Structure of PDB 8cq7 Chain AK Binding Site BS01

Receptor Information
>8cq7 Chain AK (length=86) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKGTPSLGKRHNKSHTLCNRCGRRSFHVQKKTCSSCGYPAAKMRSHNWAL
KAKRRRTTGTGRMAYLKHVTRRFKNGFQTGVAKAQT
Ligand information
>8cq7 Chain 1 (length=3216) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggag
gaauguggcacggcuucugcuguguguuauagccucugacgauacugcca
gccuagaccgaggacugcgguuuaccuaggauguuggcauaaugaucuua
agucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgagug
uuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggggcc
cauuagggugcaccaucgaccgauccugauguguucggauggauuugagu
aagagcauagcuguugggacccgaaagauggugaacuaugccugaauagg
gugaagccagaggaaacucugguggaggcucguagcgguucugacgugca
aaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccaucu
aguagcugguuccugccgaaguuucccucaggauagcagaagcucguauc
aguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaugacc
uuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaauu
gaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaagc
agaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaaug
cacgcucaucagacaccacaaaagguguuaguucaucuagacagccggac
gguggccauggaagucggaauccgcuaaggaguguguaacaacucaccgg
ccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuuaua
cuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcguggag
gucagugacgaagccuuugcuguaaagcugggucgaacggccucuagugc
agaucuuggugguaguagcaaauauucaaaugagaacuuugaagacugaa
guggggaaagguuccaugucaacagcaguuggacauggguuagucgaucc
uaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaacc
aucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuuca
cggcaacguaacugaauguggagacgucggcgugagcccugggaggaguu
aucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggagau
ggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcgcu
uacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaaguc
guacucauaaccgcagcaggucuccaagguuaacagccucuaguugauag
aauaauguagauaagggaagucggcaaaauagauccguaacuucgggaua
aggauuggcucuaaggaucgguuuaacgaucaacuuagaacugguacgga
caaggggaaucugacugucuaauuaaaacauagcauugugauggucagaa
agugauguugacacaaugugauuucugcccagugcucugaaugucaaagu
gaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacucuc
uuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaugga
uuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagcca
agggaacgggcuuggcagaaucagcggggaaagaagacccuguugagcuu
gacucuaguuugacauugugaaaagacauggaggguguagaauaaguggg
agcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuuauu
caaugaagcggagcuggaggucaaacuccacguucuagcauuaagcccuc
ugggcgauccggguugaagacauugucagguggggaguuuggcuggggcg
gcacaucuguuaaacgauaacgcagguguccuaagggggacucauggaga
acagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuugauu
uucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagucc
cucggaauuugaggcuagaggugccagaaaaguuaccacagggauaacug
gcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucgau
gucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauugu
ucacccacuaauagggaacgugagcuggguuuagaccgucgugagacagg
uuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuuagu
acgagaggaaccguucauucagauaauugguuuuugcggcugucugauca
ggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucuaa
gucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuuagau
ggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacgg
ugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaaugucaa
caugcgcggggauaaauccuuugcauacgacuuagauguacaacggagua
uuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcuc
uuguugucugauuugu
.......................<<<<<<.....<......>......>>
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....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>
>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]...............................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<..<<<<.
.>>>>..>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<
<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.
>>>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>>>>
>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<
..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<<<
<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.>>
....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<
<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<......
..>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>.
..>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...<<
<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>>>
>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<......
>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<.....>
>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((.....<
<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<.<
<<...<<.........>>...>>>.........<<......>>...>>>>
>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>..>
>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<<<
<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>....
....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<...
..<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<
...<<....<<<....>>>..........<<<<<<....>>>>>>.....
.>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<.....<
<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<..
{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>....>
>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>>>
>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>>>
>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<
<.....<<<<<<<.<<...............<<<<<..............
.>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>........
....<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<...
..>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<.....<
<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>>>
........<...........<<<<<.......>>>>>.....>.....>>
....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<
<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[.
.<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<................
............................>>.>...>>>>>>>>>>...<<
<<<.....<<<<..<<<<<......>>>>>..............<<<<..
.>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<.....>
>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<
.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<<<
<.......>>>>.>>>>.<<<....>>>.>>))).......((((((..(
(((.>>>>>>))))))))))..........]]]]..}}]]]].......<
<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>......
.<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<.....
....>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.>>
>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<.....
............>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}.>
>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<...........>
>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<.<.....
<<..........<<<......>>>......>>.......<<<<<<...<<
<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............>
.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.<
<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>>
>.>>>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cq7 Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.2 Å
Binding residue
(original residue number in PDB)
G2 K3 G4 T5 P6 S7 L8 G9 K10 R11 H12 N13 K14 S15 H16 R24 R25 S26 H28 Q30 S35 K43 M44 R45 H47 N48 W49 K52 R55 R56 T58 K75 N76 Q86
Binding residue
(residue number reindexed from 1)
G1 K2 G3 T4 P5 S6 L7 G8 K9 R10 H11 N12 K13 S14 H15 R23 R24 S25 H27 Q29 S34 K42 M43 R44 H46 N47 W48 K51 R54 R55 T57 K74 N75 Q85
External links
PDB RCSB:8cq7, PDBe:8cq7, PDBj:8cq7
PDBsum8cq7
PubMed
UniProtA0A1D8PF45|RL37B_CANAL Large ribosomal subunit protein eL37 (Gene Name=RPL37B)

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