Structure of PDB 6zsa Chain AL Binding Site BS01

Receptor Information

>6zsa Chain AL (length=164) Species: 9606 (Homo sapiens)

DPPPSTLLKDYQNVPGIEKVDDVVKRLLSLEMANKKEMLKIKQEQFMKKI
VANPEDTRSLEARIIALSVKIRSYEEHLEKHRKDKAHKRYLLMSIDQRKK
MLKNLRNTNYDVFEKICWGLGIEYTFPPLYYRRAHRRFVTKKALCIRVFQ
ETQKLKKRRRALKA

Ligand information

>6zsa Chain AA (length=924)

auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaaca
agcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacc
cccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaac
uaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggu
cacacgauuaacccaagucaauagaccggcguaaagaguguuuuagauca
caauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaa
auagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagac
ccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacagu
ucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaa
ggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucga
uaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccauc
uucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaa
agacguuaggucaagguguagcccaugagguggcaagaaaugggcuacau
uuucuaccccagaaacgauagcccuuaugaauaagggucgaagguggauu
uagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgc
guacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacua
aaaccccuacgcauuuauauagaggagacaagucguaacaugguaagugu
acuggaaagugcacuuggacgaac

..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<
..<......>......<<........<<<.<..<<..>>.>..>>>...<
<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<
<....>>>.....>>>>>>>........<<<....<<<......>>>..>
>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>))...
....)))..>>>>>..>>.>>>>>>..<<<((.....<<<<..<<<<...
...<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>......
......<<<....>>>>>>>>>.....>>>>...>>>>....<<<<<<..
.<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<
<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>
>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<<<<.....<<.
.......>>..........<<<<<<<.......<<.<<<..<<<<<<.<.
....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.
....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>....
.<<<<.....>>>>.<....<<<<<<<....>>>>>>>....>.....>>
>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>
>>.>>....<..<<.<...<<<<<<..<<<<<..<...<<<..<<.....
>>...>>>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<
<<<....>>>>>>>>>........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zsa Structural basis of mitochondrial translation.
• Resolution: 4.0 Å
• Binding residue (original residue number in PDB): N99 K101 T122 R123 R128 L132 K135 Y139 H142 H146 R147 K150 H152 R154 Y155 L157 M158 D161 Q162 K165 K168 Y195 Y196 R197 R198 H200 R201 R202 F203 K206 K207 C210 F214 K222
• Binding residue (residue number reindexed from 1): N34 K36 T57 R58 R63 L67 K70 Y74 H77 H81 R82 K85 H87 R89 Y90 L92 M93 D96 Q97 K100 K103 Y130 Y131 R132 R133 H135 R136 R137 F138 K141 K142 C145 F149 K157

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005759 mitochondrial matrix
• GO:0005761 mitochondrial ribosome
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zsa, PDBe:6zsa, PDBj:6zsa
• PDBsum: 6zsa
• PubMed: 32812867
• UniProt: P82914|RT15_HUMAN Small ribosomal subunit protein uS15m (Gene Name=MRPS15)