Structure of PDB 6yxx Chain AF Binding Site BS01

Receptor Information
>6yxx Chain AF (length=419) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSIFSPRYDWRTSGVHDIAPRDEGDFLYQGPQHVLPGAHPLPLHHPHNTI
TRPVISPYIPSPQRSHPYFTAPLPELPHFSTTKPIVYTYGTMKERIIAPV
FNLKNEVIYTRELDPFIFGMYPEVEELSKNLTYWMVRCQNFASKWDYETR
EIWRYTWGGRTKPSKPWNMLMPTMDVKTWSKSNRMMLTLKMLQGRLQVVD
RLTLEEPTQECYLELCRNMSWDVRHTGGGVLFMDGGSRITPSSEFDRAFF
FGSFFNGRNKIVRPTVLCDEQYDYNKTAAKQRMKGPKGAKNPIPINRFNA
YDAMKHDRLVITEGALMQLEDELYEHKLQILPPHIRNQLPEYGYLDSEAL
GDCVPSLKTIQMEAAARTEEAESDMYKSFIDNPYNPWKDNMDASYAVDGA
DGTVQKFVDGKKVSWSMLS
Ligand information
>6yxx Chain AA (length=904) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB6yxx Structural Insights into the Mechanism of Mitoribosomal Large Subunit Biogenesis.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		S18 F21 R24 W27 R28 R38 H61 H64 E140 E142 E143 M152 A159 S160 W162 Y164 E165 T166 R167 T196 R200 T201 K202 K217 K221 R224 T266 Y314 K316 A319 K320 R322 K327 K345 I370
Binding residue
(residue number reindexed from 1)		S1 F4 R7 W10 R11 R21 H44 H47 E123 E125 E126 M135 A142 S143 W145 Y147 E148 T149 R150 T156 R160 T161 K162 K177 K181 R184 T226 Y274 K276 A279 K280 R282 K287 K305 I330
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6yxx, PDBe:6yxx, PDBj:6yxx
PDBsum6yxx
PubMed32679035
UniProtA0A1G4HYD1

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