Structure of PDB 8ova Chain AR Binding Site BS01

Receptor Information
>8ova Chain AR (length=89) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TIGTYNEEGVNVDLYIPRKCHATNSLITSFDHSAVQIAIANVDPNGVIDG
TTTTLCIAGYLRCQGESDHAINHLAIAKGIVRIKTGKKP
Ligand information
>8ova Chain AA (length=1919) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcauugcaggaaucugcgcauggcucauua
caucagacguaaucugccgccaaaauuuugcggcgcauuacuggauaacu
uggcgaaacgccaagcuaauacaugaaccaaucggacgcucucuuugaug
ggacguccagcgaaugaaugaaauuagaaccaacgccuccacccggaggc
aguaacacucagacguguugacucaauucauuccgugcgaaagccgagcu
gcucggcgucuacugacgaacaacugcccuaucagccagugauggccgug
uaguggacugccauggcguugacgggagcgggggauuaggguucgauucc
ggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcg
cgcaaauugcccaaugucgaaaaaauacgaugaggcagcgaaaagaaaua
gagccgaccgugugguuguuuucaaugggggauacucaaacccauucaau
aucgaguaacaauuggaggacaagucuggugccagcacccgcgguaauuc
cagcuccaaaagcguauauuaaugcuguugcuguuaaaggguucguaguu
gaacugugggccacguaguguggugccguaccagucccguccaccucgac
guguuuugacccacgcccucguggccagauacaagaaacacgggagcagu
ucgcaugucaugcaugggggcguccgugaauuuacugugaccaaaaagau
gcgaccaaagcagucuugccgacuugaauuacaaagcaugggauaacgaa
gcaucagcccugggguuauguugguuuuagaaguccuugggagauuaugg
ggccgcguuguuucguguggcgcgccgcggcuuccaggaaugaaggaggg
uaguucgggggagaacguacuggugcgucagaggugaaauucuuagaccg
caccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaau
caagaaccaaaguguggggaucaaagaugauuagagaccauuguagucca
cacugcaaaccaugacacccaugaauuggggaacaucauuuuauuuauca
auuuacgugccuacucagcacguuucuuacuucuucacgcgaaagcuugg
agguuacagucucaggggggaguacguucgcaagagugaaacuuaaagaa
auugacggaauggcaccacaagacguggagcgugcgguuuaauuugacuc
aacacggggaacuuuaccagauccggacagggugaggauugacagaugga
guguucuuucucgauccccugaaugguggugcauggccgcuuuuggucgg
uggagugauuuguuugguugauuccgucaacggacgagauccaagcugcc
caguaggugccgggauuguccacacaggacagcaguccucgucauccuuc
uuuuuucaggccccuucucugcgggauuccuugcuuuucgcgcaagguga
gauuuugggcaacagcaggucugugaugcuccucaauguucugggcgaca
cgcgcacuacaaugucagugagaacaagagcgacgcucccgcuugaucaa
aagagcggggaaaccacggaaucacguagacccacuugggaccgaguauu
gcaauuauuggucgcgcaacgaggaaugucucguaggcgcagcucaucaa
acugugccgauuacgucccugccauuuguacacaccgcccgucguuguuu
ccgaugauggugcaauacaggugaucggaccgucaccgaaaguucaccga
uauugcuucaauagaggaagcaaaagucguaacaagguagcuguagguga
accugcagcuggaucauuu
...<<<<<...{{{{>>>>>{{{{.[[[[[[...[[[..........[[[
.[[[..<<....<<....<<<<...>>>>...>>.>>......{{.....
...[[[..[[..[[...[[..{......<<<<.>>>>....<<.....<<
<<<<.....>>>>>>......>>..........<<<<<.<<<<<<.>>.>
>>>>>>>>.[[((((((((.....<<<<<<<<<<<<<<<......>>>>>
.........................))))))))...]]....<<<<<<<.
>>>>>>>...}..]]..]]]]..]]].<<<....<<<....<<<<<.<<.
......>>.>>>>>>>>......>>>..<<<.<<<<....>>>>....>>
>.}}.<<.<<<..........>>>.>>.<<<<<..>>>>>...]]]]]].
........<<<....<<<..........>>>..>>>.......]]]....
<<<...<.<.....>.>...>>>.....<.<..............>....
..>.........<<<<<((....<.<<<<.....<<..))>>.......>
>>>>>>>>>..]]]]]]}}}}.........[[[[[.....((((...(((
.......<<<<...<...<..<<....<<..<.<...........>.>..
>>..>>.>...>..>>>>.................<...<<........<
...<<<.......>>>.>...>>...>...<<..<...........<...
<<.......>>..<......>.......>..........>....>>....
.......[[..(((.....>>>>>>>>>>....)))..]]........<<
<<<<<<<....<<<..>.>>.....>>>>>>>>>.............<<<
<<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>......>>
>>>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....)))
...))))...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>
>>>>.........<<<.<<...<..<.<<<<<..................
......<<<<.......>>>>.>>>>>.>..>......<<..]]>>....
.>>.....>>>.]]].<<<......<<<<....>>>>....>>>..}}}}
..<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<....
....>>..........<<<<<.<....<<<<<........<<.<<<....
....>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<
<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.
....<<<.<<<<<<................................>>>.
........>>>.>>>.....>>>>....<<<<<<<....>.>>>>>>...
....>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.
>>>>>.>>.....<<<.<<<.......<...<....><<<<<<<......
..>>>>>>>....>........>>>...>>>......<....<<<.<<..
........>>.>>>.....>.....>>>>>>....<<<<<<<........
.>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<
<<..<<.<<<.<<<<<<..<<<<<.<...<.<<.>>.>...>.>>>>>..
>>>>>>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<...
.>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		H75 I78 R84 I85 K86 K89
Binding residue
(residue number reindexed from 1)		H73 I76 R82 I83 K84 K87
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ385B8

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