Structure of PDB 8ova Chain AP Binding Site BS01

Receptor Information
>8ova Chain AP (length=218) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EWVPCTKLGRLVKDQKITSLEEIFLFSMPIKEHQIVDQLIREGDLRDEMM
LVFPVQKATSAGQRTRFKAFNVVGDGNGHIGVGARVGKEVSLAIRASMIA
AKLSIVPVRRGYWGNKIGEPHTIPIKVTGKCGSVAVRLIPAPRGAGIVAA
PVPKKILEFAGVEDVYTSSCGKTRTRGNFIMATFYALRKTYGFLTPDLWA
ETEVSRDPTDEHSEFLSM
Ligand information
>8ova Chain AA (length=1919) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcauugcaggaaucugcgcauggcucauua
caucagacguaaucugccgccaaaauuuugcggcgcauuacuggauaacu
uggcgaaacgccaagcuaauacaugaaccaaucggacgcucucuuugaug
ggacguccagcgaaugaaugaaauuagaaccaacgccuccacccggaggc
aguaacacucagacguguugacucaauucauuccgugcgaaagccgagcu
gcucggcgucuacugacgaacaacugcccuaucagccagugauggccgug
uaguggacugccauggcguugacgggagcgggggauuaggguucgauucc
ggagagggagccugagaaauagcuaccacuucuacggagggcagcaggcg
cgcaaauugcccaaugucgaaaaaauacgaugaggcagcgaaaagaaaua
gagccgaccgugugguuguuuucaaugggggauacucaaacccauucaau
aucgaguaacaauuggaggacaagucuggugccagcacccgcgguaauuc
cagcuccaaaagcguauauuaaugcuguugcuguuaaaggguucguaguu
gaacugugggccacguaguguggugccguaccagucccguccaccucgac
guguuuugacccacgcccucguggccagauacaagaaacacgggagcagu
ucgcaugucaugcaugggggcguccgugaauuuacugugaccaaaaagau
gcgaccaaagcagucuugccgacuugaauuacaaagcaugggauaacgaa
gcaucagcccugggguuauguugguuuuagaaguccuugggagauuaugg
ggccgcguuguuucguguggcgcgccgcggcuuccaggaaugaaggaggg
uaguucgggggagaacguacuggugcgucagaggugaaauucuuagaccg
caccaagacgaacuacagcgaaggcauucuucaaggauaccuuccucaau
caagaaccaaaguguggggaucaaagaugauuagagaccauuguagucca
cacugcaaaccaugacacccaugaauuggggaacaucauuuuauuuauca
auuuacgugccuacucagcacguuucuuacuucuucacgcgaaagcuugg
agguuacagucucaggggggaguacguucgcaagagugaaacuuaaagaa
auugacggaauggcaccacaagacguggagcgugcgguuuaauuugacuc
aacacggggaacuuuaccagauccggacagggugaggauugacagaugga
guguucuuucucgauccccugaaugguggugcauggccgcuuuuggucgg
uggagugauuuguuugguugauuccgucaacggacgagauccaagcugcc
caguaggugccgggauuguccacacaggacagcaguccucgucauccuuc
uuuuuucaggccccuucucugcgggauuccuugcuuuucgcgcaagguga
gauuuugggcaacagcaggucugugaugcuccucaauguucugggcgaca
cgcgcacuacaaugucagugagaacaagagcgacgcucccgcuugaucaa
aagagcggggaaaccacggaaucacguagacccacuugggaccgaguauu
gcaauuauuggucgcgcaacgaggaaugucucguaggcgcagcucaucaa
acugugccgauuacgucccugccauuuguacacaccgcccgucguuguuu
ccgaugauggugcaauacaggugaucggaccgucaccgaaaguucaccga
uauugcuucaauagaggaagcaaaagucguaacaagguagcuguagguga
accugcagcuggaucauuu
...<<<<<...{{{{>>>>>{{{{.[[[[[[...[[[..........[[[
.[[[..<<....<<....<<<<...>>>>...>>.>>......{{.....
...[[[..[[..[[...[[..{......<<<<.>>>>....<<.....<<
<<<<.....>>>>>>......>>..........<<<<<.<<<<<<.>>.>
>>>>>>>>.[[((((((((.....<<<<<<<<<<<<<<<......>>>>>
.........................))))))))...]]....<<<<<<<.
>>>>>>>...}..]]..]]]]..]]].<<<....<<<....<<<<<.<<.
......>>.>>>>>>>>......>>>..<<<.<<<<....>>>>....>>
>.}}.<<.<<<..........>>>.>>.<<<<<..>>>>>...]]]]]].
........<<<....<<<..........>>>..>>>.......]]]....
<<<...<.<.....>.>...>>>.....<.<..............>....
..>.........<<<<<((....<.<<<<.....<<..))>>.......>
>>>>>>>>>..]]]]]]}}}}.........[[[[[.....((((...(((
.......<<<<...<...<..<<....<<..<.<...........>.>..
>>..>>.>...>..>>>>.................<...<<........<
...<<<.......>>>.>...>>...>...<<..<...........<...
<<.......>>..<......>.......>..........>....>>....
.......[[..(((.....>>>>>>>>>>....)))..]]........<<
<<<<<<<....<<<..>.>>.....>>>>>>>>>.............<<<
<<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>......>>
>>>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>....)))
...))))...<<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>
>>>>.........<<<.<<...<..<.<<<<<..................
......<<<<.......>>>>.>>>>>.>..>......<<..]]>>....
.>>.....>>>.]]].<<<......<<<<....>>>>....>>>..}}}}
..<<<<<.<<<<<<<..<<.<<<<<<..<<.<<<<<<<......<<....
....>>..........<<<<<.<....<<<<<........<<.<<<....
....>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<
<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.<<<<.
....<<<.<<<<<<................................>>>.
........>>>.>>>.....>>>>....<<<<<<<....>.>>>>>>...
....>>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...>>.
>>>>>.>>.....<<<.<<<.......<...<....><<<<<<<......
..>>>>>>>....>........>>>...>>>......<....<<<.<<..
........>>.>>>.....>.....>>>>>>....<<<<<<<........
.>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<.<<<<<<
<<..<<.<<<.<<<<<<..<<<<<.<...<.<<.>>.>...>.>>>>>..
>>>>>>.>>>.>>..>>>>>>>>..>.>>...>.....<<<<<<<<<...
.>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ova A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.47 Å
Binding residue
(original residue number in PDB)		Q97 K98 A99 T100 A102 R107 K109 T169 K171 S174 R178 V189 A190 A191 Y207 T208 S210 K213 R215 T216 N219 F234
Binding residue
(residue number reindexed from 1)		Q56 K57 A58 T59 A61 R66 K68 T128 K130 S133 R137 V148 A149 A150 Y166 T167 S169 K172 R174 T175 N178 F193
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ova, PDBe:8ova, PDBj:8ova
PDBsum8ova
PubMed37985661
UniProtQ388D3

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