Structure of PDB 6xzr Chain AP1 Binding Site BS01

Receptor Information
>6xzr Chain AP1 (length=696) Species: 100673 (Influenza C virus (C/Johannesburg/1/66)) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKTFAEIAEAFLEPEAVRIAKEAVEEYGDHERKIIQIGIHFQVCCMFCDE
YLSTNGSDRFVLIEGRKRGTAVSLQNELCKSYDLEPLPFLCDIFDREEKQ
FVEIGITRKADDSYFQSKFGKLGNSCKIFVFSYDGRLDKNCEGPMEEQKL
RIFSFLATAADFLRKENMFNEIFLPDNEETIIEMKKGKTFLELRDESVPL
PFQTYEQMKDYCEKFKGNPRELASKVSQMQSNIKLPIKHYEQNKFRQIRL
PKGPMAPYTHKFLMEEAWMFTKISDPERSRAGEILIDFFKKGNLSAIRPK
DKPLQGKYPIHYKNLWNQIKAAIADRTMVINENDHSEFLGGIGRASKKIP
EISLTQDVITTEGLKQSENKLPEPRSFPRWFNAEWMWAIKDSDLTGWVPM
AEYPPADNELEDYAEHLNKTMEGVLQGTNCAREMGKCILTVGALMTECRL
FPGKIKVVPIYARSKERKSMQEGLPVPSEMDCLFGICVKSKSHLNKDDGM
YTIITFEFSIREPNLEKHQKYTVFEAGHTTVREVPLYLYCRTTALSKIKN
DWLSKARRCFITTMDTVETICLRESAKAEENLVEKTLNEKQMWIGKKNGE
LIAQPLREALRVQLVQQFYFCIYNDSQLEGFCNEQKKILMALEGDKKNKS
SFGFNPEGLLEKIEECLINNPMCLFMAQRLNELVIEASKRGAKFFK
Ligand information
>6xzr Chain IN1 (length=19) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
aguagaaacaagggcccug
.<<....>>.<<<..>>>.
Receptor-Ligand Complex Structure
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PDB6xzr Host ANP32A mediates the assembly of the influenza virus replicase.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		G342 I343 R345 N370 P373 R450 H494 N496 M501 D636
Binding residue
(residue number reindexed from 1)		G341 I342 R344 N369 P372 R449 H493 N495 M500 D625
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6xzr, PDBe:6xzr, PDBj:6xzr
PDBsum6xzr
PubMed33208942
UniProtQ9IMP5|PA_INCJH Polymerase acidic protein (Gene Name=PA)

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