Structure of PDB 4v6i Chain AR Binding Site BS01

Receptor Information
>4v6i Chain AR (length=88) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTSKPAGFMKKLRAAKLAAPENEKPAPVRTHMRNMIIVPEMIGSVVGIYN
GKAFNQVEIRPEMLGHYLGEFSITYTPVRHGRAGATTS
Ligand information
>4v6i Chain CA (length=1721) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaaguuaagcca
ugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucau
uaaaucaguuaucguuuauuugauagacauggauaacugugguaauucua
gagcuaauacauguuaaaaucucgacccuuuggaagagauguauuuauua
gauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuuc
gaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuau
caacuuuaugguaggauaguggccuaccaugguuucaacggguaacgggg
aauaaggguucgauuccggagagggagccugagaaacggcuaccacaucc
aaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguag
ugacaauaaauaacgauacagggcccauucgggucuuguaauuggaauga
guacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugc
cagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugca
guuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuu
uucguguacuggauuuccaacgggguccuucuggcuaaccuugaguccuu
guggcucuuggcgaaccaguguucaaagcaggcguauugcucgaauauac
guuugguucuauuuuguugguuucuaggaccaucguaauggggacggucg
ggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaag
acuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaac
gaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccaua
aacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggc
accuuagagaaaucaaagucuuuggguucuggggggaguauggucgcaag
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacggggaaacucaccagguccagacacaaua
aggauugacagauugagagcucuuucuugauuuugugggugguggugcau
ggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaa
cgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccac
uucuuagagggacuaucgguuucaagccgauggaaguugaggcaauaaca
ggucugugaugcccuuaacguucugggcgcacgcgcgcuacacugacgga
gccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuc
cgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauu
ccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuug
uacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucag
gaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggac
aaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggu
gaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<<..<<<<<...<...........<<<.
<<<...<...<<.....<............>....>>>.......<<...
.....<<<..<<..<<...........<<<<.....<<.<<<.....>>>
.>>......>>>>.<.<<<.........>>>.>....<.<<<<[......
((...((..<..<.....>..>.............>.]..>>>.>.....
<..<<<<.<<<<.....>>>>>>>>>.........>>>>..>>>.<<<..
..<<<..<<<<<<<.........>>>>>>>>>>......>>>...<<<<<
<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<.
...>>.>...>>>>>>.......<.<<<...<<<<.....>>>.>>>>>.
.......>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......
..............................<<<<<((......<<<<...
..<<..))>>.......>>>>.>>>>>..>>>>>.>>>>.........<<
<[[.....<.<<...<<<..............<..<.....<..<..<..
...>..>...>..>...>.......<...<.<<.<.<...<<..<....>
..>>...>.>.>>.>...>.<<.....<..<......>..>.....>>.<
...<<<<<<<<.....))...)).>>>>>>>>..>......<<<<<.<<.
..<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.
>>>......<<<....>>>..>>>>..>>.>>>.>>....>>>...>>.>
....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>....
......<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>.
.>>>..<<.].]>>...>>.....>>>.>>>.<<<......<<<......
>>>....>>>..)))).]<<<<<.<<<<<<<...<..<<<<<..<<<.<<
<<<<......<..........>..........<<<<<........<<..<
<<....<<............>>........>>>..>>...<..<<<..<<
.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>
>......<<..<<<.<<<<..<<<<..<<<<<......>>>>>....>>>
>..>>>>>>>.....<<<<.......>>>>........>>......>>>.
>>>.....>>>>>.>......>>>>>..>>.>>>>.>>>.....<<<<<.
........<..........<<<....>>>..........>.........>
>>>>...........<<<<<<..........>>>>>>..........>>>
>>.....<<<<<<<<<.....>>>>>>>>>......>....>>>>>>>>>
>.>>.......<<.<..<<...<<....<<<<<<<<.<<<..<.<<....
..<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>......>>.>
..>>>.>>>>>>>>...>>...>>...>.>>.........<<<<<<<<<.
...>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v6i Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
Resolution8.8 Å
Binding residue
(original residue number in PDB)		F56 M57 K58 K59 E88 M89 I90 E106 I107 R108 Y123 P125 V126 G129 R130 A131 T135
Binding residue
(residue number reindexed from 1)		F8 M9 K10 K11 E40 M41 I42 E58 I59 R60 Y75 P77 V78 G81 R82 A83 T87
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000054 ribosomal subunit export from nucleus
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v6i, PDBe:4v6i, PDBj:4v6i
PDBsum4v6i
PubMed20980660
UniProtQ01855|RS15_YEAST Small ribosomal subunit protein uS19 (Gene Name=RPS15)

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