Structure of PDB 7tor Chain AL39 Binding Site BS01

Receptor Information
>7tor Chain AL39 (length=50) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSHKTFRIKRFLAKKQKQNRPIPQWIWMKTGNKIRYNSKRRHWRRTKLGL
Ligand information
>7tor Chain A28S (length=3552) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggaaau
guggcguacggaagacccacuccccggcgcgggggcccaaguccuucuga
ucgaggcccagcccguggacggugugaggccgguagcggcccccggcgcg
ccgggcccgggucuucccggagucggguugcuugggaaugcagcccaaag
cgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauaguc
aacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaa
gagggcgugaaaccguuaagagguaaacgggugggguccgcgcaguccgc
ccggaggauucaacccggcggcgcgguccggccgugccggcggggcggau
ccccgcucucggcgggggaccgccccccggccggcgaccggccgccgccg
ggcgcauuuccaccgcggcggugcgccgcgaccggcuccgggacggcugg
gaaggccccggcggggaagguggcccgggggccccggguguuacagcccc
gccccggcagcagcagcucgccgaaucccggggccgagggagcgagaccc
gugcgccgcgcucuccccccggggggccgggccaccccucccacggcgcg
accgcuggggcggacuguccagugcgccccgggcgggucgcgccgucggg
cccggggggccacgcguccagcgcacggggucggcggcgaugucggcuac
ccacccgacccgucuugaaacacggaccaaggagucuaacacgugcgcga
gucgggggcuacgaaagccgccguggcgcaaugaaggugaaggccggccg
gccgaggugggaucccgaggcaguccgccgagggcgcaccaccggcccgu
cucgcccgccgcgccggggagguggagcacgagcgcacguguuaggaccc
gaaagauggugaacuaugccugggcagggcgaagccagaggaaacucugg
uggagguccguagcgguccugacgugcgaaucggucguccgaccugggua
uaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccaaagu
uucccucaggauagcuggcgcucuccgcaguuuuauccgguaaagcgaau
gauuagaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaa
auggguaagaagcccggcucgcugguguggagccgggcguggaaugcgag
ugccuagugggccacuuuugguaagcagaacuggcgcugcgggaugaacc
gaacgccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaa
gguguugguugauauagacagcaggaugguggccauggaagucggaaucc
gcuaaggaguguguaacaacucaccugccgaaucaacuagcccugaaaau
ggauggcgcuggagcgucgggcccauacccggccgucgcuggcagucggc
agagcgagaaagagagggacgcuacgccgcgacgaguaggagggccgcug
cggugagccuugaagccuagggcgcgggcccggguggagccgccgcaggu
gcagaucuuggugguaguagcaaauauucaaacgagaacuuugaaggccg
aaguggagaaggguuccaugugaacagcaguugaacaugggucagucggu
ccugagagaugggcgagcgccguuccgaagggacgggcgauggccuccgu
ugcccucagccgaucgaaagggagucggguucagauccccgaauccggag
uggcggagaugggcgccgcgaggcguccagugcgguaacgcgaccgaucc
cggagaagccggcgggagccccggggagaguucucuuuucuuugugaagg
gcagggcgcccuggaauggguucgccccgagagaggggcccgugccuugg
aaagcgucgcgguuccggcggcguccggugagcucucgcuggcccuugaa
aauccgggggagaggguguaaaucucgcgccgggccguacccauauccgc
agcaggucuccaaggugaacagccucuggcauguuggaacaauguaggua
agggaagucggcaagccggauccguaacuucgggauaaggauuggcucua
agggcucagccgacuuagaacuggugcggaccaggggaauccgacuguuu
aauuaaaacaaagcaucgcgaaggcccgcggcggguguugacgcgaugug
auuucugcccagugcucugaaugucaaagugaagaaauucaaugaagcgc
ggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccuc
gucaucuaauuagugacgcgcaugaauggaugaacgagauucccacuguc
ccuaccuacuauccagcgaaaccacagccaagggaacgggcuuggcggaa
ucagcggggaaagaagacccuguugagcuugacucuagucuggcacggug
aagagacaugagagguguagaauaagugggaggccggccgccggugaaau
accacuacucugaucguuuuuucacugacccggugaggcgggggggcgag
ggcucucgcuucuggcgccaagcgcccggcgccgggcgcgacccgcuccg
gggacagugccagguggggaguuugacuggggcgguacaccugucaaacg
guaacgcagguguccuaaggcgagcucagggaggacagaaaccucccgug
gagcagaagggcaaaagcucgcuugaucuugauuuucaguacgaauacag
accgugaaagcggggccucacgauccuucugaccuuuuggguuuuaagca
ggaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaag
cguucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuauc
auugugaagcagaauucaccaagcguuggauuguucacccacuaauaggg
aacgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacu
gaugauguguuguugccaugguaauccugcucaguacgagaggaaccgca
gguucagacauuugguguaugugcuuggcugaggagccaauggggcgaag
cuaccaucugugggauuaugacugaacgccucuaagucagaaucccgccc
aggcggaacgauagccggagccucgguuggccucggauagccgguccccc
ggggguccggugcggagagcccuucgucccgggaaacggggcggccggaa
agggggccgcccucucgcccgucacgcaccgcacguucguggggaaccug
gcgcuaaaccauucguagacgaccugcuucugggucgggguuucguacgu
agcagagcaggcugcgaucuauugaaagucagcccucgacacaaggguuu
gu
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>>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>....
