Structure of PDB 6r6g Chain AE Binding Site BS01

Receptor Information

>6r6g Chain AE (length=76) Species: 9615 (Canis lupus familiaris)

VLLESEQFLTELTRLFQKCRTSGSVYITLKKYDGNKCLLRATDGKKKIST
VVSSKEVNKFQMAYSNLLRANMDGLK

Ligand information

>6r6g Chain K (length=1698)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
cccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggu
agucgccgugccuaccauggugaccacgggugacggggaaucaggguucg
auuccggagagggagccugagaaacggcuaccacauccaaggaaggcagc
aggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaaua
acaauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaa
auccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcg
guaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcu
cguaguuggaucuugggagcggccguccccugcucggcgccggcccgaag
cguuuacuuugaaaaaauuagaguguucaaagcaggccgccuggauaccg
cagcuaggaauaauggaauaggaccgcgguucuauuuuguugguuuucgg
aacugaggccaugauuaagagggacggccgggggcauucguauugcgccg
cuagaggugaaauucuuggaccggcgcaagacggaccagagcgaaagcau
uugccaagaauguuuucauuaaucaagaacgaaagucggagguucgaaga
cgaucagauaccgucguaguuccgaccauaaacgaugccgacuggcgaug
cggcggcguuauucccaugacccgccgggcagcuuccgggaaaccaaagu
cuuuggguuccggggggaguaugguugcaaagcugaaacuuaaaggaauu
gacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaac
acgggaaaccucacccggcccggacacggacaggauugacagauugauag
cucuuucucgauuccgugggugguggugcauggccguucuuaguuggugg
agcgauuugucugguuaauuccgauaacgaacgagacucuggcaugcuaa
cuaguuacgcgaccccggucggcguaacuucuuagagggacaaguggcgu
ucagccacccgagauugagcaauaacaggucugugaugcccuuagauguc
cggggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuac
gccggcaggcgcggguaacccguugaaccccauucgugauggggaucggg
gauugcaauuauuccccaugaacgaggaauucccaguaagugcgggucau
aagcuugcguugauuaagucccugcccuuuguacacaccgcccgucgcua
cuaccgauuggaugguuuagugaggcccucggaucggccccgccggggug
cccuggcggagcgcugagaagacggucgaacuugacuaucuagaggaagu
aaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<..........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<<.>>>>>>>>..>.>>>...>>..>.>>>.<<<....<<<....<<<<<
<<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>.
...>>>.>>.<<.<<<..........>>>.>>.<.<<<..>>>.>...>>
>>>>.........<<<....<<<<...>>>>..>>>..>...>>.>....
.<<<<<<<<<.<<<....>>>..>>>>>>.>>>......<<..<......
.....>..>>.........<<<<<((......<<<<.....<<..))>>.
......>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<
<...<<<.<<....<<<.<<<..>>>.>>><<<<<<<.<<..>>>>>>.>
>>.<<<<<<.<.......<<...<.......>.<<<<.>>>>...>>...
...>.>>>..>>>........<.<<.<<<<<<<...............>>
>>>>>.>>.>....>>....<<<<<<..<...<<<<..<<<.<<<<<<<<
...<<<......>>>......>>>>>>>.>>>>.......<<....>>..
.>>>>..>..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<
<<.<.....>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.
<<<<<<.<<<<......>>>>>>>>>>.>..>>>...<<..))>>...>>
.....>>>.>.>.<<<......<<<<....>>>>....>>>..)))).]<
<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<<<......<<.......
.>>..........<<<<<.<....<<<<<........<<.<<<.......
.>>>.>>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<
<....>>>...<<<......>>>...>>.>>>....<<<...<...<<<<
..<<<<<<<<<<<<..>>>>.>>>>>>>>..>>>>..>.....<<<<<..
...>>>>>........>>>....>>>.>>>.....>>>>>>>.....>.>
>>>>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<
<<<....>>>>.>>>....>.........>>>.>>......<.....<<<
<<..........>>>>>.....>.....>>>>>.....<<<<<<<<....
...>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<
<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<<..
>>>>>>>>>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>
>...>.>>...>.....<<<<<<<<<<..>>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6r6g Structural and mutational analysis of the ribosome-arresting human XBP1u.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): N77 K78 M81 K95
• Binding residue (residue number reindexed from 1): N58 K59 M62 K76

Gene Ontology

Molecular Function

• GO:0008312 7S RNA binding
• GO:0030942 endoplasmic reticulum signal peptide binding

Biological Process

• GO:0006614 SRP-dependent cotranslational protein targeting to membrane

Cellular Component

• GO:0005786 signal recognition particle, endoplasmic reticulum targeting
• GO:0048500 signal recognition particle

External links

• PDB: RCSB:6r6g, PDBe:6r6g, PDBj:6r6g
• PDBsum: 6r6g
• PubMed: 31246176
• UniProt: P16255|SRP14_CANLF Signal recognition particle 14 kDa protein (Gene Name=SRP14)