Structure of PDB 8oeq Chain AD Binding Site BS01

Receptor Information
>8oeq Chain AD (length=96) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NINSKLALTIKSGKYTLGYKSVVKSLRTGKAKLVIIAANTPVLRKSELEY
YAMLSKTPVYYFQGGNNELGTVCGKLFRVGTLSILDAGDSDILSSI
Ligand information
>8oeq Chain 1 (length=3217) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcg
gaggaauguggcacggcuucugcuguguguuauagccucugacgauacug
ccagccuagaccgaggacugcgguuuaccuaggauguuggcauaaugauc
uuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcga
guguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggg
gcccauuagggugcaccaucgaccgauccugauguguucggauggauuug
aguaagagcauagcuguugggacccgaaagauggugaacuaugccugaau
agggugaagccagaggaaacucugguggaggcucguagcgguucugacgu
gcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaacca
ucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucgu
aucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaug
accuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuua
auugaacguggacaauugaaugaagagcuuuuagugggccauuuuuggua
agcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccgga
augcacgcucaucagacaccacaaaagguguuaguucaucuagacagccg
gacgguggccauggaagucggaauccgcuaaggaguguguaacaacucac
cggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuu
auacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcgug
gaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuag
ugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacu
gaaguggggaaagguuccaugucaacagcaguuggacauggguuagucga
uccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggcca
accaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucu
ucacggcaacguaacugaauguggagacgucggcgugagcccugggagga
guuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccgga
gauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugc
gcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaa
gucguacucauaaccgcagcaggucuccaagguuaacagccucuaguuga
uagaauaauguagauaagggaagucggcaaaauagauccguaacuucggg
auaaggauuggcucuaaggaucgguuuaacgaucaacuuagaacugguac
ggacaaggggaaucugacugucuaauuaaaacauagcauugugaugguca
gaaagugauguugacacaaugugauuucugcccagugcucugaaugucaa
agugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacu
cucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaau
ggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacag
ccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugag
cuugacucuaguuugacauugugaaaagacauggaggguguagaauaagu
gggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuu
auucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcc
cucugggcgauccggguugaagacauugucagguggggaguuuggcuggg
gcggcacaucuguuaaacgauaacgcagguguccuaagggggacucaugg
agaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuug
auuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuag
ucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaa
cuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuuc
gaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggau
uguucacccacuaauagggaacgugagcuggguuuagaccgucgugagac
agguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuu
aguacgagaggaaccguucauucagauaauugguuuuugcggcugucuga
ucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccuc
uaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuua
gauggauacgaauaagacuuuagucgcuggaccauagcaggcuggcaacg
gugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaauguca
acaugcgcggggauaaauccuuugcauacgacuuagauguacaacggagu
auuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcu
cuuguugucugauuugu
.......................<<<<<<.....<......>......>>
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>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.........
....<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>
>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]....}..........................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<.<.<...
......>>.>.>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<
<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>
>>.>>>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>
>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..
<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..
<<<<....>>>>...>>>>>.<<<<<<<<<..<<....>>>..>>>.>>>
.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<.
.<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<...
.....>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>
>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<..
.<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>
>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<...
...>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<...
..>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...
..<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<
<.<<<...<<.........>>...>>>.........<<......>>...>
>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>
..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.<<
<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>.
.>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<
.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<
<<<...<<....<<<....>>>..........<<<<<<....>>>>>>..
....>>....>>>..<<<<<........>>>>>))<<<<.<<<<<<<...
..<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<
<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>..
..>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...
>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>
.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..
<<<<.....<<<<<<<.<<.........<.....<<<<<...........
....>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>.....
.......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<
.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<...
..<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>
>>>........<...........<<<<<.......>>>>>.....>....
.>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....
<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[
[[..<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<.............
...............................>>.>...>>>>>>>>>>..
.<<<<<.....<<<<..<<<<<......>>>>>..............<<<
<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<...
..>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<
<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<
<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((
..((((.>>>>>>))))))))))..........]]]]..}}]]]].....
..<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>...
....<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<..
.......>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>
.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<..
...............>>>>>..<<<<<...<<<<....<<<<<<<<<<}}
}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<.........
..>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<....
...<<..........<<<<..>>>>......>>.......<<<<<<...<
<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............
..>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.
<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>
>>.>>>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.3 Å
Binding residue
(original residue number in PDB)
L27 G28 K30 S31 N49 P51 V52 L53 R54 K55 S56 E59 N76 L86 F87 R88 V89 G90
Binding residue
(residue number reindexed from 1)
L17 G18 K20 S21 N39 P41 V42 L43 R44 K45 S46 E49 N66 L76 F77 R78 V79 G80
External links
PDB RCSB:8oeq, PDBe:8oeq, PDBj:8oeq
PDBsum8oeq
PubMed
UniProtA0A1D8PM75|RL30_CANAL Large ribosomal subunit protein eL30 (Gene Name=RPL30)

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