Structure of PDB 8bqs Chain AL Binding Site BS01

Receptor Information

>8bqs Chain AL (length=218) Species: 312017 (Tetrahymena thermophila SB210)

GYIQRSNIHEEAPNTSVEAKHHNKTFYDPILDIDEDLKDDIRLYGRDKPD
ELDFTDVWESSYQNIICPEYFYHFWFCGIVYSFEPEWTINYPFEKGPLSP
LFRGEHALRRYPTGEERCIACKLCQSACPARAITIETEPRPDGSRRTVRY
DIDMTKCIYCGFCQEACPVDAIVEGPNYEQTAYLHEDLFYDKYKLLENGD
KWEPQIARNIEYLINQPL

Ligand information

• Ligand ID: SF4
• InChI: InChI=1S/4Fe.4S
• InChIKey: LJBDFODJNLIPKO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 2.0.7: [S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
  CACTVS 3.385: S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
• Formula: Fe4 S4
• Name: IRON/SULFUR CLUSTER
• PDB chain: 8bqs Chain AL Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8bqs Structural basis of mitochondrial membrane bending by I-II-III2-IV2 supercomplex
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): C136 I137 C139 K140 C142 Y168 C185 P186 A189 I190
• Binding residue (residue number reindexed from 1): C118 I119 C121 K122 C124 Y150 C167 P168 A171 I172
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0003954 NADH dehydrogenase activity
• GO:0016651 oxidoreductase activity, acting on NAD(P)H
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:0032981 mitochondrial respiratory chain complex I assembly

Cellular Component

• GO:0005739 mitochondrion
• GO:0016020 membrane

External links

• PDB: RCSB:8bqs, PDBe:8bqs, PDBj:8bqs
• PDBsum: 8bqs
• UniProt: I7MDW5