Structure of PDB 6zm5 Chain AG Binding Site BS01

Receptor Information

>6zm5 Chain AG (length=312) Species: 9606 (Homo sapiens)

TYTEDFIKKQIEEFNIGKRHLANMMGEDPETFTQEDIDRAIAYLFPSGLF
EKRARPVMKHPEQIFPRQRAIQWGEDGRPFHYLFYTGKQSYYSLMHDVYG
MLLNLEKHQVIGSRWLIKEELEEMLVEKLSDLDYMQFIRLLEKLLTSQCG
AAEEEFVQRFRRSVTLESKKQLIEPVQYDEQGMAFSKSEGKRKTAKAEAI
VYKHGSGRIKVNGIDYQLYFPITQDREQLMFPFHFVDRLGKHDVTCTVSG
GGRSAQAGAIRLAMAKALCSFVTEDEVEWMRQAGLLTTDPRVRERKKPGQ
EGARRKFTWKKR

Ligand information

>6zm5 Chain AA (length=954)

auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaag
ggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagcc
acacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaagu
uuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccacc
gcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuu
uagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaa
cuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaac
acacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagc
ccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacga
gccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuaga
ggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugc
ucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaagu
aagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagg
uggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuu
augaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagu
gcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccucc
ucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauaua
gaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacg
aacc

..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<
..<......>......<<.......<<<<.<..<<<.....>>>.>..>>
>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.
>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>
>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>
)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..
<<<<...............<<<<<<......<<<.<<<.<<<......>>
>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...
>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>
..........<.<<<<.......))...>>>>.>.>>>.<<.......<<
<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<
..<<<<<<<<<<.....<<........>>..........<<<<<<<....
...<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>
..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>
>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<<
<.......>>>>>>>....>.....>>>>>.....<<<<<<<........
.>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<
<<..<<<<<......<<<....<<.....>>...>>>.......>>>>>.
>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6zm5 Mechanism of membrane-tethered mitochondrial protein synthesis.
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): F117 E118 L216 D217 R276 K277 I306 G336 S338 A339 R375 V376 R377 E378 R379 K380 K381 P382 R388 R389 K390 T392 W393 K394 K395 R396
• Binding residue (residue number reindexed from 1): F50 E51 L132 D133 R192 K193 I222 G252 S254 A255 R291 V292 R293 E294 R295 K296 K297 P298 R304 R305 K306 T308 W309 K310 K311 R312

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6zm5, PDBe:6zm5, PDBj:6zm5
• PDBsum: 6zm5
• PubMed: 33602856
• UniProt: P82933|RT09_HUMAN Small ribosomal subunit protein uS9m (Gene Name=MRPS9)