Structure of PDB 4xej Chain AL02 Binding Site BS01 |
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| >4xej Chain A23S (length=2876)
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agaugguaagggcccacgguggaugccucggcacccgagccgaugaagga
cguggcuaccugcgauaagccagggggagccgguagcgggcguggauccc
uggauguccgaaugggggaacccggccggcgggaacgccggucaccgcgc
uuuuugcgcggggggaaccuggggaacugaaacaucucaguacccagagg
agaggaaagagaaaucgacucccugaguagcggcgagcgaaaggggacca
gccuaaaccguccggcuuguccgggcggggucguggggcccucggacacc
gaauccccagccuagccgaagcuguugggaagcagcgccagagaggguga
aagccccguaggcgaaagguggggggauaggugaggguacccgaguaccc
cgugguucguggagccaugggggaaucugggcggaccaccgccuaaggcu
aaguacuccgggugaccgauagcgcaccaguaccgugagggaaaggugaa
aagaaccccgggaggggagugaaauagagccugaaaccgugggcuuacaa
gcagucacggccccgcaagggguuguggcgugccuauugaagcaugagcc
ggcgacucacggucgugggcgagcuuaagccguugaggcggaggcguagg
gaaaccgaguccgaacagggcgucuaguccgcggccguggacccgaaacc
gggcgagcuagcccuggccagggugaagcuggggugagacccaguggagg
cccgaaccggugggggaugcaaaccccucggaugagcuggggcuaggagu
gaaaagcuaaccgagcccggagauagcugguucuccccgaaaugacuuua
gggucagccucaggcgcugacuggggccuguagagcacugauagggcuag
ggggcccaccagccuaccaaacccugucaaacuccgaagggucccaggug
gagccugggagugagggcgcgagcgauaacguccgcguccgagcgcggga
acaaccgagaccgccagcuaaggcccccaagucugggcuaagugguaaag
gauguggcgccgcgaagacagccagggguuggcuuagaagcagccauccu
uuaaagagugcguaauagcuccuggucgaguggcgccgcgccgaaaauga
ucggggcuuaagcccagcgccgaagcugcgggucugggggaugaccccag
gcgguaggggagcguucccgaugccgaugaaggccgacccgcgagggcgg
cuggagguaagggaagugcgaaugccggcaugaguaacgauaaagagggu
gagaaucccucucgccguaagcccaaggguuccuacgcaauggucgucag
cguaggguuaggcgggaccuaaggugaagccgaaaggcguagccgaaggg
cagccgguuaauauuccggcccuucccgcaggugcgauggggggacgcuc
uaggcuagggggaccggagccauggacgagcccggccagaagcgcagggu
gggagguaggcaaauccgccucccaaaagcucugcgugguggggaagccc
guacgggugacaaccccccgaagccagggagccaagaaaagccucuaagc
acaaccugcgggaacccguaccgcaaaccgacacaggugggcgggugcaa
gagcacucaggcgcgcgggagaacccucgccaaggaacucugcaaguugg
ccccguaacuucgggagaaggggugcucccuggggugaugagcuccgggg
agccgcagugaacaggcucuggcgacuguuuaccaaaaacacagcucucu
gcgaacucguaagaggagguauagggagcgacgcuugcccggugccggaa
ggucaaggggaggggugcaagccccgaaccgaagccccggugaacggcgg
ccguaacuauaacgguccuaagguagcgaaauuccuugucggguaaguuc
cgaccugcacgaaaagcguaacgaccggagcgcugucucggcgagggacc
cggugaaauugaacuggccgugaagaugcggccuacccguggcaggacga
aaagaccccguggagcuuuacugcagccugguguuggcucuuggucgcgc
cugcguaggauaggugggagccugugaacccccgccuccggguggggggg
aggcgccggugaaauaccacccuggcgcggcuggggccuaacccucggau
