Structure of PDB 7qi6 Chain AJ Binding Site BS01

Receptor Information
>7qi6 Chain AJ (length=108) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATLNQMHRLGPPKRPPRKLGPTEGRPQLKGVVLCTFTRKPKKPNSANRKC
CRVRLSTGREAVCFIPGEGHTLQEHQIVLVEGGRTQDLPGVKLTVVRGKY
DCGHVQKK
Ligand information
>7qi6 Chain AA (length=954) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaag
ggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagcc
acacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaagu
uuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccacc
gcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuu
uagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaa
cuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaac
acacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagc
ccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacga
gccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuaga
ggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugc
ucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaagu
aagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagg
uggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuu
augaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagu
gcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccucc
ucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauaua
gaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacg
aacc
..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<
..<......>......<<.......<<<<.<..<<<.....>>>.>..>>
>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.
>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>
>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>
)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..
<<<<...............<<<<<<......<<<.<<<.<<<......>>
>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...
>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>
..........<.<<<<<......))..>>>>>.>.>>>.<<.......<<
<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<
..<<<<<<<<<<.....<<........>>..........<<<<<<<....
...<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>
..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>
>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<<
<.......>>>>>>>....>.....>>>>>.....<<<<<<<........
.>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<
<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.
>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qi6 Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications.
Resolution2.98 Å
Binding residue
(original residue number in PDB)
A31 T32 N34 Q35 M36 R38 P41 P42 K43 R44 R47 K48 G54 R55 P56 Q57 K59 K71 K72 N74 S75 A76 N77 R78 K79 S86 G97 E98 E111 G112 R114 Q116 D117 P119 K122 K129 H134 K137
Binding residue
(residue number reindexed from 1)
A1 T2 N4 Q5 M6 R8 P11 P12 K13 R14 R17 K18 G24 R25 P26 Q27 K29 K41 K42 N44 S45 A46 N47 R48 K49 S56 G67 E68 E81 G82 R84 Q86 D87 P89 K92 K99 H104 K107
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005761 mitochondrial ribosome
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7qi6, PDBe:7qi6, PDBj:7qi6
PDBsum7qi6
PubMed38769321
UniProtO15235|RT12_HUMAN Small ribosomal subunit protein uS12m (Gene Name=MRPS12)

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