Structure of PDB 4v4w Chain AN Binding Site BS01

Receptor Information

>4v4w Chain AN (length=61) Species: 562 (Escherichia coli)

RWNAVLKLQTLPRDSSPSRQRNRCRQTGRPHGFLRKFGLSRIKVREAAMR
GEIPGLKKASW

Ligand information

>4v4w Chain AA (length=1488)

ugaagaguuugaucauggcucagauugaacgcuggcggcaggccuaacac
augcaagucgaacgguccggaagaagcuuucuuuuggacaguggcggacg
ggugaguaaugucugggaaacugccugauggagggggauaacuacuggaa
acgguagcuaauaccgcauaacgucgcaagaccaaagagguuuucuugcc
aucggaugugcccagaugggauuagcuaguaggugggguaacggcucacc
uaggcgacgaucccuagcuggucugagaggaugaccagccacacuggaac
ugagacacgguccagacuccuacgggaggcagcaguggggaauauugcac
aaugggcgcaagccugaugcagccaugccgcguguaugaagaaggccuuc
ggguuguaaaguacuuucgcggggaggaagggagcgacgagcucauugac
guuacccgcgaaguagcaccggcuaacuccgugccagcagccgcgguaau
acggagggugcaagcguuaaucggaauuacugggcguaaagcgcacgcag
gcgguuuguuaagucagaugugaaauccccgggcucaaccugggaacugc
aucugauacuggcaagcuugagucucguagagggggguagaauuccaggu
guagcggugaaaugcguagagaucuggaggaauaccgguggcgaaggcgg
cccccuggacgaagacugacgcucaggugcgaaagcguggggagcaaaca
ggauuagauacccugguaguccacgccguaaacgaugucgacuuggaggu
ugugucucguggcuuccggagcuaacgcguuaagucgaccgccuggggag
uacggccgcaagguuaaaacucaaaugaauugacgggggcccgcacaagc
gguggagcaugugguuuaauucgaugcaacgcgaagaaccuuaccugguc
uugacauccacggaaguuuucagagaugagaaugugccuucgggaaccgu
gagacaggugcugcauggcugucgucagcucguguugugaaauguugggu
uaagucccgcaacgagcgcaacccuuauccuuuguugccagcgguccggc
cgggaacucaaaggagacugccagugauaacuggaggaagguggggauga
cgucaagucaucauggcccuuacgaccagggcuacacacgugcuacaaug
gcgacuacaaagagaagcgaccucgcgagagcaagcggaccucauaaagu
gcgucguaguccggauuggagucugcaacucgacuccaugaagucggaau
cgcuaguaaucguggaucagaaugccacggugaauacguucccgggccuu
guacacaccgcccgucacaccaugggaguggguugcaaaagaaguaggua
gcaaccuucggggcgcuuaccacuuugugauucaugacuggggugaaguc
guaacaagguaaccguaggggaaccugcgguuggauca

....<<<<....((((.>>>>.<<<<..<......<<<<<<<.....<<<
.<<<..<<<..<<.<<<<<<<<<<.....>>>>>>>>>>.>>>>>.....
.<<.......<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<....
..>>>>>......>>.>.....<<<....>>>....<<<<...>>>>.>>
>>>>>..>>.>>>>>>><<<....<<<..<<<<<<<.........>>>>>
>>>>>......>>>..<<<<<<<<....>>>...>>>>>.>>.<<<<<.<
.........>>>>>>.<<<<....>>>>...>>>>>>.........<<<.
..<<<<<....>>>>.>>>>..>>.>>>>>...<<<<......<<<<<..
>>>>>.....>>>>..<<<<<<<.......<<<<<.....>>>>.>....
....>>>>>>>....<<<<<(((...<<<<<.....<<.)))>>......
.>>>>>>>>>>......>>>>>..........<<<((.....<<<<...<
<<.<<<<<<<.<<<<<<<<<<......<<<<<<.....>>>>>>....>>
>>>>>>..>>>>>>>>>...<<<<<<<<...<<<<<<<....<<<<<<<<
.<.<<<......>>>.....>>>>>>>>>...........<<....>>.>
>>>>>>..>>>>.>>>>...>>>...>>>>....<<<<<<...<<...<<
<<.<.....>.>>>>...>>>>>>>>..........<<<<<<.<<<<<<<
<<<<...>>>>>>>>>>>..<<..))>>.....>>>>>>.>>>..<<...
...<<<<....>>>>....>>...))))..<<<<<.<<<<<<<.....<<
<<<..<<<<<<<<<<......<<........>>..........<<<<<<<
......<<.......<<<<<<<....>>>>>>>...<......>......
..>>.<<<.<<<..<<<<<<.......<<<<<<<<<....>>>..<<<<.
.....>>>>..>>>>>>.....<<<..<<<<<<<...<...<<<.....>
>>.>....>>>>>>>.....<<<<<....>>>>>.........>>>....
.....>>>...>>>>>>>>>...>>>>>>>...>>.>>>>>>>>......
<<<........<<<..<....<<<....>>>....>....>>>.......
.>>>............<<<<<<<........>>>>>>>..........>>
>>>.....<<<<<<<.........>>>>>>>...........>>>>>>>>
>>.>>.......<<.<.<<<<.<<<..<<<<<<<<<<<<....<<<<<<.
....<<....>>..>>>>>>...>>>>>>>>>>>>..>>>.>>>>..>.>
>.........<<<<<<<<<....>>>>>>>>>......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v4w Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements
• Resolution: 15.0 Å
• Binding residue (original residue number in PDB): L47 R64 W100
• Binding residue (residue number reindexed from 1): L8 R25 W61

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:4v4w, PDBe:4v4w, PDBj:4v4w
• PDBsum: 4v4w
• PubMed: 16713583
• UniProt: P0AG59|RS14_ECOLI Small ribosomal subunit protein uS14 (Gene Name=rpsN)