Structure of PDB 6z1p Chain AJ Binding Site BS01

Receptor Information

>6z1p Chain AJ (length=178) Species: 312017 (Tetrahymena thermophila SB210)

CSRGVFQLRKIQLQFCDFGGSSKGVRDFMNSDTVKEFMVKNPQIQFEFIM
RRNKHPFLSAQYINGFVKDISLKNYERDDILDEFNRARQSFGRKALPFAG
KKVYTARPSIQGKWTPLTWSTYPKVELQMVREIKEPQEEIQLVDNVNKNV
ELVNYKDFVHAFLKDKKINEEFNSQIVQ

Ligand information

>6z1p Chain Ab (length=2237)

uaguaaauuucaauaaguuuuugaaauugaaaaauagagaucuaccucua
aaacuuguaaaguuuaaauucaauagaaaacaguaccgcgagggaaaggu
gaaaagauuuuauaauaucuuaaaagaaccugaaauuuagugcuaaauac
aguuaaagcuuuauuguuuuaacguaccuuuugcauaaugggcuagcgag
uuuauauaauuagcgaguaauuuaaauuuuauaaaauuacgaaucgauag
aauaaauaguuaauuauauaagacccgaagcuaagugaucuaauuaugau
uagauuaaggguauuuauaccugaggaucgaacucuuaaauguugcaaaa
uuuugggauaaauuguaauuaggggugaaaggcuuaucaaacuuaguuau
agcugguuuuccacgaaaccuauuuaaguaggguguuauuuuuuauaaua
auuagguuuaaauaacuauaucuauaauuaauuuguuaauuauaaaauua
guauauaauaauuaguuauuauuagauaauaaccagacuauuagcgcuaa
gguuuauagucaagagagaaacagcucagauuaaacaauaaggucuuuaa
aaauaaauaauuauggagauuauuuuuguuaauacuaauaagauguaggc
uuggaagcagccaucauuuuaaaaaagcguaaaagcuuaauauuagauaa
auuaauguuaaaaauuaauugauacuuaaauaaucauagaugaagagaga
auaauuuuuauuuaccgaauugauaaaucgaaagaugguaguggaacguu
uuguauaaaaaaauaaaauugugaaauuuuauauuuuaucaauauugaua
augcuagcaugaguaguagacauaaugugagaaucauuaucgccugauau
acaaggguuacuaaauuugauaaucuuauuuaguguaagucgauuucuaa
gauauaaaaguauauuguuaucaaugaauauaaaauauaaaauaucuaau
aaacuacuuuuuauauuauauaaaauuuuuuauaauauaggugguuuagu
gacuggaaauguuuauauuuuauuaaaucguacuaacucuaacacaagug
uuuaaguagaauauauaauggcgaaggaguaaaaaguauugaaggaacua
ggcaaaauaacccuguaacuuugggagaaagggggcuuuuaagcaacuga
aaagagagaguagcgacuguuuaauaaaaacauaagauuuugcaaaauuu
aaauaugauguauaaaaucugacaccugcccggugcugcaaggugaaucu
auuuuaguuaacgcugaaauauuaaaccccaguaaacggcggccguaacc
cugacgguccuaagguagcaaaauuccuuggcggguaaguuccguccugc
augaaugguguaacgacugcucugcugucuccaauacuugcucuacgaaa
uugaacuuuccgugaagaugcggcaauauuacaacuagacgggaagaccc
uaugcaccuuuacuguuaucuguaauuaauuuaauuacauauaaauaaaa
uaaauuuuaauuauuuuuguuauugaaagacaguuugacuggggcggucu
ccuccuaaaaaguaacggaggaguauaauaauuugggguaucuuauuuua
auugagaucaauauuagaaugaauauacuaaauuugauuagaguacaaac
aaguauucuaaggauauaugucugucauauugacccgauauaauuuagua
gaaaauauaucgaucaacgaauaaaagguacgcuagggauaacaggcuua
uggguuuugagaguucuuauuaauaaacccguuuggcaccucgaugucgg
cucaucacauccugaugguggacaaucuaucaaggguccggcuguucgcc
gguuaaagugguacgugagcuggguuuaaaacgucgugagacaguuuggu
cccuaucuguuguaauuacaagaaaauaaauaagaauuaacuuuaguacg
agaggacuaggaaaauuuaaucacugguuugaaaauuacuuuaauaaaua
aaaguacgguuuuuaagcuaaauuaaacaagauaauugcugaauucuaua
uaagcaagaaucuaacuuauauuauuuucuaauaaacuuuuuaaagacua
uauuauuuaaguauauuuauuaagagucauuauaacuaauaaauauaaau
auacuaaauguuuaauaaucacuacaguuuaguuuuu

