Structure of PDB 7tor Chain AL42 Binding Site BS01 |
|
|
| >7tor Chain A28S (length=3552)
[Search RNA sequence]
[Download ligand structure]
[Download structure with residue number starting from 1]
[View ligand structure]
|
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaau
guggcguacggaagacccacuccccggcgcgggggcccaaguccuucuga
ucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcg
ccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaag
cgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauaguc
aacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaa
gagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgc
ccggaggauucaacccggcggcgcgguccggccgugccggcggggcggau
ccccgcucucggcgggggaccgccccccggccggcgaccggccgccgccg
ggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugg
gaaggccccggcggggaagguggcccgggggccccggguguuacagcccc
gccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccc
gugcgccgcgcucuccccccggggggccgggccaccccucccacggcgcg
accgcuggggcggacuguccagugcgccccgggcgggucgcgccgucggg
cccggggggccacgcguccagcgcacggggucggcggcgaugucggcuac
ccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcga
gucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggccg
gccgaggugggaucccgaggcaguccgccgagggcgcaccaccggcccgu
cucgcccgccgcgccggggagguggagcacgagcgcacguguuaggaccc
gaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugg
uggagguccguagcgguccugacgugcgaaucggucguccgaccugggua
uaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaagu
uucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaau
gauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaa
auggguaagaagcccggcucgcugguguggagccgggcguggaaugcgag
ugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaacc
gaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaa
gguguugguugauauagacagcaggaugguggccauggaagucggaaucc
gcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaau
ggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggc
agagcgagaaagagagggacgcuacgccgcgacgaguaggagggccgcug
cggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggu
gcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccg
aaguggagaaggguuccaugugaacagcaguugaacaugggucagucggu
ccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccgu
ugcccucagccgaucgaaagggagucggguucagauccccgaauccggag
uggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucc
cggagaagccggcgggagccccggggagaguucucuuuucuuugugaagg
gcagggcgcccuggaauggguucgccccgagagaggggcccgugccuugg
aaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaa
aauccgggggagaggguguaaaucucgcgccgggccguacccauauccgc
agcaggucuccaaggugaacagccucuggcauguuggaacaauguaggua
agggaagucggcaagccggauccguaacuucgggauaaggauuggcucua
agggcucagccgacuuagaacuggugcggaccaggggaauccgacuguuu
aauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugug
auuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgc
ggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccuc
gucaucuaauuagugacgcgcaugaauggaugaacgagauucccacuguc
ccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaa
ucagcggggaaagaagacccuguugagcuugacucuagucuggcacggug
aagagacaugagagguguagaauaagugggaggccggccgccggugaaau
accacuacucugaucguuuuuucacugacccggugaggcgggggggcgag
ggcucucgcuucuggcgccaagcgcccggcgccgggcgcgacccgcuccg
gggacagugccagguggggaguuugacuggggcgguacaccugucaaacg
guaacgcagguguccuaaggcgagcucagggaggacagaaaccucccgug
gagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacag
accgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagca
ggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaag
cguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuauc
auugugaagcagaauucaccaagcguuggauuguucacccacuaauaggg
aacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacu
gaugauguguuguugccaugguaauccugcucaguacgagaggaaccgca
gguucagacauuugguguaugugcuuggcugaggagccaauggggcgaag
cuaccaucugugggauuaugacugaacgccucuaagucagaaucccgccc
aggcggaacgauagccggagccucgguuggccucggauagccgguccccc
ggggguccggugcggagagcccuucgucccgggaaacggggcggccggaa
agggggccgcccucucgcccgucacgcaccgcacguucguggggaaccug
gcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacgu
agcagagcaggcugcgaucuauugaaagucagcccucgacacaaggguuu
gu |
.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<<.....<<.....>>....
>>>>>>..<<<...<<<<...<<<<<<<<<<.....>>>>>>.>>>>...
..>>>>...<<<<<<<<<....<<<<<<<<<<<<<<<<....<<<<....
