Structure of PDB 8fmw Chain AQ Binding Site BS01

Receptor Information

>8fmw Chain AQ (length=119) Species: 224326 (Borreliella burgdorferi B31)

MKKIKEAEQRKLRRKKRIKDKIGRGVASRPRITVFKSNRYFYAQVIDDSK
GHTIASISTIEKSLNLGKNIDDVKKLGEVLAKRLKEKNINNLIFDRNGYK
YHGLIASFATSLREFGINI

Ligand information

>8fmw Chain AA (length=2929)

uggucaaaguaauaagagucuauggugaaugccuaggagcuuuaaggcga
agaaggucgugguaagcugcgaaaagcuugggggagaagcaaacauuuau
ugaucccaagauuaccgaauggaguaauccagcuagcaagaugcuagcua
ucuauuauuuaaauaauagaggcgauaccaggggaagugaaccaucuaag
uacccugaggaaaagaaaucaaagagauucccuuaguaguggcgagcgaa
aagggaguagcccaaacuuuaaaugugucaagcugcagagcguugcauuu
augggguuguaggacguuuaggcuuagucuguaauaagcaaaaaaguuac
aaaauauuuauauagaagaauaaucuggaaaguuuaaccaaagaagguga
uaguccuguaauuuaaauguaaauaucuuuuuaaaauguuccugaguagg
acgaggcacgagaaaccuuguuugaagcuggggagaccacucuccaaggc
uaaauacuagaaagcuaccgauagagaagaguaccgugagggaaagguga
aaagaaccccgggaggggagugaaauagaacugaaaccguagacuuacaa
gcagucaaagccguaauuuauugcggugauggcgugccuuuugcauaaug
aaccugcgaguuaucaugucuagcaagauuaaagcauagaagugcuggag
ucgaagcgaaagcgagucuuaaaagggcgauuuaguuagaugugguagac
ccgaagccgagugaucuauuuauggccaggcugaagcuuggguaaaacca
aguggagggccgaacucuagucuguuuaaaaaggcagggaugagcuguga
auaggagugaaaggcuaaacaaacucggagauagcugguucuccccgaaa
uggauuuaaguucagccuuauuuuaguuuaauagagguagagcacuaauu
gagcuagggccugucaaaggguaccaaacucaguuaaacuccgaaugcua
uuaaaugaugaauaggagugagacuaugggcgauaagguucauagucgag
agggaaacaacccagaccaacagcuaaggucucaaaaauguguuaagugg
aaaaggagguuuagguacguaaacagccaggagguuggcuuagaagcagc
cauaccuuuaaagagugcguaauagcucacuggucgaguacuuaagcgcc
gauaauguaacggggcuaaacacauuaccgaagcuuuggaucuuaacgaa
aguuaagaugguaggggagcguucuguaagccagagaaguuaagcuggaa
aguuugauggagguaucagaagugagaaugcagguaugaguaacgaaaaa
augggugagauucccauucgccgaaaaccuaagguuuccuggguaaaggu
cgucuucccaggguuagucggccccuaaggcaaagcugaaaaguguaguc
gaugggaaacggguuaauauucccguaccucuuauaguuucgauggagug
acgcaugagguuaacuacugcuaggcgaugguuguccuaguuuaagcauu
aaggcgaugaucuuaauaggaaaauccguuaagagagcuaagaugugaug
augagugcuauuuagguagcaugaaauguagguagucaaggugccaagaa
auagcuucuaagguuaggcuauaagggaccguaccgcaaaccgacacagg
uaggugggaugaaaauucuaaggcgcgcgagagaauccacguuaaggaac
ucugcaaaauacguacguaacuucgggauaaguacgaccuaagcaauuag
guagcauaaaaaugguccaaacgacuguuuaccaaaaacacaggucucug
caaaucuguaaagagaaguauagggacugacaccugcccggugcuggaag
guuaagaggagauguuaguuuaugcgaagcauugaauuuaagccccagua
aacggcggccguaacuauaacgguccuaagguagcgaaauuccuugucgg
guaaguuccgacccgcacgaaugguguaacgauuuggacgcugucucaac
guggagcucggugaaauugaaguaucggugaagaugccgauuacuugugg
uuagacggaaagaccccgugaaccuuuacuauagcuugguauugagauuu
gauuaaauauguguaggauaggugggagacuuugaagcuaucucgucagg
gguaguggagucaaucuugaaauaccacccuuguuuaauuagguuucuaa
cuuauagaaauaugaggagagugccagguggguaguuugacuggggcggu
cgccuccuaaagaguaacggaggugcgcaaagguuaccuuagagugguug
gaaaucacucuguaaguguaaaggcauaagguagcuuaacuguaagacug
acaagucgaacagauacgaaaguaggucuuagugaucuggcgguggcaag
uggaagcgccgucacuuaacgaauaaaagguacuccggggauaacaggcu
uauccuucccaagaguucacaucgacggaaggguuuggcaccucgauguc
ggcucaucgcauccuagggcuggagcagguccuaaggguauggcuguucg
ccauuuaaagcgguacgcgagcuggguucagaacgucgugagacaguuug
gucccuaucugccacaagcguuggauauuugagaggagcuaucuuuagua
cgagaggaccgagauggacgaaccucuagugugccaguuauccugccaag
gguaagugcuggguagcuacguucggaaaggauaaccgcugaaagcaucu
aagugggaagccuuccucaagaugagauauccuuuaaggguccuggaaga
auaccagguugauagguuagaaguguaaguauagcaauauauuaagcuga
cuaauacuaauuacccguaucuuuggcca

