Structure of PDB 8cqw Chain AQ Binding Site BS01

Receptor Information
>8cqw Chain AQ (length=91) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKRTKKVGITGKFGVRYGSSLRRQTKKLEVQQHAKYDCSFCGKRTVQRGA
TGIWNCKSCKKTVAGGAYTVSTAAAATVRSTIRRLRELAEA
Ligand information
>8cqw Chain 1 (length=3208) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuuugc
gguuuaccgggccagcaucgguuuggagcggcaggauaauggcggaggaa
uguggcacggcuucugcuguguguuauagccucugacgauacugccagcc
uagaccgaggacugcgguuaccuaggauguuggcauaaugaucuuaaguc
gcccgucuugaaacacggaccaaggagucuaacgucuaugcgaguguuug
gguguaaaacccguacgcguaaugaaagugaacgaaggugggggcccauu
agggugcaccaucgaccgauccugauguguucggauggauuugaguaaga
gcauagcuguugggacccgaaagauggugaacuaugccugaauaggguga
agccagaggaaacucugguggaggcucguagcgguucugacgugcaaauc
gaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucuagua
gcugguuccugccgaaguuucccucaggauagcagaagcucguaucaguu
uuaugagguaaagcgaaugauuagaagucuugggguugaaaugaccuuaa
cuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauugaac
guggacaauugaaugaagagcuuuuagugggccauuuuugguaagcagaa
cuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaugcacg
cucaucagacaccacaaaagguguuaguucaucuagacagccggacggug
gccauggaagucggaauccgcuaaggaguguguaacaacucaccggccga
augaacuagcccugaaaauggauggcgcucaagcgugcuacuuauacuuc
accgugauugcuguuuugacgcuuucacgaguaggcaggcguggagguca
gugacgaagccuuugcuguaaagcugggucgaacggccucuagugcagau
cuuggugguaguagcaaauauucaaaugagaacuuugaagacugaagugg
ggaaagguuccaugucaacagcaguuggacauggguuagucgauccuaag
agauggggaagcuccguuucaacgugcuugauuuuucaggccaaccaucg
aaagggaauccgguuaaaauuccggaacuuggauauggauucuucacggc
aacguaacugaauguggagacgucggcgugagcccugggaggaguuaucu
uuucuucuuaacagcuuaucacccuggaauugguuuauccggagaugggg
ucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcuuacg
acgguccuugaaaauccacaggaaggaauaguuuucaugccaagucguac
ucauaaccgcagcaggucuccaagguuaacagccucuaguugauagaaua
auguagauaagggaagucggcaaaauagauccguaacuucgggauaagga
uuggcucuaaggaucgguuuaacgaucaacuuagaacugguacggacaag
gggaaucugacugucuaauuaaaacauagcauugugauggucagaaagug
auguugacacaaugugauuucugcccagugcucugaaugucaaagugaag
aaauucaaccaagcgcggguaaacggcgggaguaacuaugacucucuuaa
gguagccaaaugccucgucaucuaauuagugacgcgcaugaauggauuaa
cgagauucccacugucccuaucuacuaucuagcgaaaccacagccaaggg
aacgggcuuggcagaaucagcggggaaagaagacccuguugagcuugacu
cuaguuugacauugugaaaagacauggaggguguagaauaagugggagcu
ucggccggugaaaccacuaccucuauaguuuuuuuacuuauucaaugaag
cggagcuggaggucaaacuccacguucuagcauuaagcccucugggcgau
ccggguugaagacauugucagguggggaguuuggcuggggcggcacaucu
guuaaacgauaacgcagguguccuaagggggacucauggagaacagaaau
cuccaguagaacaaaaggguaaaaguccccuugauuuugauuuucagugu
gaauacaaaccaugaaaguguggccuaucgauccuuuagucccucggaau
uugaggcuagaggugccagaaaaguuaccacagggauaacuggcuugugg
cagucaagcguucauagcgacauugcuuuuugauucuucgaugucggcuc
uuccuaucauaccgaagcagaauucgguaagcguuggauuguucacccac
uaauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuu
acccuacugaugaauguuaucgcaauaguaauugaacuuaguacgagagg
aaccguucauucagauaauugguuuuugcggcugucugaucaggcaacgc
cgcgaagcuaccaucugcuggauuauggcugaacgccucuaagucagaau
ccaugcuagaacgcgaugauuuuugcccugcacauuuuagauggauacga
auaagacuuuuuagucgcuggaccauagcaggcuggcaacggugcgcuua
gcggaaaggcuuugugcgcuugccggcggauagcaaugucaacaugcgcg
gggauaaauccuuugcauacgacuuagauguacaacggaguauuguaagc
aguagaguagccuuguuguuacgaucugcugagauuaagcucuuguuguc
ugauuugu
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>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]...............................
.<.<<....>>...>...........<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<..<....
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>>>>>>>........<<<.>>>.....>>>>>>>....>>>>>>>>>>>>
..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..<<
<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<<...
.>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>....
>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<...
.<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<........>>
>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>.
.>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<<.<<
<<<<<.....<<<....<<<....<<<<...<<<<<<.....>>>>>>.>
>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......>>>>
>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>>>>>
.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<<<<<
<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<<...
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>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>>>>>
>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<<<<.
<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>........
>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.....<<
<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<
<....<<<....>>>..........<<<<<<....>>>>>>......>>.
...>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<<<..
..>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{.
.>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>>>>>
>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>>>>>
.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>>..>
>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<...
..<<<<<<<.<<...............<<<<<....<....>.....>>>
>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>............
<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>
>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<.
...>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>....
....<...........<<<<<.......>>>>>.....>.....>>....
>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<..
......>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<
<<.<<<<<<<<..<<<<<<<<<<...<.<<....................
....................>>.>...>>>>>>>>>>...<<<<<.....
<<<<..<<<<<......>>>>>..............<<<<...>>>>..>
>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>>>..<<<<
<<...........>>>>>>..<<...<<<<<<<...<<<<<<.......>
>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<<.......
>>>>.>>>>.<<<....>>>.>>))).......((((((..((((.>>>>
>>))))))))))..........]]]]..}}]]]].......<<.<...<<
<<<<...<<.......>>...>>>>>>....>.>.>.......<<<<<.<
<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.........>>>.
....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}
..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<.............
....>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>>>>>..>>
>>>...>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>
>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<.....<<......
....<<<......>>>......>>.......<<<<<<...<<<<<<<..<
<<......>>>..>>>>>>>.>>>>>>..............>.>>>.>>>
>>>..<<<<<<<.............>>....<<<<<<<<<.<<<....<<
<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>>.>>>>>.
.>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cqw Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.05 Å
Binding residue
(original residue number in PDB)
T2 R4 T5 K6 K7 V8 G9 I10 G12 K13 F14 G15 V16 R17 Y18 G19 S20 S21 R23 H34 F41 C42 R49 A51 T52
Binding residue
(residue number reindexed from 1)
T1 R3 T4 K5 K6 V7 G8 I9 G11 K12 F13 G14 V15 R16 Y17 G18 S19 S20 R22 H33 F40 C41 R48 A50 T51
External links
PDB RCSB:8cqw, PDBe:8cqw, PDBj:8cqw
PDBsum8cqw
PubMed
UniProtA0A1D8PP14|RL43A_CANAL Large ribosomal subunit protein eL43 (Gene Name=RPL43A)

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