Structure of PDB 8c3a Chain AH Binding Site BS01

Receptor Information

>8c3a Chain AH (length=112) Species: 5476 (Candida albicans)

AQRVTYRRRNPYNTRSNKIKVVKTPGGKLVAQHVKKAASRVKCGDCGSAL
AGISTLRPRQYAQVSKTHKTVQRAYGGSRCANCVKERIVRAFLIEEQKIV
KRVLKEQQDKEK

Ligand information

>8c3a Chain 1 (length=3217)

ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcggag
gaauguggcacggcuucugcuguguguuauagccucugacgauacugcca
gccuagaccgaggacugcgguuuuuaccuaggauguuggcauaaugaucu
uaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcgag
uguuuggguguaaaacccguacgcguaaugaaagugaacgaagguggggg
cccauuagggugcaccaucgaccgauccugauguguucggauggauuuga
guaagagcauagcuguugggacccgaaagauggugaacuaugccugaaua
gggugaagccagaggaaacucugguggaggcucguagcgguucugacgug
caaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaaccau
cuaguagcugguuccugccgaaguuucccucaggauagcagaagcucgua
ucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaauga
ccuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuuaa
uugaacguggacaauugaaugaagagcuuuuagugggccauuuuugguaa
gcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccggaa
ugcacgcucaucagacaccacaaaagguguuaguucaucuagacagccgg
acgguggccauggaagucggaauccgcuaaggaguguguaacaacucacc
ggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuua
uacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcgugg
aggucagugacgaagccuuugcuguaaagcugggucgaacggccucuagu
gcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacug
aaguggggaaagguuccaugucaacagcaguuggacauggguuagucgau
ccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggccaa
ccaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucuu
cacggcaacguaacugaauguggagacgucggcgugagcccugggaggag
uuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccggag
auggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugcg
cuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaag
ucguacucauaaccgcagcaggucuccaagguuaacagccucuaguugau
agaauaauguagauaagggaagucggcaaaauagauccguaacuucggga
uaaggauuggcucuaaggaucgguuuaacgaucaacuuagaacugguacg
gacaaggggaaucugacugucuaauuaaaacauagcauugugauggucag
aaagugauguugacacaaugugauuucugcccagugcucugaaugucaaa
gugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacuc
ucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaug
gauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacagc
caagggaacgggcuuggcagaaucagcggggaaagaagacccuguugagc
uugacucuaguuugacauugugaaaagacauggaggguguagaauaagug
ggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuua
uucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagccc
ucugggcgauccggguugaagacauugucagguggggaguuuggcugggg
cggcacaucuguuaaacgauaacgcagguguccuaagggggacucaugga
gaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuuga
uuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuagu
cccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaac
uggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuucg
augucggcucuuccuaucauaccgaagcagaauucgguaagcguuggauu
guucacccacuaauagggaacgugagcuggguuuagaccgucgugagaca
gguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuua
guacgagaggaaccguucauucagauaauugguuuuugcggcugucugau
caggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccucu
aagucagaauccaugcuagaacgcgaugauuuugcccugcacauuuuaga
uggauacgaauaagacuuuuuagucgcuggaccauagcaggcuggcaacg
gugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaauguca
acaugcgcggggauaaauccuuugcauacgacuuagauguacaacggagu
auuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcu
cuuguugucugauuugu

.......................<<<<<<.....<......>......>>
>>>.>...{.....<<....>>..<<<<<......<<.....>>.....>
>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.........
....<<<<<...<<<<<<<<<<<<.<<<<<<<<....<<<<......>>>
>.(.......<<<......)>>>..>.>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]....}..........................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<..<<<<.
.>>>>..>>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<<<<
<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>>>.
>>>>>>>>>>........<<<....>>>.....>>>>>>>....>>>>>>
>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<
<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..<
<<<....>>>>...>>>>>.<<<<<<<<...<<....>>...>>>.>>>.
>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..
<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<<....
....>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>
>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<...
<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<.......>
>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<....
..>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<....
.>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((....
.<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<<
.<<<...<<.........>>...>>>.........<<......>>...>>
>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>.
.>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>>..<<<
<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>..
......>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<.
....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<
<<...<<....<<<....>>>..........<<<<<<....>>>>>>...
...>>....>>...<<<<<........>>>>>))<<<<.<<<<<<<....
.<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<<
..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>...
.>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...>
>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>>
>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<
<<<.....<<<<<<<.<<...............<<<<<............
...>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>......
......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<.
....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<....
.<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>>
>>........<...........<<<<<.......>>>>>.....>.....
>>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<
<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[
[..<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<..............
..............................>>.>...>>>>>>>>>>...
<<<<<.....<<<<..<<<<<......>>>>>..............<<<<
...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<....
.>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<<
<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<<
<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((.
.((((.>>>>>>))))))))))..........]]]]..}}]]]]......
.<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>....
...<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<...
......>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>.
>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<...
..............>>>>>..<<<<<...<<<<....<<<<<<<<<<}}}
.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<..........
.>>>>>...>>>>.>>>>....>>>>>>>>....<<<<<<.<<<.<....
.<<..........<<<......>>>......>>.......<<<<<<...<
<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............
>.>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.
<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>
>>.>>>>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8c3a New crystal system to promote screening for new eukaryotic inhibitors
• Resolution: 3.0 Å
• Binding residue (original residue number in PDB): A2 R4 V5 T6 Y7 R8 R9 R10 N11 P12 Y13 N14 T15 S17 V22 K24 T25 P26 G27 L30 Q33 K37 S40 R41 V42 K43 G45 A52 G53 I54 S55 T56 R58 P59 R60 Y62 A63 Q64 S66 K67 T68 K70 V72 Q73 R74 Y76 G78 N83 R88 R91 A92 I95 E96 K99 K102
• Binding residue (residue number reindexed from 1): A1 R3 V4 T5 Y6 R7 R8 R9 N10 P11 Y12 N13 T14 S16 V21 K23 T24 P25 G26 L29 Q32 K36 S39 R40 V41 K42 G44 A51 G52 I53 S54 T55 R57 P58 R59 Y61 A62 Q63 S65 K66 T67 K69 V71 Q72 R73 Y75 G77 N82 R87 R90 A91 I94 E95 K98 K101

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8c3a, PDBe:8c3a, PDBj:8c3a
• PDBsum: 8c3a
• UniProt: A0A8H6F171