Structure of PDB 8c3a Chain AN Binding Site BS01

Receptor Information
>8c3a Chain AN (length=52) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIEPSLKALASKYNCEKSICRKCYARLPPRATNCRKRKCGHTNQLRPKKK
LK
Ligand information
>8c3a Chain 1 (length=3217) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggag
gaauguggcacggcuucugcuguguguuauagccucugacgauacugcca
gccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucu
uaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgag
uguuuggguguaaaacccguacgcguaaugaaagugaacgaagguggggg
cccauuagggugcaccaucgaccgauccugauguguucggauggauuuga
guaagagcauagcuguugggacccgaaagauggugaacuaugccugaaua
gggugaagccagaggaaacucugguggaggcucguagcgguucugacgug
caaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccau
cuaguagcugguuccugccgaaguuucccucaggauagcagaagcucgua
ucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaauga
ccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaa
uugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaa
gcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaa
ugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccgg
acgguggccauggaagucggaauccgcuaaggaguguguaacaacucacc
ggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuua
uacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcgugg
aggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagu
gcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacug
aaguggggaaagguuccaugucaacagcaguuggacauggguuagucgau
ccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaa
ccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuu
cacggcaacguaacugaauguggagacgucggcgugagcccugggaggag
uuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggag
auggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcg
cuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaag
ucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugau
agaauaauguagauaagggaagucggcaaaauagauccguaacuucggga
uaaggauuggcucuaaggaucgguuuaacgaucaacuuagaacugguacg
gacaaggggaaucugacugucuaauuaaaacauagcauugugauggucag
aaagugauguugacacaaugugauuucugcccagugcucugaaugucaaa
gugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacuc
ucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaug
gauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagc
caagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagc
uugacucuaguuugacauugugaaaagacauggaggguguagaauaagug
ggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuua
uucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagccc
ucugggcgauccggguugaagacauugucagguggggaguuuggcugggg
cggcacaucuguuaaacgauaacgcagguguccuaagggggacucaugga
gaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuuga
uuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagu
cccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaac
uggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucg
augucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauu
guucacccacuaauagggaacgugagcuggguuuagaccgucgugagaca
gguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuua
guacgagaggaaccguucauucagauaauugguuuuugcggcugucugau
caggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucu
aagucagaauccaugcuagaacgcgaugauuuugcccugcacauuuuaga
uggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacg
gugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaauguca
acaugcgcggggauaaauccuuugcauacgacuuagauguacaacggagu
auuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcu
cuuguugucugauuugu
.......................<<<<<<.....<......>......>>
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>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.........
....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>
>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]....}..........................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<..<<<<.
.>>>>..>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<
<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.
>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>
>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<
<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<
<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.
>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..
<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<....
....>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>
>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...
<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>
>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<....
..>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<....
.>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((....
.<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<
.<<<...<<.........>>...>>>.........<<......>>...>>
>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>.
.>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<
<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..
......>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.
....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<
<<...<<....<<<....>>>..........<<<<<<....>>>>>>...
...>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<....
.<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<
..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>...
.>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>
>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>
>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<
<<<.....<<<<<<<.<<...............<<<<<............
...>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>......
......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.
....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....
.<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>
>>........<...........<<<<<.......>>>>>.....>.....
>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<
<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[
[..<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<..............
..............................>>.>...>>>>>>>>>>...
<<<<<.....<<<<..<<<<<......>>>>>..............<<<<
...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<....
.>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<
<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<
<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((.
.((((.>>>>>>))))))))))..........]]]]..}}]]]]......
.<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>....
...<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<...
......>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.
>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<...
..............>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}
.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<..........
.>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<....
.<<..........<<<......>>>......>>.......<<<<<<...<
<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............
>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.
<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>
>>.>>>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8c3a New crystal system to promote screening for new eukaryotic inhibitors
Resolution3.0 Å
Binding residue
(original residue number in PDB)
R21 Y24 R26 P28 R30 T32 N33 R35 K36 R37 K38 G40 H41 N43 R46 K48 K49 L51
Binding residue
(residue number reindexed from 1)
R21 Y24 R26 P28 R30 T32 N33 R35 K36 R37 K38 G40 H41 N43 R46 K48 K49 L51
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8c3a, PDBe:8c3a, PDBj:8c3a
PDBsum8c3a
PubMed
UniProtA0A1D8PL68|RL40B_CANAL Large ribosomal subunit protein eL40 (Gene Name=RPL40B)

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