.....<<<<<<<<.......>>>>>>>>......<<<<<..((((>>>>>
...................................<<....>>.......
..................................................
.<<<<<<<<......>>>>>>>>...<.<........>.>.<<<<<<...
.<<<<<<<<<<<<...<<<..................>>>...<<....>
>........>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<
..<<<...<<<<<<..>>>>>>....>>>...<<<..<<<<........>
>>>.>>>....>>>>>>>>>...<<<.....>>>......>>>>>>....
..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<....<<<<<<
<<<.....<..<<.<<<<..<..<<<<<<<<....>>>>>>>>..>..>>
>>..>>.>.....>>>>>>>>>..>>>>>>.>>..<<<<<<.<<<.....
.>>>.>>>>>>....<<<......>>>...<<<..<<<...<<<(((...
<<<<<<<..........<<<<<<<<....<<...<<<<<<..<<<..<<<
<.......>>>>..>>>.......<<<<......>>>>..>>>>>>...<
<<<<...........>>>>>..>>...>>>>>>>>...........))).
......>>>>>>>>>>...>>>.>>><<<....>>>....>>>>>><<..
<<<...<<....<<<<<<<<....>>>>>>>>...>>..>>>...>>...
..>>>>>><......<<....<<<<<<.......>>>>>><<<<....<.
<<..<....<<<<<<.............>>>>>>.......<<<.<<...
<<<....<<.....>>...>>>...>>....<<<<<<<<<<...<<...<
<<<<<<<.....<<<<<<<<....[[.[[.>>>>>>>>..>>>>>>>>..
>>.........>>>>>>>>>>.....>>>....>....<<......>>.>
>.>..<<<.....>>>...>>>>..<<<<<...<<<<<<<..<<......
..........<<<<...............>>>>.<<......>>......
......<<<<<<<<<..<<<.........>>>..<<<<<<<.....<<..
....>>.......>>>>>>>.<<<<<.<<<..<<<<<<...<<<.....<
<<<<<<<<....>>>>>>>>>....>>>.>>>>..>>>>><<<<<<....
...>>>>>>........<...........<<<<<.......>>>>>....
.>....>>>>>..>>.>>>>>>>.....>>..>>>>>>>>>>>>>>....
.>.....<.<<<........>>>.>..<<<<<<<<.<<<.<<<.....<<
<<.<.<<<<..<<<<...<<.<<<<<<<<<<.>>>>>.<.<<<<......
..........>>>>.>..>>>>>.>>....>>>>..<<<<.....>>>><
<<<<<...........>>>>>>..<<...<<<<<<<...<<<<<<.....
..>>>>>>....<<<...(((>>>...>>>>>>>...<<<<<<<<<....
..>>>>>>>>>.<<<....>>>.>>))).......<<<<<<.<<<..)))
)..>>>>>>>>>.............>>>>...>>>>>.......<<<<..
.<<<<<<...<<.......>>...>>>>>>....>>>.>.......<.<<
<.<<<<<<..<<<<<<<<........>>>>>>..>>.<<<<<.....>>>
>>.....>>>>>..>...>>>..>....<<<<<<<....>>>.>>>>...
>>>..>>>>>>>>>>>....<<<<<<<<.<<<<<.<<<..<<<.......
........>>>..>>><<<<<....<<<..<<<<<<<<<<<<...]]]].
>>>>>>..>>>>>>..>>>..>>>>>...<<<...<<<<<..........
..>>>>>...>>>..>>>>>..>>>>>>>>...<<<<.<..<<.......
>>..>....<<<<<<<<<<<.........<.......>......>>>>>>
>>>>>....>>>>........................

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6z1p Ciliate mitoribosome illuminates evolutionary steps of mitochondrial translation.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): G20 G21 R53 N54 H56 D70 K74 K95 F99 G101 K102 M130 R132 H161 K165 N170 N174
• Binding residue (residue number reindexed from 1): G19 G20 R52 N53 H55 D69 K73 K94 F98 G100 K101 M129 R131 H160 K164 N169 N173

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6z1p, PDBe:6z1p, PDBj:6z1p
• PDBsum: 6z1p
• PubMed: 32553108
• UniProt: Q22RG0