..>>>>.....((......<<<.....))>>>...>.>>>>>>>...>>>
>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>....
.<<<<<..((((((>>>>>..>>>..........................
........<<....>>...............<<<<....>>>>.......
...........................<<<<<<<<..<<<.<....<<<<
<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<<<<<<<.<
<<<<<<.....>>>>>.>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>
>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...
<<..<<<..<<<<<<<......<<<<<<<...>>>>>>>.......>>>>
>>>..>>>.........>>>>>>..>>>>>>>>>>>.....<<.......
>>.........<...<<<<<.>>>>>....<<<...<<.<<<<<<<<<<<
<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>>>.>>>>>>>>>>>.>>>
...>>..>>>..........>.........>>.>>>>>....>>>>...>
>>>>>>>..<<<<........>>>><<<<<<....<<<<<<<<<<<<<..
<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<..>>
>>>..<<<<<...<<<..<<...[[..>>..>>>....>>>>>.<<<<<<
<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.
<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>
>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>
>...<<.......>>......>>>>>>......>.>>..<<<<<<....<
.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<<...<<<....<
<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>..
.>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>
>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>
>...<<<<<<<...<<<(((.......<<<<<.....<<..........<
<<.<<<<<<<<<<.......<<<<<.<<<...................>>
>......................>>>>>...>>>>>>>>>>>>>......
....))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......
.............]]..........>>>>>>>>>....>>>>>>...<<<
<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..
......>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.
....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<
<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>
>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<..
..<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<
<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<
<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>..
...<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.......
..>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<..
....>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<
.<<...............<<<<<....<<..>>.....>>>>><<.<<<<
<<<<<<.>>>>..>>>>>>.>>............<<<<<<<<<..<<<..
.......>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.
..<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.
>>>>..>>>>><<<<<<.......>>>>>>........<...........
<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>
>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<
<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<
<<<<<<<<<.<<<<...........<<<<..<<<..>>>...........
.>>>>..>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<.
...>>>>..............<<<<<<<<..>>>>>>>>..>>>>..>>>
>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<......
.....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>...
..<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>
><<<<....>>>>>>)))......<<<<<<<..<<<..)))))).>>>>>
>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<
<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<
.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>
>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>
>>>.....<<<<<<.<..<<<..<.<<<<<.................>>>
>>.><<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>
>>>...>>>><<<<<...<<<<<...........>>>>>...>>>>>.>>
>...>.>>>>>>.<<<<<..<<<<....<<<........<<<<<..<<<<
.>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<....
....>>>>>>.>>>...>>>>..>>>..............>>>>..>.>>
>>...<<<<<.<.............>....<<.<<<<<<<.<<.....<<
<<....<<<<.>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>
.. |
|
| Global view | Local view | Structure summary |
[Spin on]
[Spin off]
[Reset]
[High quality]
[Low quality]
[White background]
[Black background]
|
[Spin on]
[Spin off]
[Reset]
[High quality]
[Low quality]
[White background]
[Black background]
|
| PDB | 7tor Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM. |
| Resolution | 2.9 Å |
Binding residue
(original residue number in PDB) | V2 N3 P5 R8 R9 T10 F11 K13 K17 H18 Y26 K28 D31 S32 Y34 A35 Q36 G37 R39 R40 R43 K44 G47 Y48 G50 Q51 T52 P54 I55 F56 K58 K59 A60 K61 T63 K64 K65 K80 R81 K86 C88 K89 K97 K98 K100 |
Binding residue
(residue number reindexed from 1) | V1 N2 P4 R7 R8 T9 F10 K12 K16 H17 Y25 K27 D30 S31 Y33 A34 Q35 G36 R38 R39 R42 K43 G46 Y47 G49 Q50 T51 P53 I54 F55 K57 K58 A59 K60 T62 K63 K64 K79 R80 K85 C87 K88 K96 K97 K99 |
|
|
| Enzyme Commision number |
? |
|
|
|
|
|
