Structure of PDB 7toq Chain AL12 Binding Site BS01

Receptor Information
>7toq Chain AL12 (length=38) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSASALIIKAFDEIVNIARQMRHLSGTIKEILGTAQSV
Ligand information
>7toq Chain A25S (length=3649) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggagaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggcggggcgcgggacau
guggcguacggaagacccgcuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcccgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcgcgguccggccgugucggcg
gcccggcggaucucccgcucccgucggcgggggaccgucccccgaccggc
gaccggccgccgccgggcgcauuuccaccgcggcggugcgccgcgaccgg
cuccgggacggcugggaaggccccggcggggaagguggcccgggggcccc
ggguguuacagccccgccccggcagcagcagcucgccgaaucccggggcc
gagggagcgagacccgugcgccgcgcucuccccccucgggggggccgggc
caccccucccacggcgcgaccgcuggggcggacuguccagugcgccccgg
gcgggucgcgccgucgggcccggggggccacgcgucccccgcgagcgcac
ggggucggcggcgaugucggcuacccacccgacccgucuugaaacacgga
ccaaggagucuaacacgugcgcgagucgggggcucgcacgaaagccgccg
uggcgcaaugaaggugaaggccggcgcgcucgccggccgaggugggaucc
cgaggcaguccgccgagggcgcaccaccggcccgucucgcccgccgcgcc
ggggagguggagcacgagcgcacguguuaggacccgaaagauggugaacu
augccugggcagggcgaagccagaggaaacucugguggagguccguagcg
guccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacu
aaucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagc
uggcgcucuccgcaguuuuauccgguaaagcgaaugauuagaggucuugg
ggccgaaacgaucucaaccuauucucaaacuuuaaauggguaagaagccc
ggcucgcugguguggagccgggcguggaaugcgagugccuagugggccac
uuuugguaagcagaacuggcgcugcgggaugaaccgaacgccggguuaag
gcgcccgaugccgacgcucaucagaccccagaaaagguguugguugauau
agacagcaggaugguggccauggaagucggaauccgcuaaggagugugua
acaacucaccugccgaaucaacuagcccugaaaauggauggcgcuggagc
gucgggcccauacccggccgucgccggcagucggcagagcgagaaagaga
guggcgcggacgcuacgccgcgacgaguaggagggccgcugcggugagcc
uugaagccuagggcgcgggcccggguggagccgccgcaggugcagaucuu
ggugguaguagcaaauauucaaacgagaacuuugaaggccgaaguggaga
aggguuccaugugaacagcaguugaacaugggucagucgguccugagaga
ugggcgagcgccguuccgaagggacgggcgauggccuccguugcccucgg
ccgaucgaaagggagucggguucagauccccgaauccggaguggcggaga
ugggcgccgcgaggcguccagugcgguaacgcgaccgaucccggagaagc
cggcgggagccccggggagaguucucuuuucuuugugaagggcagggcgc
ccuggaauggguucgccccgagagaggggcccgugccuuggaaagcgucg
cgguuccggcggcguccggugagcucucgcuggcccuugaaaauccgggg
gagaggguguaaaucucgcgccgggccguacccauauccgcagcaggucu
ccaaggugaacagccucuggcauguuggaacaauguagguaagggaaguc
ggcaagccggauccguaacuucgggauaaggauuggcucuaagggcuggg
ucggucgcggccggcgccuagcagccgacuuagaacuggugcggaccagg
ggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgcggcggg
uguugacgcgaugugauuucugcccagugcucugaaugucaaagugaaga
aauucaaugaagcgcggguaaacggcgggaguaacuaugacucucuuaag
guagccaaaugccucgucaucuaauuagugacgcgcaugaauggaugaac
gagauucccacugucccuaccuacuauccagcgaaaccacagccaaggga
acgggcuuggcggaaucagcggggaaagaagacccuguugagcuugacuc
uagucuggcacggugaagagacaugagagguguagaauaagugggaggcc
ggccgccggugaaauaccacuacucugaucguuuuuucacugacccggug
aggcgggggggcgagccccgaggggcucucgcuucuggcgccaagcgccc
ggccgcgcgccggccgggcgcgacccgcuccggggacagugccagguggg
gaguuugacuggggcgguacaccugucaaacgguaacgcagguguccuaa
ggcgagcucagggaggacagaaaccucccguggagcagaagggcaaaagc
ucgcuugaucuugauuuucaguacgaauacagaccgugaaagcggggccu
cacgauccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguu
accacagggauaacuggcuuguggcggccaagcguucauagcgacgucgc
uuuuugauccuucgaugucggcucuuccuaucauugugaagcagaauuca
ccaagcguuggauuguucacccacuaauagggaacgugagcuggguuuag
accgucgugagacagguuaguuuuacccuacugaugauguguuguugcca
ugguaauccugcucaguacgagaggaaccgcagguucagacauuuggugu
augugcuuggcugaggagccaauggggcgaagcuaccaucugugggauua
ugacugaacgccucuaagucagaaucccgcccaggcggaacgauacggca
gcgccggagccucgguuggccucggauagccggucccccgcgggguccgg
ugcggagagcccuucgucccgggaaacggggcggccggaaagggggccgc
ccucucgcccgucacgcaccgcacguucguggggaaccuggcgcuaaacc
auucguagacgaccugcuucugggucgggguuucguacguagcagagcag
cucccucgcugcgaucuauugaaagucagcccucgacacaaggguuugu
.........................<<<<<<<....<......>.....>
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..>>>>...<<<<<<<<<....<<<<<<<<.<......<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>
>>>>.....(((((..<<<<<<)))))..]]]..................