ggggggacagcgcuuggcgggcaguuugacuggggcggucgccuccuaaa
agguaacggaggcgcccaaagguccccucaggcgggacggaaauccgccg
gagagcgcaaggguagaagggggccugacugcgaggccugcaagccgagc
aggggcgaaagccgggccuagugaaccgguggucccguguggaagggcca
ucgaucaacggauaaaaguuaccccggggauaacaggcugaucucccccg
agcguccacagcggcggggagguuuggcaccucgaugucggcucgucgca
uccuggggcugaagaaggucccaaggguugggcuguucgcccauuaaagc
ggcacgcgagcuggguucagaacgucgugagacaguucggucucuauccg
ccacgggcgcaggaggcuugaggggggcucuuccuaguacgagaggaccg
gaagggacgcaccucugguuucccagcugucccuccaggggcauaagcug
gguagccaugugcggaagggauaaccgcugaaagcaucuaagcgggaagc
ccgccccaagaugaggccucccacggcgucaagccgguaaggacccggga
agacuacccgguggaugggccggggguguaagcgccgcgaggcguugagc
cgaccggucccaaucguccgaggucu |
<<<......<<<<<<<<<<<.....<<..<<<<<<<<<<<<......<<<
<<<.((..((.>>>.....<<<<<<<..<<<))..)).>>>.....>>>>
>>>...>>>....<<<....>>><<<<<<<<....>>>>>>>>.<<<<<<
.....>>>>>>.>>...<<<<<<.....<<....>>......>>>>>.>.
........<<....>>...<<<<<.....<<.....>>....>>>>>...
<<<....<<<<<<<<.....>>>>>>>>......<<<<<<<<<....<<<
...<<<<<.<<<<.<<<...<<<<<......>>>>>((......<<<...
..))>>>...>>>...>>>>..>>>>>..>>>>>>>>>.>>>.....<<<
<<<<<<.......>>>>>>>>>......<<<<<..((((>>>>>..>>>.
.....>>.>>>>>>.>>...............<<....>>....>>....
.....<<<<....>>>>..................>>>>>>>>>>>....
...<<<<<<<<<<<....>>>>>>>>>>>...<............>.<<<
<<<....<<<<<<<<<<<<<..<<<...<<<.....>>>...>>>...<<
....>>..<<<<.....>>>>.....>>>>>>>>>>>>>..<<.<...<<
<<<<....<<<<<<<<<<..<<<....<<<<<<......>>>>>>.....
>>>...<<<..<<<<........>>>>.>>>....>>>>>>>>>>..<<<
.....>>>......>>>>>>......>.>>..<<<<<<....<<<<<...
.>>>>><<<<<<<<<.....<<<<<<<<<...<<<...<<<<<<<<...<
<<<<<......>>>>.>>...>>>>>>>>..>>.>...>>>>>>>>>...
..>>>>>>>.>>..<<<<<<<.<<......>>.>>>>>>>.....<<<..
....>>>...<<<<.<<<...<<<(((.....<<<<<<...........<
<..<<<<<<<<<........<<<<..<<..<<<<.......>>>>..>>.
.........<<......>>...>>>>....>>>>>>>>>.>>........
..)))......>>>>>>.>>>...>>>>>>><<<<<<<<.....>>>>>>
>>....>>>>>>..<<<<<...<<<......<<<<<.<<<....>>>>>>
>>...>>>..>>>>>........>>>>>><......<<.....<<<<<<.
......>>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.
>>>>>>....((<<<<.<<...<<<...<<<....>>>...>>>...>>.
..<<<<<........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<
<.<<<..<<<<<.<<<<.<<..[[[[...>>>>>><<<...<<<<<<<<<
<<<<<<<.<<.....>>>>>>>>>....>>>>>>>>>..>>>....<<<<
....>>>>......>>>>>...>>>..>>>>>.........>>>>...>>
...>>>>>>>>>>>>>>>..>>.....<<......>>>>>>>.<<<<<..
