (length=140) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKTNGQHAARKLVRLRRKNRWADKGWKKSHTFVAQKANPFGGSSHAKGIV
LEKIGVGAKQPNSAIRKCVRVQLIKNDKKIIAFVPNDGCLHFIEENDEVL
VSGFGRSGHAVGDIPGVRFKIVKVSSVGLYALYRQKKEKP
Ligand information
>8ova Chain AA (length=1919) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcauugcaggaaucugcgcauggcucauua
caucagacguaaucugccgccaaaauuuugcggcgcauuacuggauaacu
uggcgaaacgccaagcuaauacaugaaccaaucggacgcucucuuugaug
ggacguccagcgaaugaaugaaauuagaaccaacgccuccacccggaggc
aguaacacucagacguguugacucaauucauuccgugcgaaagccgagcu
gcucggcgucuacugacgaacaacugcccuaucagccagugauggccgug
uaguggacugccauggcguugacgggagcgggggauuaggguucgauucc
ggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcg
cgcaaauugcccaaugucgaaaaaauacgaugaggcagcgaaaagaaaua
gagccgaccgugugguuguuuucaaugggggauacucaaacccauucaau
aucgaguaacaauuggaggacaagucuggugccagcacccgcgguaauuc
cagcuccaaaagcguauauuaaugcuguugcuguuaaaggguucguaguu
gaacugugggccacguaguguggugccguaccagucccguccaccucgac
guguuuugacccacgcccucguggccagauacaagaaacacgggagcagu
ucgcaugucaugcaugggggcguccgugaauuuacugugaccaaaaagau
gcgaccaaagcagucuugccgacuugaauuacaaagcaugggauaacgaa
gcaucagcccugggguuauguugguuuuagaaguccuugggagauuaugg
ggccgcguuguuucguguggcgcgccgcggcuuccaggaaugaaggaggg
uaguucgggggagaacguacuggugcgucagaggugaaauucuuagaccg
caccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaau
caagaaccaaaguguggggaucaaagaugauuagagaccauuguagucca
cacugcaaaccaugacacccaugaauuggggaacaucauuuuauuuauca
auuuacgugccuacucagcacguuucuuacuucuucacgcgaaagcuugg
agguuacagucucaggggggaguacguucgcaagagugaaacuuaaagaa
auugacggaauggcaccacaagacguggagcgugcgguuuaauuugacuc
aacacggggaacuuuaccagauccggacagggugaggauugacagaugga
guguucuuucucgauccccugaaugguggugcauggccgcuuuuggucgg
uggagugauuuguuugguugauuccgucaacggacgagauccaagcugcc
caguaggugccgggauuguccacacaggacagcaguccucgucauccuuc
uuuuuucaggccccuucucugcgggauuccuugcuuuucgcgcaagguga
gauuuugggcaacagcaggucugugaugcuccucaauguucugggcgaca
cgcgcacuacaaugucagugagaacaagagcgacgcucccgcuugaucaa
aagagcggggaaaccacggaaucacguagacccacuugggaccgaguauu
gcaauuauuggucgcgcaacgaggaaugucucguaggcgcagcucaucaa
acugugccgauuacgucccugccauuuguacacaccgcccgucguuguuu
ccgaugauggugcaauacaggugaucggaccgucaccgaaaguucaccga
uauugcuucaauagaggaagcaaaagucguaacaagguagcuguagguga
accugcagcuggaucauuu
...<<<<<...{{{{>>>>>{{{{.[[[[[[...[[[..........[[[
.[[[..<<....<<....<<<<...>>>>...>>.>>......{{.....
...[[[..[[..[[...[[..{......<<<<.>>>>....<<.....<<
<<<<.....>>>>>>......>>..........<<<<<.<<<<<<.>>.>
>>>>>>>>.[[((((((((.....<<<<<<<<<<<<<<<......>>>>>
.........................))))))))...]]....<<<<<<<.
>>>>>>>...}..]]..]]]]..]]].<<<....<<<....<<<<<.<<.
......>>.>>>>>>>>......>>>..<<<.<<<<....>>>>....>>
>.}}.<<.<<<..........>>>.>>.<<<<<..>>>>>...]]]]]].
........<<<....<<<..........>>>..>>>.......]]]....
<<<...<.<.....>.>...>>>.....<.<..............>....
..>.........<<<<<((....<.<<<<.....<<..))>>.......>
>>>>>>>>>..]]]]]]}}}}.........[[[[[.....((((...(((
.......<<<<...<...<..<<....<<..<.<...........>.>..
>>..>>.>...>..>>>>.................<...<<........<
...<<<.......>>>.>...>>...>...<<..<...........<...
<<.......>>..<......>.......>..........>....>>....
.......[[..(((.....>>>>>>>>>>....)))..]]........<<
<<<<<<<....<<<..>.>>.....>>>>>>>>>.............<<<
<<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>......>>
>>>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....)))
...))))...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>
>>>>.........<<<.<<...<..<.<<<<<..................
......<<<<.......>>>>.>>>>>.>..>......<<..]]>>....
.>>.....>>>.]]].<<<......<<<<....>>>>....>>>..}}}}
..<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<....
....>>..........<<<<<.<....<<<<<........<<.<<<....
....>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<
<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.
....<<<.<<<<<<................................>>>.
........>>>.>>>.....>>>>....<<<<<<<....>.>>>>>>...
....>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.
>>>>>.>>.....<<<.<<<.......<...<....><<<<<<<......
..>>>>>>>....>........>>>...>>>......<....<<<.<<..
........>>.>>>.....>.....>>>>>>....<<<<<<<........
.>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<
<<..<<.<<<.<<<<<<..<<<<<.<...<.<<.>>.>...>.>>>>>..
>>>>>>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<...
.>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		T2 K3 T4 N5 G6 H8 R11 K12 R15 R17 R18 N20 W22 A23 K28 S44 S45 H46 K48 Q61 N63 S64 A65 R67 K68 N87 D88 G104 F105 R107 S108 G113 D114 R119 K124
Binding residue
(residue number reindexed from 1)		T1 K2 T3 N4 G5 H7 R10 K11 R14 R16 R17 N19 W21 A22 K27 S43 S44 H45 K47 Q60 N62 S63 A64 R66 K67 N86 D87 G103 F104 R106 S107 G112 D113 R118 K123
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ38CD1

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