................<<....>>...............<<<......>>
>..................................<<<<<<<<..<<<.<
<...<<<<<<<<.<<<.....<<<<<<<<<<....<<<<<<<.<<<<<.<
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...>>>.>>>>>>>>>>......>>>.>>>.>>>>>...<<<<<<<<<<<
<<<<<<<<<<<<...<<..<<<..<<<<<<<......<<<<<<<<.>>>>
>>>>.......>>>>>>>..>>>.........>>>>>>..>>>>>>>>>>
>.....<<.......>>.........<...<<<<<<..>>>>>>....<<
<...<<.<<<<<<<<<<<<<<<<<<<<<<<.<<<<..>>>>.>>>>>>.>
>>.>>>>>>>>>>>.>>>...>>.>>.>................>.....
...>>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>><
<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>....
.>>>...<<....>>...<<<<<<<<....>>>>>>>>..<<<<<...<<
<..<<.{.[[..>>..>>>....>>>>>.<<<<<<<<<.<<<<......>
>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<...<<<<<<.....
<<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<
..<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>
......>>>>>>......>.>>..<<<<<<....<.<<<....>>>.><<
<<<<<<<<...<<<.<<<<<<<<<...<<<....<<<..<.<<<..<<<<
.<.<.....>.>.>>>>>>>.>..>>>..>.>>...>>>>>>>...<<<<
<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>.>>>..<<<<.
<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<
<<(((.......<<<<<.....<<..........<<<.<<<<<<<<<<..
.....<<<<<.<<.....................>>.........<<...
...>>...>>>>>...>>>>>>>>>>>>>..........))).>>...>>
>>>..>>>...>>>>>>><<<<<<.<<<....................]]
.}..............>>>>>>>>>....>>>>>>.<.<<<<<<<<.<<.
.....<<<<.<<<<....>>>>>>>>...>>>>>>>>>>..>.....>>>
>>><<<....<<.....<<<<<<.......>>>>>>.<<<.....<<<<<
.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<..
..<<<....>>>..........<<.<<<<<<<<<...>>>>>>>>>>>..
....>>....>>...<<<<<........>>>>>))<<<<....<<<<...
<<<<<<<<....>>>>>>>>..<<<....>>>...<..<<<<<<<...<<
<<<<<<<<<<<<<<<<<<<<<..{{{..>>>>>>.....<<<<.<<<<.<
<<<.....<<<.....>>>.....>>>>>>>>..>>>>......<<<<<<
<.......>>>>>>>>>>>.>.>>>>>>>>>>>>.........>>>>>>>
..>..........>..>>>.>>>>>>>>..>>.....<<......>>>>>
>>.<<<<.....>>>>..>>>....<<<<.....<<<<<<<.<<......
.........<<<<<....<<..>>.....>>>>><<.<<<<<<<<<<<..
.<<<<<..>>>>>........>>>>>..>>>>>>.>>............<
<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.....>>>
>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<<<<..
..>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>.....
...<...........<<<<<.......>>>>>.....>.....>>....>
>.>>>>>>>.....>>.>>>>>>>..>>>>>>...>>>....<<<<<...
.....>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[..<<<<
<.<<<<<<<<<.<<<<<<<<<<<<.<<<<..........<<<<<..<<<.
.>>>............>>>>>.>>>>.>>.>>>>>>>>>>...<<<<<..
...<<<<..<<.<.<<<<....>>>>.>>>..............<<<<<<
<<<<<.....>>>>>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>
>>>>...<<<.....>>>..<<<<<<...........>>>>>>..<<...
<<<<<<<...<<<<<<.......>>>>>>.....<<...(((>>....>>
>>>>>...<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))
.......((((((..(((..>>>>>>.)))))))))..........]]]]
..}}]]]].......<<.<...<<<<<<...<<.......>>...>>>>>
>....>.>.>.........<<<.<<<<<<..<.<.<<<<<......>>>>
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<<<<<<....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..
<<<..<.<<<<<.................>>>>>.><<<<....<<<<..
..<<.<<<<<<<}}}.>>>>>..>>.>>...>>>>...>>>><<<<<...
<<<<<...........>>>>>...>>>>>.>>>...>.>>>>>>......
<<<<<<...<<<<....<<<........<<<<<..<<<<..>>>>.>>>>
>.......>>>...<<<..<<<<....<<<<<<<<<........>>>>>>
.>>>...>>>>..>>>..............>>>>....>>>>>>.<<<<<
.<.............>....<<.<<<<<<<.<<.....<<<<....<<<<
<......>>>>>...>>>>....>>....>>>>.>>>.>>..>>>>>..
Receptor-Ligand Complex Structure
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PDB7toq Ribosome inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM.
Resolution3.1 Å
Binding residue
(original residue number in PDB)
S76 A77 S78 E131 T135 S138 V139
Binding residue
(residue number reindexed from 1)
S2 A3 S4 E30 T34 S37 V38
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7toq, PDBe:7toq, PDBj:7toq
PDBsum7toq
PubMed35589706
UniProtG1SMR7|RL12_RABIT Large ribosomal subunit protein uL11 (Gene Name=RPL12)

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