Structure of PDB 6vmi Chain AG Binding Site BS01

Receptor Information

>6vmi Chain AG (length=315) Species: 9606 (Homo sapiens)

TEDFIKKQIEEFNIGKRHLANMMGEDPETFTQEDIDRAIAYLFPSGLFEK
RARPVMKHPEQIFPRQRAIQWGEDGRPFHYLFYTGKQSYYSLMHDVYGML
LNLEKHQSHLQAKSGSRWLIKEELEEMLVEKLSDLDYMQFIRLLEKLLTS
QCGAAEEEFVQRFRRSVTLESKKQLIEPVQYDEQGMAFSKSEGKRKTAKA
EAIVYKHGSGRIKVNGIDYQLYFPITQDREQLMFPFHFVDRLGKHDVTCT
VSGGGRSAQAGAIRLAMAKALCSFVTEDEVEWMRQAGLLTTDPRVRERKK
PGQEGARRKFTWKKR

Ligand information

>6vmi Chain AA (length=944)

auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaag
gaacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagcc
acacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaagu
uuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccacc
gcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuu
uagaucacccccaauaaagcuaaaacucaccugaguuguaaaaaacucca
guugacacaaaauagacuacgaaaguggcuuuaacauaucugaacacaca
auagcuaagacccaaacugggauuagauaccccacuaugcuuagcccuaa
accucaacaguuaaaucaacaaaacugcucgccagaacacuacgagccac
agcuuaaaacucaaaggaccuggcggugcuucauaucccucuagaggagc
cuguucuguaaucgauaaaccccgaucaaccucaccaccucuugcucagc
cuauauaccgccaucuucagcaaacccugaugaaggcuacaaaguaagcg
caaguacccacguaaagacguuaggucaagguguagcccaugagguggca
agaaaugggcuacauuuucuaccccagaaacgauagcccuuaugaaacuu
aagggucgaagguggauuuagcaguaaacuaagaguagagugcuuaguug
aacagggcccugaagcgcguacacaccgcccgucacccuccucaaguaua
cuucaaaggacauuuaacuaaaaccccuacgcauuuauauagaggagaca
agucguaacaugguaaguguacuggaaagugcacuuggacgaac

..((((..<<<<<..)))).<<<<<<.<...<<<<<<<<..<.<<<.<<<
................<<........<<<.<..<<<.....>>>.>..>>
>...<<<<....<<<..<<<....>>>.>>>......>>>>.<<...>>.
>>.<<<....>>>.....>>>>>>>........<<<....<<<<....>>
>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>
)).......)))..>>>>>...>.>>>>>>....<<<((.....<<<<..
<<<<..........<<<<<<......<<<.<<<.<<<......>>>..>>
>.>>>.............<<....>>.>>>>>>.....>>>>...>>>>.
...<<<<<<...<<...<<<<.........>>>>...>>>>>>>>.....
.....<.<<<<<......))..>>>>>.>.>>>.<<.......<<<<...
.>>>>.....>>...>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<
<<<<<<<.....<<........>>..........<<<<<<<.......<<
.<<<..<<<<<<<......<<....<<<.....>>>...........>>.
....<<<....>>>.......>.>>>...>>>>>>>>....>>>>>>>..
>>.>>>>>>>>.....<<<<.....>>>>......<<<<<<.........
>>>>>>..........>>>>>.....<<<<<<<.........>>>>>>>.
....>>>...>>>>>>>>>>.>>.......<<.<...<<<<<<..<<<<<
.............<.......>.............>>>>>.>>>>>>...
.>.>>.........<<<<<<<<<....>>>>>>>>>........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6vmi Structures of the human mitochondrial ribosome bound to EF-G1 reveal distinct features of mitochondrial translation elongation.
• Resolution: 2.96 Å
• Binding residue (original residue number in PDB): F117 E118 K212 L216 K277 Q308 G336 R337 S338 R375 V376 R377 E378 R379 K380 K381 R388 R389 T392 W393 R396
• Binding residue (residue number reindexed from 1): F48 E49 K131 L135 K196 Q227 G255 R256 S257 R294 V295 R296 E297 R298 K299 K300 R307 R308 T311 W312 R315

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6vmi, PDBe:6vmi, PDBj:6vmi
• PDBsum: 6vmi
• PubMed: 32737313
• UniProt: P82933|RT09_HUMAN Small ribosomal subunit protein uS9m (Gene Name=MRPS9)