Structure of PDB 6olz Chain AE Binding Site BS01

Receptor Information

>6olz Chain AE (length=226) Species: 9606 (Homo sapiens)

PHCSRNPVLVRGIGRYSRSAMYSRKAMYKRKYPVGGDKNGGTRVVKLRKM
PRYYPTEDVPRKLLSHGKKPFSQHVRKLRASITPGTILIILTGRHRGKRV
VFLKQLASGLLLVTGPLVLNRVPLRRTHQKFVIATSTKIDISNVKIPKHL
TDAYFKKKKLRKPRHQEGEIFDTEKEKYEITEQRKIDQKAVDSQILPKIK
AIPQLQGYLRSVFALTNGIYPHKLVF

Ligand information

>6olz Chain A2 (length=3643)

cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccccgcggggcgcgggacaugug
gcguacggaagacccgcuccccggcgccgcucguggggggcccaaguccu
ucugaucgaggcccagcccguggacggugugaggccgguagcggcccccg
gcgcgcgcccgggucuucccggagucggguugcuugggaaugcagcccaa
agcgggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauag
ucaacaaguaccguaagggaaaguugaaaagaacuuugaagagagaguuc
aagagggcgugaaaccguuaagagguaaacgggugggguccgcgcagucc
gcccggaggauucaacccggcggcggguccggccgugucggcggcccggc
ggaucuuucccgcccccggggucggcgggggaccgucccccggaccggcg
accggccgccgccgggcgcauuuccaggcggugcgccgcgaccggcuccg
ggacggcugggaaggcccggcggggaagguggcucggggcccccgagugu
uacagcccccccggcagcagcacucgccgaaucccggggccgagggaagc
gagacgucgccgcgcucuccccccugggggggccgggccaccccucccac
ggcgcgaccgcucucccagggggcggggcggacuguccccagugcgcccc
gggcgggucgcgccgucgggcccggggggccacgcgcgcgucccgggacg
gcggagcgagcgcacggggucggcggcgacgucggcuacccacccgaccc
gucuugaaacacggaccaaggagucuaacacgugcgcgagucgggggcuc
gcacgaaagccgccguggcgcaaugaaggugaaggccggcgcgcucgccg
gccgaggugggaucccgaggccucuccaguccgccgaggggcaccaccgg
cccgucucgcccgccgcgccggggagguggagcacgagcgcacguguuag
gacccgaaagauggugaacuaugccugggcagggcgaagccagaggaaac
ucugguggagguccguagcgguccugacgugcaaaucggucguccgaccu
ggguauaggggcgaaagacuaaucgaaccaucuaguagcugguucccucc
gaaguuucccucaggauagcuggcgcucucgcccacgcaguuuuauccgg
uaaagcgaaugauuagaggucuuggggccgaaacgaucucaaccuauucu
caaacuuuaaauggguaagaagcccggcucgcuggcguggagccggggug
gaaugcgagugccuagugggccacuuuugguaagcagaacuggcgcugcg
ggaugaaccgaacgccggguuaaggcgcccgaugccgacgcucaucagac
cccagaaaagguguugguugauauagacagcaggacgguggccauggaag
ucggaauccgcuaaggaguguguaacaacucaccugccgaaucaacuagc
ccugaaaauggauggcgcuggagcgucgggcccauacccggccgucgccg
gcgucgagaguggacgggagcggcggcccgcccgcggacgcuacgccgcg
acgaguaggagggccgcugcggugagccuugaagccuagggcgcgggccc
ggguggagccgccgcaggugcagaucuuggugguaguagcaaauauucaa
acgagaacuuugaaggccgaaguggagaaggguuccaugugaacagcagu
ugaacaugggucagucgguccugagagaugggcgagcgccguuccgaagg
gacgggcgauggccuccguugcccucggccgaucgaaagggagucggguu
cagauccccgaauccggaguggcggagaugggcgccgcgaggcguccagu
gcgguaacgcgaccgaucccggagaagccggcgggagccccggggagagu
ucucuuuucuuugugaagggcagggcgcccuggaauggguucgccccgag
agaggggcccgugccuuggaaagcgucgcgguuccggcggcguccgguga
gcucucgcuggcccuugaaaauccgggggagaggguguaaaucucgcgcc
gggccguacccauauccgcagcaggucuccaaggugaacagccucuggca
uguuggaacaauguagguaagggaagucggcaagccggauccguaacuuc
gggauaaggauuggcucuaagggcuggcagccgacuuagaacuggugcgg
accaggggaauccgacuguuuaauuaaaacaaagcaucgcgaaggcccgc
ggcggguguugacgcgaugugauuucugcccagugcucugaaugucaaag
ugaagaaauucaaugaagcgcggguaaacggcgggaguaacuaugacucu
cuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaaugg
augaacgagauucccacugucccuaccuacuauccagcgaaaccacagcc
aagggaacgggcuuggcggaaucagcggggaaagaagacccuguugagcu
ugacucuagucuggcacggugaagagacaugauagaauaagugggaggcc
cgggccgccggugaaauaccacuacucugaucguuuuuucacugacccgg
ugaggcgggggggcgagcccgaggggcucucgcuucuggcgccaagcgcc
cgcccggccgggcgcgacccgcuccggggacagugccagguggggaguuu
gacuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgag
cucagggaggacagaaaccucccguggagcagaagggcaaaagcucgcuu
gaucuugauuuucaguacgaauacagaccgugaaagcggggccucacgau
ccuucugaccuuuuggguuuuaagcaggaggugucagaaaaguuaccaca
gggauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuug
auccuucgaugucggcucuuccuaucauugugaagcagaauucgccaagc
guuggauuguucacccacuaauagggaacgugagcuggguuuagaccguc
gugagacagguuaguuuuacccuacugaugauguguuguugccaugguaa
uccugcucaguacgagaggaaccgcagguucagacauuugguguaugugc
uuggcugaggagccaauggggcgaagcuaccaucugugggauuaugacug
aacgccucuaagucagaaucccgcccaggcggaacgauacggcagcgccg
cggagccucgguuggccucggauagccgguccgggguccggugcggagug
cccuucguccugggaaacggggcgcggccggaaaggcggccgcccccucg
cccgucacgcaccgcacguucguggggaaccuggcgcuaaaccauucgua
gacgaccugcuucugggucgggguuucguacguagcagagcagcucccuc
gcugcgaucuauugaaagucagcccucgacacaaggguuuguc

