Structure of PDB 4v6i Chain AN Binding Site BS01

Receptor Information

>4v6i Chain AN (length=48) Species: 4932 (Saccharomyces cerevisiae)

SHPRRYGKGSRQCRVCSSHTGLIRKYGLNICRQCFREKANDIGFNKFR

Ligand information

>4v6i Chain CA (length=1721)

uaucugguugauccugccaguagucauaugcuugucucaaaguuaagcca
ugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucau
uaaaucaguuaucguuuauuugauagacauggauaacugugguaauucua
gagcuaauacauguuaaaaucucgacccuuuggaagagauguauuuauua
gauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuuc
gaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuau
caacuuuaugguaggauaguggccuaccaugguuucaacggguaacgggg
aauaaggguucgauuccggagagggagccugagaaacggcuaccacaucc
aaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguag
ugacaauaaauaacgauacagggcccauucgggucuuguaauuggaauga
guacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugc
cagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugca
guuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuu
uucguguacuggauuuccaacgggguccuucuggcuaaccuugaguccuu
guggcucuuggcgaaccaguguucaaagcaggcguauugcucgaauauac
guuugguucuauuuuguugguuucuaggaccaucguaauggggacggucg
ggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaag
acuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaac
gaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccaua
aacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggc
accuuagagaaaucaaagucuuuggguucuggggggaguauggucgcaag
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacggggaaacucaccagguccagacacaaua
aggauugacagauugagagcucuuucuugauuuugugggugguggugcau
ggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaa
cgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccac
uucuuagagggacuaucgguuucaagccgauggaaguugaggcaauaaca
ggucugugaugcccuuaacguucugggcgcacgcgcgcuacacugacgga
gccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuc
cgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauu
ccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuug
uacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucag
gaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggac
aaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggu
gaaccugcggaaggaucauua

...<<<<<.[.((((>>>>><<<<..<<<<<...<...........<<<.
<<<...<...<<.....<............>....>>>.......<<...
.....<<<..<<..<<...........<<<<.....<<.<<<.....>>>
.>>......>>>>.<.<<<.........>>>.>....<.<<<<[......
((...((..<..<.....>..>.............>.]..>>>.>.....
<..<<<<.<<<<.....>>>>>>>>>.........>>>>..>>>.<<<..
..<<<..<<<<<<<.........>>>>>>>>>>......>>>...<<<<<
<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<.
...>>.>...>>>>>>.......<.<<<...<<<<.....>>>.>>>>>.
.......>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......
..............................<<<<<((......<<<<...
..<<..))>>.......>>>>.>>>>>..>>>>>.>>>>.........<<
<[[.....<.<<...<<<..............<..<.....<..<..<..
...>..>...>..>...>.......<...<.<<.<.<...<<..<....>
..>>...>.>.>>.>...>.<<.....<..<......>..>.....>>.<
...<<<<<<<<.....))...)).>>>>>>>>..>......<<<<<.<<.
..<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.
>>>......<<<....>>>..>>>>..>>.>>>.>>....>>>...>>.>
....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>....
......<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>.
.>>>..<<.].]>>...>>.....>>>.>>>.<<<......<<<......
>>>....>>>..)))).]<<<<<.<<<<<<<...<..<<<<<..<<<.<<
<<<<......<..........>..........<<<<<........<<..<
<<....<<............>>........>>>..>>...<..<<<..<<
.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>
>......<<..<<<.<<<<..<<<<..<<<<<......>>>>>....>>>
>..>>>>>>>.....<<<<.......>>>>........>>......>>>.
>>>.....>>>>>.>......>>>>>..>>.>>>>.>>>.....<<<<<.
........<..........<<<....>>>..........>.........>
>>>>...........<<<<<<..........>>>>>>..........>>>
>>.....<<<<<<<<<.....>>>>>>>>>......>....>>>>>>>>>
>.>>.......<<.<..<<...<<....<<<<<<<<.<<<..<.<<....
..<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>......>>.>
..>>>.>>>>>>>>...>>...>>...>.>>.........<<<<<<<<<.
...>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v6i Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
• Resolution: 8.8 Å
• Binding residue (original residue number in PDB): S9 H10 R12 Y14 C24 S25 G29 L30 R32 N37 I38 C39
• Binding residue (residue number reindexed from 1): S1 H2 R4 Y6 C16 S17 G21 L22 R24 N29 I30 C31

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v6i, PDBe:4v6i, PDBj:4v6i
• PDBsum: 4v6i
• PubMed: 20980660
• UniProt: P41057|RS29A_YEAST Small ribosomal subunit protein uS14A (Gene Name=RPS29A)