Structure of PDB 6xu8 Chain AQ Binding Site BS01

Receptor Information

>6xu8 Chain AQ (length=148) Species: 7227 (Drosophila melanogaster)

MQQKRREPVQAVQVFGRKKTATAVAYCKRGNGLLKVNGRPLEQIEPKVLQ
YKLQEPLLLLGKEKFAGVDIRVRVSGGGHVAQIYAIRQAISKALVAFYQK
YVDEASKKEIKDILVQYDRTLLVGDPRRCEPKKFGGPGARARYQKSYR

Ligand information

>6xu8 Chain B2 (length=1936)

auucugguugauccugccaguaguuauaugcuugucucaaagauuaagcc
augcaugucuaaguacacacgaauuaaaagugaaaccgcaaaaggcucau
uauaucaguuaugguuccuuagaucguuaacaguuacuuggauaacugug
guaauucuagagcuaauacaugcaauuaaaacaugaaccuuaugggacgu
gugcuuuuauuaggcuaaaaccaagcgaucgcaagaucguuauauugguu
gaacucuagauaacaugcagaucguauggucuuguaccgacgacagaucu
uucaaaugucugcccuaucaacuuuugaugguaguaucuaggacuaccau
gguugcaacggguaacggggaaucaggguucgauuccggagagggagccu
gagaaacggcuaccacaucuaaggaaggcagcaggcgcguaaauuaccca
cucccagcucggggagguagugacgaaaaauaacaauacaggacucauau
ccgaggcccuguaauuggaaugaguacacuuuaaauccuuuaacaaggac
caauuggagggcaagucuggugccagcagccgcgguaauuccagcuccaa
uagcguauauuaaaguuguugcgguuaaaacguucguaguugaacuugug
cuucauacggguaguauacuauaccuuuauguauguaagcguauuaccgg
uggaguucuuauaugugaucauauguuccuccuauuuaaaaaccugcauu
agugcucuuaaacgaguguuauugugggccgguacuauuacuuugaacaa
auuagagugcuuaaagcaggcuucaaaugccugaauauucugugcauggg
auaaugaaauaagaccucuguucugcuuucauugguuuucagaucaagag
guaaugauuaauagaagcaguuugggggcauuaguauuacgacgcgagag
gugaaauucuuggaccgucguaagacuaacuuaagcgaaagcauuugcca
aagauguuuucauuaaucaagaacgaaaguuagagguucgaaggcgauca
gauaccgcccuaguucuaaccauaaacgaugccagcuagcaauugggugu
agcuacuuuuauggcucucucagucgcuuccgggaaaccaaagcuuuuug
ggcuccgggggaaguaugguugcaaagcugaaacuuaaaggaauugacgg
aagggcaccaccaggaguggagccugcggcuuaauuugacucaacacggg
aaaacuuaccaggucgaacauaaguguguaagacagauugauagcucuuu
cucgaaucuaugggugguggugcauggccguucuuaguucguggagugau
uugucugguuaauuccgauaacgaacgagacucaaauauauuaaauagau
aucuucaggauuauggugcugaagcuuauguagccuucauuauuguguuu
gaauguguuuauguaaguggagccguaccuguugguuugucccauuauaa
ggacacuagcuucuuaaauggacaaauugcgucuagcaauaaugagauug
agcaauaacaggucugugaugcccuuagauguccugggcugcacgcgcgc
uacaaugaaaguaucaacguguauuuccuagaccgagagguccggguaaa
ccgcugaaccacuuucaugcuugggauugugaacugaaacuguucacgau
gaacuuggaauucccaguaagugugagucauuaacucgcauugauuacgu
cccugcccuuuguacacaccgcccgucgcuacuaccgauugaauuauuua
gugaggucuccggacgugaucacugugacgccuugcguguuacgguuguu
ucgcaaaaguugaccgaacuugauuauuuagaggaaguaaaagucguaac
aagguuuccguaggugaaccugcggaaggaucauua