.........................<<<<<<<....<......>.....>
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>..>...<.<<..<<.....<....<...<....<<<<........<.<.
.......>.>..................................>>>>.>
.>....>....>>..>>.>.......<<<<<<<........>>>>>>>..
...(((((..<<<<<<)))))..]]]........................
..........<<....>>...............<<<......>>>.....
.............................<<<<<<<<..<<<........
..<<.<.<<<<......<<..<.<<.........<<...<<.<....<<<
<<.<<<..<<<<<<<<<.>>>..>>>>>>>>>>>>>>>>>...>>.....
.....>.>>..>.>.....>>>>.>.>>.....<<<<<<<..<<<<<<<<
<..<<<........<<.<<<.<<.<......<<<<<<<...>>>>>>>..
......>>>.>>>>>...........>>>....>>>>>>>>>........
...........<<<....<<<<<<..>>>>>>....<<<.<<<..<<...
<.<..<.<<<<<...<<...>>.<<<<<<<.<<<<....>>>>.>>>>>>
>>>>>>.>...>>....>>....>>>.>>>........<<<<<.>.>>>>
..........>>>.......>>.>>>>>....>>>...>>>>>>>>..<<
<<........>>>><<<<<<....<<<<<<<<<<<<<..<<<...<<<<.
.......>>>>.....>>>...<<....>>...<<<<<<<......>>>>
>>>..<<<<<..<<<...<.....[[...[...>...>>>...>>>>>.<
<<<<<<<<.<<<<......>>>>>>>>>>>.>>....>>>>>>>>>>>>>
..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>
>>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>
>>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<
....<.<<<....>>>(><<.<<<<<<<........<<<.<<<<<<<<<.
..<<<....<<<....<<<...<<<<<.........>>>>>.>>>....>
>>..>.>>...>>>>>>>....<<<<<<<<.........>>>>>>>>...
.>>>>>>>>>>>>..>>).<<<<.<<<<<.....>>>>>.>>>>....<<
<......>>>...<<<<<<<...<<<(((.......<<<<<.....<<..
........<<<.<<<<<<<<<<.......<<<<<.<<.............
........>>.........<........>...>>>>>...>>>>>>>>>>
>>>..........))).>>...>>>>>..>>>...>>>>>>><<<<<<.<
............]...]]...........................>.>>>
>>>....>>>>>>.<<<<<<<<<<.<<......<<<<.<<<<....>>>>
>>>>...>>>>>>>>>>.>>.....>>>>>><<.....<<.....<<<<<
<.......>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....
>>.>>>>>>....((<<<<<<...<<....<<<....>>>..........
<<.<<<<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<..
......>>>>>))<<<<....<<<<<..<<<<<<<<....>>>>>>>>..
<<<....>>>...<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<.
.{{{..>>>>>>....<<<<<.<<<<.<<<<.....<<<.....>>>...
..>>>>>>>>..>>>>>.....<<<<<<<.......>>>>>>>>>>>...
>>>>>>>>>>>>.........>>>>>>>..>..........>>.>>>.>>
>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>.
...<<<<.....<<<<<<<.<<...............<<<<<........
.......>>>>><<.<<<<<<<<<<<.>>>>>..>>>>>>.>>.......
.....<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<..
...>>>>......>>>>>>>...<<..<<<..<<<<<<.<..<<<....<
<<<<....>>>>.>...>>>>>>>>..>>>>><<<<<<.......>>>>>
>........<...........<<<<<.......>>>>>.....>.....>
>....>>.>>>>>>>.....>>.>>>>>>>..>>>>>>....>>....<<
<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[[[
..<<<<<.<<<<<<<<<.<<<<<<<<<.<<.........<<<<<..<<<<
..>>>>............>>>>>......>>..>>>>>>>>>...<<<<<
.....<<<<........<<<...>>>...................<<<<<
<<......>>>>>>>..>>>>..>>>>>....>>>>>>>>>..>>>>>..
.<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<
<...<<<<<<.......>>>>>>.....<<...(((>>....>>>>>>>.
..<<<.<<<<<.......>>>>.>>>>.<<<....>>>.>>)))......
.((((((..(((..>>>>>>.)))))))))..........]]]]..}}]]
]].......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>
.>.>........<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.
>.<<<.........>>>.....>>>>>..>...>>>.>.....<<<<<<<
....>>>.>>>>....}}..}}}.]]]]].....<<<<<<.<..<<<..<
.<<<<<.................>>>>>.><<<<....<<<<....<<.<
<<<<<.}}}..>>>>..>>.>>...>>>>...>>>><<<<<...<<<<<.
..........>>>>>...>>>>>.>>>...>.>>>>>>.....<<<<<<<
.<<..<<<...................<.<<<>>>.>.............
.....<<<..<<<<.....<<<.<<<<<<<......>>>>>>>>>>....
>>>>..>>>..............>>>...>>>>>>>>><<<<<.<.....
........>.....<.<<<<<<<.<<.....<<<<.<..<<<<<......
>>>>>..>>>>>....>>....>>>>.>>>.>...>>>>>...