.<<<<<..((((((>>>>>..>>>..........................
........<<....>>...............<<<<....>>>>.......
...........................<<<<<<<<..<<<.<....<<<<
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<<<<<<.....>>>>>.>>>>>>>>>>>>>>>>>>...>>>.>>>>>>>>
>>......>>>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<<<...
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<<<...<<<<.....>>>>.....>>>...<<....>>...<<<<<..>>
>>>..<<<<<...<<<..<<...[[..>>..>>>....>>>>>.<<<<<<
<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.
<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>
>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>
>...<<.......>>......>>>>>>......>.>>..<<<<<<....<
.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<<<...<<<....<
<<..<.<<<..<<<<.<.........>.>>>>>>>.>..>>>..>.>>..
.>>>>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>
>>>>.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>
>...<<<<<<<...<<<(((.......<<<<<.....<<..........<
<<.<<<<<<<<<<.......<<<<<.<<<...................>>
>......................>>>>>...>>>>>>>>>>>>>......
....))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<.......
.............]]..........>>>>>>>>>....>>>>>>...<<<
<<<<<.<<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..
......>>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.
....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<
<<...<<....<<<....>>>..........<<.<<<<<<<<<...>>>>
>>>>>>>......>>....>>>..<<<<<........>>>>>))<<<<..
..<<<<<..<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<
<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>....<<<
<<.<<<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>..
...<<<<<<<.......>>>>>>>>>>>...>>>>>>>>>>>>.......
..>>>>>>>..>..........>>.>>>.>>>>.>>>..>>.....<<..
....>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<
.<<...............<<<<<....<<..>>.....>>>>><<.<<<<
<<<<<<.>>>>..>>>>>>.>>............<<<<<<<<<..<<<..
.......>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>.
..<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>.
>>>>..>>>>><<<<<<.......>>>>>>........<...........
<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>.....>
>.>>>>>>>..>>>>>>....>>....<<<<<........>>>>>....<
<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<<.<<<
<<<<<<<<<.<<<<...........<<<<..<<<..>>>...........
.>>>>..>>>>.>>.>>>>>>>>>>...<<<<<.....<<<<..<<.<<.
...>>>>..............<<<<<<<<..>>>>>>>>..>>>>..>>>
>>....>>>>>>>>>..>>>>>...<<<.....>>>..<<<<<<......
.....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>...
..<<...(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>
><<<<....>>>>>>)))......<<<<<<<..<<<..)))))).>>>>>
>>>>>.........>>>>..>>>>>>.......<<.<.<.<<<<<<...<
<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<..<
.<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>
>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>.>>
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>...>.>>>>>>.<<<<<..<<<<....<<<........<<<<<..<<<<
.>>>>.>>>>>.......>>>...<<<..<<<<....<<<<<<<<<....
....>>>>>>.>>>...>>>>..>>>..............>>>>..>.>>
>>...<<<<<.<.............>....<<.<<<<<<<.<<.....<<
<<....<<<<.>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>
..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7tor Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Resolution2.9 Å
Binding residue
(original residue number in PDB)
S2 S3 H4 K5 K10 L13 Q17 I35 R36 Y37 S39 R41 R42 H43 W44 R45 T47 K48 L51
Binding residue
(residue number reindexed from 1)
S1 S2 H3 K4 K9 L12 Q16 I34 R35 Y36 S38 R40 R41 H42 W43 R44 T46 K47 L50
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7tor, PDBe:7tor, PDBj:7tor
PDBsum7tor
PubMed35589706
UniProtG1TTN1

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