...<<<<<.{.((((>>>>><<<<.<<<<<<...<.<<..<......<<<
.<<<..<<....<<....<<.........>>...>>.>>......<<...
.....<<<.<<<..<<....<<<<..............<<.....<<.<<
<.....>>>.>>......>>...........<<<<............>>>
>.<<..<<<<<.....(((...((..<<<<....>>>>........<...
.....>..>>>>>...>>...<...................>....>>>>
...>>>>>.>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>
>>>......>>>...<<<.<<<<....>>>>....>>>.>>.<<.<<<..
........>>>.>>.<.<<....>>.>...>>>>>>.........<<<..
..<<<.....>>>..>>>..>...>>.>.....<.<<<<<...<<<....
..>>>....>>>>..>.>.....<<.................>>......
...<<<<<((......<<<<.....<<..))>>.......>>>>.>>>>>
..>>>>>>>>>>.........<<<[[.....<<<<...<<<.<<.....<
<<<...<<......................>>....>>>>......<<..
..................................................
..............................>>....<<<<<<.<<.....
..<<...<.......>..<<<.......>>>....>>.......>>.>>.
.>>>>..........................))...)))...........
.......>>....<<<<..<.<<...<<<<..<<..<<<<<<<<...<<<
......>>>......>>>>>>>.>.>>.......<<....>>...>>>>.
..>>>.>.>>>...>>>...>>>>....<<<<<<<...<...<<<<.<..
...>.>>>>...>>>>>>>>..........<<<.<<.<<<.<<<<<<...
.<<<........>>>...>>>>>>.>>>...<<..]]>>...>>......
>>>.>>>.<<<......<<<......>>>....>>>..)))).}<<....
<<<<<<<..<<..<<<<<.<<<<.<<<<<<......<<........>>..
........<<<<......................<<<........>>>..
...............<<.<<<...<.<<<<<.....<<<.<.........
.....................>.>>>....<<<<..<<..<.<.......
.<.........<..<...................................
.......................>..>.......>...<<<<........
>>>>..........>.>.>>............................>>
>>.....>>.>>>.....>.>>>>>........>>>>...>>.>>>>.>>
>.>...<<<<<<..............<<<.<<<<....>>>>.>>>....
..........>>>>>>.........<<.....<..........>....>>
.........>>>>>.....<<<<<<<<.......>>>>>>>>......>>
...>>>>>>>....>>....<..<<.<..<<<<.<<....<<<<.<<<.<
<<..<<<<..<....<<<<.<<....<<<.........>>>.....>>..
>>>>....>..>>>>..>>>.>>>.>>>>...>>.>>>>...>.>>...>
.....<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6xu8 Ribosome heterogeneity in Drosophila melanogaster gonads through paralog-switching.
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): M1 Q2 R5 E7 V12 Q13 V14 F15 K19 T20 Y26 K28 N31 L33 K35 R39 P46 R71 R73 S75 G76 G77 G78 H79 V80 A81 Q82 R127 R128 C129 E130 P131 K132 K133 F134 G135 G136 G138 A139 R140 A141 R142 Y143 Q144 K145 S146 Y147 R148
• Binding residue (residue number reindexed from 1): M1 Q2 R5 E7 V12 Q13 V14 F15 K19 T20 Y26 K28 N31 L33 K35 R39 P46 R71 R73 S75 G76 G77 G78 H79 V80 A81 Q82 R127 R128 C129 E130 P131 K132 K133 F134 G135 G136 G138 A139 R140 A141 R142 Y143 Q144 K145 S146 Y147 R148

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022626 cytosolic ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6xu8, PDBe:6xu8, PDBj:6xu8
• PDBsum: 6xu8
• PubMed: 34283226
• UniProt: Q9W237|RS16_DROME Small ribosomal subunit protein uS9 (Gene Name=RpS16)