Structure of PDB 4v6i Chain AE Binding Site BS01

Receptor Information
>4v6i Chain AE (length=254) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSAPEAQQQKRGGFGGRNRGRPNRRGPRNTEEKGWVPVTKLGRLVKAGKI
TTIEEIFLHSLPVKEFQIIDTLLPGLQDEVMNIKPVQKQTRAGQRTRFKA
VVVVGDSNGHVGLGIKTAKEVAGAIRAGIIIAKLSVIPIRRGYWGTNLGQ
PHSLATKTTGKCGSVTVRLIPAPRGSGIVASPAVKKLLQLAGVEDVYTQS
NGKTRTLENTLKAAFVAIGNTYGFLTPNLWAEQPLPVSPLDIYSDEASAQ
KKRF
Ligand information
>4v6i Chain CA (length=1721) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaaguuaagcca
ugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucau
uaaaucaguuaucguuuauuugauagacauggauaacugugguaauucua
gagcuaauacauguuaaaaucucgacccuuuggaagagauguauuuauua
gauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuuc
gaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuau
caacuuuaugguaggauaguggccuaccaugguuucaacggguaacgggg
aauaaggguucgauuccggagagggagccugagaaacggcuaccacaucc
aaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguag
ugacaauaaauaacgauacagggcccauucgggucuuguaauuggaauga
guacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugc
cagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugca
guuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuu
uucguguacuggauuuccaacgggguccuucuggcuaaccuugaguccuu
guggcucuuggcgaaccaguguucaaagcaggcguauugcucgaauauac
guuugguucuauuuuguugguuucuaggaccaucguaauggggacggucg
ggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaag
acuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaac
gaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccaua
aacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggc
accuuagagaaaucaaagucuuuggguucuggggggaguauggucgcaag
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacggggaaacucaccagguccagacacaaua
aggauugacagauugagagcucuuucuugauuuugugggugguggugcau
ggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaa
cgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccac
uucuuagagggacuaucgguuucaagccgauggaaguugaggcaauaaca
ggucugugaugcccuuaacguucugggcgcacgcgcgcuacacugacgga
gccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuc
cgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauu
ccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuug
uacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucag
gaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggac
aaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggu
gaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<<..<<<<<...<...........<<<.
<<<...<...<<.....<............>....>>>.......<<...
.....<<<..<<..<<...........<<<<.....<<.<<<.....>>>
.>>......>>>>.<.<<<.........>>>.>....<.<<<<[......
((...((..<..<.....>..>.............>.]..>>>.>.....
<..<<<<.<<<<.....>>>>>>>>>.........>>>>..>>>.<<<..
..<<<..<<<<<<<.........>>>>>>>>>>......>>>...<<<<<
<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<.
...>>.>...>>>>>>.......<.<<<...<<<<.....>>>.>>>>>.
.......>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......
..............................<<<<<((......<<<<...
..<<..))>>.......>>>>.>>>>>..>>>>>.>>>>.........<<
<[[.....<.<<...<<<..............<..<.....<..<..<..
...>..>...>..>...>.......<...<.<<.<.<...<<..<....>
..>>...>.>.>>.>...>.<<.....<..<......>..>.....>>.<
...<<<<<<<<.....))...)).>>>>>>>>..>......<<<<<.<<.
..<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.
>>>......<<<....>>>..>>>>..>>.>>>.>>....>>>...>>.>
....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>....
......<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>.
.>>>..<<.].]>>...>>.....>>>.>>>.<<<......<<<......
>>>....>>>..)))).]<<<<<.<<<<<<<...<..<<<<<..<<<.<<
<<<<......<..........>..........<<<<<........<<..<
<<....<<............>>........>>>..>>...<..<<<..<<
.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>
>......<<..<<<.<<<<..<<<<..<<<<<......>>>>>....>>>
>..>>>>>>>.....<<<<.......>>>>........>>......>>>.
>>>.....>>>>>.>......>>>>>..>>.>>>>.>>>.....<<<<<.
........<..........<<<....>>>..........>.........>
>>>>...........<<<<<<..........>>>>>>..........>>>
>>.....<<<<<<<<<.....>>>>>>>>>......>....>>>>>>>>>
>.>>.......<<.<..<<...<<....<<<<<<<<.<<<..<.<<....
..<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>......>>.>
..>>>.>>>>>>>>...>>...>>...>.>>.........<<<<<<<<<.
...>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v6i Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
Resolution8.8 Å
Binding residue
(original residue number in PDB)		E120 V121 A122 G123 I125 R126 A127 K133 Q150 T159 V184 K186 L188 Q189 Y197 T198 Q199 N201 G202 K203 A217 N220 Y222 F224 L225 N228
Binding residue
(residue number reindexed from 1)		E120 V121 A122 G123 I125 R126 A127 K133 Q150 T159 V184 K186 L188 Q189 Y197 T198 Q199 N201 G202 K203 A217 N220 Y222 F224 L225 N228
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0070181 small ribosomal subunit rRNA binding
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0042254 ribosome biogenesis
GO:0045903 positive regulation of translational fidelity
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:0032040 small-subunit processome
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v6i, PDBe:4v6i, PDBj:4v6i
PDBsum4v6i
PubMed20980660
UniProtP25443|RS2_YEAST Small ribosomal subunit protein uS5 (Gene Name=RPS2)

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