Structure of PDB 8ove Chain AD Binding Site BS01

Receptor Information
>8ove Chain AD (length=87) Species: 5702 (Trypanosoma brucei brucei) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPKSSRDDVYRFFFTEGVVSCKKDPLGTWKGTLGGKTFKLPTLQVMQLMR
SLKSRGLIKEQFAWRHFYWTLNDEGINYMRKYLYLGA
Ligand information
>8ove Chain AA (length=1836) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaucugguugauucugccaguagucauaugcuuguuucaaggacuuagcc
augcaugccucagaaucacugcgcaggaaucugcgcauggcucauuacau
cagacguaaucugccgccaaaauuuugcgcauuacuggauaacuuggcga
aacgccaagcuaauacaugaaccaaucggacgcucucuuugggacgucca
gcgaaugaaugaaaccaacgccuccggaggcaguaacacucagacguguu
gacucaauucauuccgugcgaaagccgagcugcucggcgucuacugacga
acaacugcccuaucagccagugauggccguguaguggacugccauggcgu
ugacgggagcgggggauuaggguucgauuccggagagggagccugagaaa
uagcuaccacuucuacggagggcagcaggcgcgcaaauugcccaaugucg
aaaaaauacgaugaggcagcgaaaagaaauagagccgaccgugugguugu
uuucaaugggggauacucaaacccauucaauaucgaguaacaauuggagg
acaagucuggugccagcacccgcgguaauuccagcuccaaaagcguauau
uaaugcuguugcuguuaaaggguucguaguugaacugugggccacguagu
guggugccguaccagucccguaccucgacguguuuugacccacgcccucg
uggcccagauacagaaacacgggagcaguucgcaugucaugcaugggcgu
ccgugaauuuuacugugaccaaaaagaugcgaccaaagcaguuugccgac
uugaauuacaaagcaugggauaacgaagcaucagcccugggguuauguug
guuuuagaaguccuugggagauuauggggccgccgcgcggcuucgaauga
aggaggguaguucgggggagaacguacuggugcgucagaggugaaauucu
uagaccgcaccaagacgaacuacagcgaaggcauucuucaaggauaccuu
ccucaaucaagaaccaaaguguggggaucaaagaugauuagagaccauug
uaguccacacugcaaaccaugacacccaugaauuggggagugccucucag
cacguuucuuacuucuucacgcgaaagcuuggagguuacagucucagggg
ggaguacguucgcaagagugaaacuuaaagaaauugacggaauggcacca
caagacguggagcgugcgguuuaauuugacucaacacggggaacuuuacc
agauccggacagggugaggauugacagauggaguucuuucucgauccccu
gaaugguggugcauggccgcuuuuggucgguggagugauuuguuugguug
auuccgucaacggacgagauccaagcugcccaguaggugccgggauuguc
cacacaggacagcauccuucuuuaggccccuucucugcgggauuccuugc
uuuucgcgcaaggugagauuuugggcaacagcaggucugugaugcuccuc
aauguucugggcgacacgcgcacuacaaugucagugagaacaagagucga
cgcucccgcuugaucaaaagagcggggaaaccacggaaucacguagaccc
acuugggaccgaguauugcaauuauuggucgcgcaacgaggaaugucucg
uaggcgcagcucaucaaacugugccgauuacgucccugccauuuguacac
accgcccgucguuguuuccgaugauggugcaauacaggugaucggaccgu
caccgaaaguucaccgauauugcuucaauagaggaagcaaaagucguaac
aagguagcuguaggugaaccugcagcuggaucauuu
...<<<<<.{.[[[[>>>>><<<<.<<<<<<...<<<...<......<<<
.<<<..<<....<<....<<<..>>>...>>.>>......<<........
<<<..<<..<<...<<..<................<<.....<<<<<<..
...>>>>>>......>>..........<<<<<.<<<.....>>>>>>>>.
<<<<<<<<<<....(((((<<<<....>>>>...................
......>>>>>>>>...>>....<<<<<<<.>>>>>>>...>..>>..>>
>>..>>>.<<<....<<<....<<<<<.<<.......>>.>>>>>>>>..
....>>>..<<<.<<<<....>>>>....>>>.>>.<<.<<<........
..>>>.>>.<<<<<..>>>>>...>>>>>>.........<<<....<<<.
.........>>>..>>>..>....>>>....<<<................
.>>>.......<..............>................<<<<<((
....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>>>>
>>.........<<<[[.....<<<<...<<<.......<<<<...<...<
..<<....<<..<.<.........>.>..>>..>>.>...>..>>>>...
................<<.........<<....<<.......>>..>>..
..>>....<<..<...........<...<<.......>><<<<....>>>
>....>............>..>>...........<<..<<<.<<<.))))
)..>.>>...>>>..>>........<<..<.<.....>>...>>......
....<<<<<..<<...<<<<<<<<..<<<<<<<<...<<<......>>>.
.....>>>>>>>.>.>>.......<<....>>.>>>>>>...>>>>>.>>
....>>>...>>>>...<<<<<<<<...<...<<<<.<.....>.>>>>.
..>>>>>>>>>.........<<<.<<...<..<.<<<<<<<<<......>
>>>.>>>>>.>..>......<<..]]>>.....>>.....>>>.>>>.<<
<......<<<<....>>>>....>>>..]]]].}<<<<<.<<<<<<<..<
<.<<<<<<..<<.<<<<<<<......<<........>>..........<<
<<<.<....<<<<<........<<.<<<......>>>.>>......>>>>
>...<<.<<<..<<.<<<<<<....<<<.<<<<<....>>>...<<<...
...>>>...>>.>>>....<<<<<.<<<<.....<<<.<<<<<<<.....
..................>>>>..>>>.>>>.....>>>>....<<<<<<
.......>>>>>>.......>>>>>....>>>.>>>.....>>>>>>>..
...>.>>>>>...>>.>>>>>.>>.....<<<.<<<.......<....<.
..>.<<<<<<<........>>>>>>>....>........>>>...>>>..
....<....<<<.<<..........>>.>>>.....>.....>>>>>>..
..<<<<<<<.........>>>>>>>......>>...>>>>>>>>>>.>>.
...<..<<.<.<<<<<<<<..<<.<<<.<<<<<<..<<<<<.<...<...
....>...>.>>>>>..>>>>>>.>>>.>>..>>>>>>>>..>.>>...>
.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ove A single pseudouridine on rRNA regulates ribosome structure and function in the mammalian parasite Trypanosoma brucei.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K27 L47 R54 S55 S58 F66 F71
Binding residue
(residue number reindexed from 1)		K23 L43 R50 S51 S54 F62 F67
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ove, PDBe:8ove, PDBj:8ove
PDBsum8ove
PubMed37985661
UniProtQ38B66

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