Structure of PDB 6nu3 Chain AG Binding Site BS01

Receptor Information

>6nu3 Chain AG (length=305) Species: 9606 (Homo sapiens)

EDFIKKQIEEFNIGKRHLANMMGEDPETFTQEDIDRAIAYLFPSGLFEKR
ARPVMKHPEQIFPRQRAIQWGEDGRPFHYLFYTGKQSYYSLMHDVYGMLL
NLEKHQRWLIKEELEEMLVEKLSDLDYMQFIRLLEKLLTSQCGAAEEEFV
QRFRRSVTLESKKQLIEPVQYDEQGMAFSKSEGKRKTAKAEAIVYKHGSG
RIKVNGIDYQLYFPITQDREQLMFPFHFVDRLGKHDVTCTVSGGGRSAQA
GAIRLAMAKALCSFVTEDEVEWMRQAGLLTTDPRVRERKKPGQEGARRKF
TWKKR

Ligand information

>6nu3 Chain AA (length=923)

auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucgaucaaaaggaaca
agcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagccacacc
cccacgggaaacagcagugauuaaccuuuagcaauaaacgaaaguuuaac
uaagcuauacuaaccccaggguuggucaauuucgugccagccaccgcggu
cacacgauuaacccaagucaauagaccggcguaaagaguguuuuagauca
caauaaagcuaaaacucaccugaguuguaaaaaacuccaguugacacaaa
auagacuacgaaaguggcuuuaacauaucugaacacacaauagcuaagac
ccaaacugggauuagauaccccacuaugcuuagcccuaaaccucaacagu
ucaacaaaacugcucgccagaacacuacgagccacagcuuaaaacucaaa
ggaccuggcggugcuucauaucccucuagaggagccuguucuguaaucga
uaaaccccgaucaaccucaccaccucuugcucagccuauauaccgccauc
uucagcaaacccugaugaaggcuacaaaguaagcgcaaguacccacguaa
agacguuaggucaagguguagcccaugagguggcaagaaaugggcuacau
uuucuaccccagaaacgauagcccuuaugaaauaagggucgaagguggau
uuagcaguaaacuaagaguagagugcuuaguugaacagggcccugaagcg
cguacacaccgcccgucacccuccucaaguauacuucaaaggacuuaacu
aaaaccccuacgcauuuauauagaggagacgucguaacaugguaagugua
cuggaaagugcacuuggacgaac

..((((..<<<<<<.)))).<<<<<<.<...<<<<<<<<..<.<<<.<<<
..<......>......<<........<<<....<<..>>....>>>...<
<<<....<<<..<<<....>>>.>>>......>>>>.<<...>>.>>.<<
<....>>>.....>>>>>>>........<<<....<<<<....>>>>..>
>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>))...
....)))..>>>>>...>.>>>>>>..<<<((......<<<..<<<<...
...<<<<<<........<...<.<<........>>..>...>........
.......<<....>>.>>>>>>.....>>>>...>>>....<<<<<<<..
.<<...<<<<.........>>>>...>>>>>>>>..>.......<.<<<<
<..))..>>>>>.>.>>>.<<.......<<<<....>>>>.....>>..>
>>>>><<<<<.<<<<<<<...<<<.<<<<<..<<<<<<<.<<.....<<.
.......>>..........<<<<<<<.......<<.<<<..<<<<<<...
....<<..<<<<<.....>>>.......>>..>>.....<<<....>>>.
........>>>...>>>>>>>>....>>>>>>>..>>..>>>>>>>....
...<<.....>>...<....<<<<<<.......>>>>>>....>.....>
>>>>.....<<<<<<<.........>>>>>>>.....>>>...>>>>>>>
>>>.>>........<.....<<<<<<...<<<<...........<.....
..>.............>>>>..>>>>>>....>..........<<<<<<<
<<....>>>>>>>>>........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6nu3 Structural insights into unique features of the human mitochondrial ribosome recycling.
• Resolution: 4.4 Å
• Binding residue (original residue number in PDB): F117 E118 R120 L216 D217 R276 K277 Q301 I306 G335 R337 S338 A339 R375 V376 R377 E378 R379 K380 K381 P382 Q384 E385 A387 R388 R389 T392 W393 K395 R396
• Binding residue (residue number reindexed from 1): F47 E48 R50 L125 D126 R185 K186 Q210 I215 G244 R246 S247 A248 R284 V285 R286 E287 R288 K289 K290 P291 Q293 E294 A296 R297 R298 T301 W302 K304 R305

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005730 nucleolus
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005763 mitochondrial small ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6nu3, PDBe:6nu3, PDBj:6nu3
• PDBsum: 6nu3
• PubMed: 30962385
• UniProt: P82933|RT09_HUMAN Small ribosomal subunit protein uS9m (Gene Name=MRPS9)