Structure of PDB 6zse Chain AJ Binding Site BS01

Receptor Information

>6zse Chain AJ (length=108) Species: 9606 (Homo sapiens)

ATLNQMHRLGPPKRPPRKLGPTEGRPQLKGVVLCTFTRKPKKPNSANRKC
CRVRLSTGREAVCFIPGEGHTLQEHQIVLVEGGRTQDLPGVKLTVVRGKY
DCGHVQKK

Ligand information

>6zse Chain AA (length=924)

auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaaca
agcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacc
cccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaac
uaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggu
cacacgauuaacccaagucaauagaccggcguaaagaguguuuuagauca
caauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaa
auagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagac
ccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacagu
ucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaa
ggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucga
uaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccauc
uucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaa
agacguuaggucaagguguagcccaugagguggcaagaaaugggcuacau
uuucuaccccagaaacgauagcccuuaugaauaagggucgaagguggauu
uagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcgc
guacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacua
aaaccccuacgcauuuauauagaggagacaagucguaacaugguaagugu
acuggaaagugcacuuggacgaac

..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<..<.<<<.<<<
..<......>......<<........<<<.<..<<..>>.>..>>>...<
<<<....<<...<<<....>>>..>>......>>>>.<<...>>.>>.<<
<....>>>.....>>>>>>>........<<<....<<<......>>>..>
>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>))...
....)))..>>>>>..>>.>>>>>>..<<<((.....<<<<..<<<<...
...<<<<<<......<<<.<<<.<<<......>>>..>>>.>>>......
.......<<....>>.>>>>>>.....>>>>...>>>>....<<<<<<..
.<<...<<<<.<.....>.>>>>...>>>>>>>>..........<.<<<<
<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>
>>>>><<<<<.<<<<<<<...<<<.<<<<...<<<<<<<<<<.....<<.
.......>>..........<<<<<<<.......<<.<<<..<<<<<<.<.
....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.
....>...>>>...>>>>>>>>....>>>>>>>..>>.>>>>>>>>....
.<<<<.....>>>>.<....<<<<<<<....>>>>>>>....>......>
>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>>
>>.>>....<..<<.<...<<<<<<..<<<<<..<...<<<..<<.....
>>...>>>....>..>>>>>.>>>>>>....>.>>...>.....<<<<<<
<<<....>>>>>>>>>........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zse Structural basis of mitochondrial translation.
• Resolution: 5.0 Å
• Binding residue (original residue number in PDB): A31 T32 N34 Q35 P41 P42 K43 R47 G54 R55 P56 Q57 K59 K71 K72 N74 S75 A76 N77 R78 K79 G97 E98 E111 G112 R114 Q116 D117 P119 K122 H134 K137 K138
• Binding residue (residue number reindexed from 1): A1 T2 N4 Q5 P11 P12 K13 R17 G24 R25 P26 Q27 K29 K41 K42 N44 S45 A46 N47 R48 K49 G67 E68 E81 G82 R84 Q86 D87 P89 K92 H104 K107 K108

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:0015935 small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zse, PDBe:6zse, PDBj:6zse
• PDBsum: 6zse
• PubMed: 32812867
• UniProt: O15235|RT12_HUMAN Small ribosomal subunit protein uS12m (Gene Name=MRPS12)