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6olz Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): P42 H43 C44 S45 R46 R52 S58 R59 S60 Y63 S64 R65 K66 A67 Y69 K70 R71 K72 Y73 P95 K100 G102 R105 K108 R110 K111 P113 R114 Y115 R123 K124 L125 L126 H128 K130 P132 F133 S134 H136 V137 T154 R156 R158 L172 L179 V180 L181 R183 P185 R187 R188 H190 F217 K219 R226 H227 Q228 E229 F233 E236 K239 Y240 R246 K247 Q250 K262 P265 Q266 R272 S273 V274 T278 N279
• Binding residue (residue number reindexed from 1): P1 H2 C3 S4 R5 R11 S17 R18 S19 Y22 S23 R24 K25 A26 Y28 K29 R30 K31 Y32 P33 K38 G40 R43 K46 R48 K49 P51 R52 Y53 R61 K62 L63 L64 H66 K68 P70 F71 S72 H74 V75 T92 R94 R96 L110 L117 V118 L119 R121 P123 R125 R126 H128 F155 K157 R164 H165 Q166 E167 F171 E174 K177 Y178 R184 K185 Q188 K200 P203 Q204 R210 S211 V212 T216 N217

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6olz, PDBe:6olz, PDBj:6olz
• PDBsum: 6olz
• PubMed: 31160784
• UniProt: Q02878|RL6_HUMAN Large ribosomal subunit protein eL6 (Gene Name=RPL6)