.<<<<<<<<......<<<<<<<<<<<.....<<..<<<<<<<<.<<<<..
....<<<<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>..
...>>>>>>>...>>>....<<<....>>><<<<<<<.....>>>>>>>.
<<<<<<..<..>..>>>>>>.>>....<<<<<<.....<<....>>....
..>>>>>.>.........<<...>>..<<<<<<.....<<.....>>...
.>>>>>>..<<<....<<.<<<<<<<.......<<.<<<.....>>>>>>
>.>>.......<<<<.[....<<<<<.>>>.>>.>>>>>.<<<<......
..<.<<<<.<<<<.<<....<<<.<......>.>>>((......<<<...
..))>>>....>>...>>>>>>.>>>.>>>>...]..>>>>.......<<
<<<<<<.........>>>>>>>>......<<<<<..((((>>>>>..>>>
......>>..>>>>>>.>>..............<<....>>....>>...
......<<<<....>>>>.................>>>>>>>>>>>....
...<<<<..<<<<<<<<..>>>>>>>>..>>>>...<.<........>.>
.<<<<<<....<<<<<<<<<<<<<..<<<...<<<<<....>>>>>...>
>>...<<....>>..<<<<.....>>>>......>>>>>>>>>>>>>..<
<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>>>
>>>.....>>>...<<<<.<<<<........>>>>>>>>....>>>>>>>
>>...<<<.....>>>......>>>>>>...>..>.>>..<<<<<<....
<<<<<....>>>>><<<<<<<<<..<<<<<<<<<.....<<<...<<<<<
<<<...<<<<<<......>>>>.>>...>>>>>>>>..>>.>.....>>>
>>>>>>...>>>>>>>.>>..<<<<<<<<<<......>>>>>>>>>>...
.<<<......>>>...<<<<.<<<...<<<((....<<<<<<<.......
....<<..<<<<<<<<<<.......<<<<<.<<<..<<<.........>>
>...>>>.........<<......>>...>>>>>...>>>>>>>>>>.>>
............)).....>>>>>>>>>>...>>>>>>><<<<<<<<...
.>>>>>>>>....>>>>>><.<<<<<...<<<......<<<<<<<<....
>>>>>>>>...>>>..>>>>>..>.....>>>>>><......<<.....<
<<<<<.......>>>>>><<<<....<<<<<.<<<..<<<<<<...<<..
...>>.>>>>>>....((<<<.<<<...<<<...<<<....>>>...>>>
...>>>..<<<<<........>>>>>)).<<<<<<<<<.<<...<<<<<.
..<<<<..<<<...<<<<.<<<<<<...[[[[...>>>>>><<..<<<<<
..<<<......<<<<<............>>>>>...>>>..>>>>>...>
>...<<<<<<<....>>>>>>>.....>>>>...>>>...>>>>......
...>>>>>...>>....>>>>>>>>>..>>>.>>>.....<<......>>
>>>>>.<<<.......>>>..>>>>..<<<<....<<<<<<<<.<<....
.....<.....<<<<<.....<..>......>>>>><<<<<<....>>>>
>>............<<<<<<<<<..<<<.........>>>..<<<<<<<.
....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..<
<<<.<<<...<<<<<..<<....>>...>>>>>...>>>.>>>>>>>>>.
.>>>>><<<<<<.......>>>>>>........<...........<<<<<
<.....>>>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>
>>>>>.>>>>>>.....>.....<<<<<........>>>>>..<<<<<<<
<.<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<<<<<
<<<<<<<<<...........<<<<<..<<<......<<<<<<<<....>>
>>>>>>...>>>............>>>>>..>>>>>>>>>>>>>>>>...
<<<<<<....>>>>>>....>>>>>>>>>..>>>>>..<<<<.....>>>
><<<<<<...........>>>>>>..<<...<<<<<<<.<<<<<<<<...
....>>>>>>>>...<<.[.(((>>....>>>>>>>...<<<<..<<<<.
...>>>>..>>>>.<<<....>>>.>>)))]......<<<<<<<.<<..)
)))..>>>>>>>>>.............>>>>..>>>>>>.......<<<<
.<.<<<<<<...<<.......>>...>>>>>>...>>>>.>.......<<
<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.<<<<<.....>
>>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>.
...>>..>>>>>>>>>>>....<<<<<<<...<<<<<.<<<<<<<.....
..........>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>
>>>>...>>>>>...>>>>.>>>>>...<<<....<<<<<..........
.>>>>>....>>>>>>>>.......>>>>>>>.....<<<<<<<<<....
...>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..
>>>>>.>>>...>>>>....>>>>>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fmw The structure of a hibernating ribosome in a Lyme disease pathogen.
• Resolution: 2.86 Å
• Binding residue (original residue number in PDB): K2 K3 R10 R13 R14 K16 R17 D20 I22 F94 R96 Y101 R113 I119
• Binding residue (residue number reindexed from 1): K2 K3 R10 R13 R14 K16 R17 D20 I22 F94 R96 Y101 R113 I119

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008097 5S rRNA binding
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8fmw, PDBe:8fmw, PDBj:8fmw
• PDBsum: 8fmw
• PubMed: 37907464
• UniProt: O51447|RL18_BORBU Large ribosomal subunit protein uL18 (Gene Name=rplR)