..>>>>>..>>>>..<<<<....<<<<<<<<.<<.........<.....<
<<<<...............>>>>><<<<<<<<<<<<.....>>>>>>>>>
>>>............<<<<<<<<<..<<<.........>>>..<<<<<<<
.....<<<....>>>.......>>>>>>>.<<<<<.<<<..<<<<<<<..
<<<...<<...<<<<<....>>>>>...>>...>>>>>>>>..>>>>><<
<<<<.......>>>>>>........<...........<<<<<<.....>>
>>>>.....>....>>>>>..>>.>>>>>>>..>..>>.>>>>>>>>.>>
>>>>.....>.....<<<<<........>>>>>..<<<<<<<<.<<<...
......<<<<.<<<<<<..<<<<<.<<<.<<<<<.<<<<.<<<<<<<<<<
<.<.........<<<<<..<<<......<<<<<<<<....>>>>>>>>..
.>>>............>>>>>>.>>>>>>>>>>>>>>>...<<<<<....
>>>>>....>>>>>.>>>..>>>>>..<<<<.....>>>><<<<<<....
.......>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>.
....<....(((.>....>>>>>>>...<<<<..<<<......>>>..>>
>>.<<<....>>>.>>))).......<<<<<<<.<<..))))..>>>>>>
>>>.............>>>>..>>>>>>.......<<<<...<<<<<<..
.<<.......>>...>>>>>>....>>>.>.......<.<<<..<<<<<.
.<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....>>
>>>......>>>..>....<<<<<<<....>>>.>>>>........>>>>
>>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>
>>>>>>.<<<<<...<<<<...<<<<<<<<<<<]]]]>>>>>>...>>>>
>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....>
>>.>>>>.......>>>>>>>...<<<.....>>>.....<<<<<<<<<.
......>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>
>..>>>>>.>>>...>>>>....>>> |
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| PDB | 4xej Initiation of translation in bacteria by a structured eukaryotic IRES RNA. |
| Resolution | 3.8 Å |
Binding residue
(original residue number in PDB) | K4 K7 P8 Y9 P11 S12 R13 R14 F15 F21 E28 E30 K38 K39 R43 N44 N45 Q46 G47 R48 I49 T50 V51 R52 R54 G55 H58 K59 R60 L61 Y62 R63 Y84 P86 N87 R88 D99 G100 E101 K102 E148 P149 K150 K151 K154 L155 A156 R157 A158 A159 T161 Y172 L177 P178 S179 E181 R183 A199 K202 V205 L206 G207 K208 A209 G210 R211 S212 R213 W214 R218 P219 H220 V221 R222 G223 A225 M226 N227 P228 V229 D230 H231 H233 G235 E237 G238 R239 A240 P241 R242 R244 P246 S248 P249 W250 W252 Q253 T254 K255 G256 L257 K258 T259 R260 K261 R262 R263 K264 P265 S266 R268 F269 |
Binding residue
(residue number reindexed from 1) | K3 K6 P7 Y8 P10 S11 R12 R13 F14 F20 E27 E29 K37 K38 R42 N43 N44 Q45 G46 R47 I48 T49 V50 R51 R53 G54 H57 K58 R59 L60 Y61 R62 Y83 P85 N86 R87 D98 G99 E100 K101 E147 P148 K149 K150 K153 L154 A155 R156 A157 A158 T160 Y171 L176 P177 S178 E180 R182 A198 K201 V204 L205 G206 K207 A208 G209 R210 S211 R212 W213 R217 P218 H219 V220 R221 G222 A224 M225 N226 P227 V228 D229 H230 H232 G234 E236 G237 R238 A239 P240 R241 R243 P245 S247 P248 W249 W251 Q252 T253 K254 G255 L256 K257 T258 R259 K260 R261 R262 K263 P264 S265 R267 F268 |
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| Enzyme Commision number |
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