Structure of PDB 7qi4 Chain AD Binding Site BS01

Receptor Information
>7qi4 Chain AD (length=343) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFFTKLTADELWKGALAETGAGAKKGRGKRTKKKKRKDLNRGQIIGEGRY
GFLWPGLNVPLMKNGAVQTIAQRSKEEQEKVEADMIQQREEWDRKKKMKV
KRERGWSGNSWGGISLGPPDPGPCGETYEDFDTRILEVRNVFTMTAKEGR
KKSIRVLVAVGNGKGAAGFSIGKATDRMDAFRKAKNRAVHHLHYIERYED
HTIFHDISLRFKRTHIKMKKQPKGYGLRCHRAIITICRLIGIKDMYAKVS
GSINMLSLTQGLFRGLSRQETHQQLADKKGLHVVEIREECGPLPIVVASP
RGPLRKDPEPEDEVPDVKLDWEDVKTAQGMKRSVWSNLKRAAT
Ligand information
>7qi4 Chain AA (length=954) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
auagguuugguccuagccuuucuauuagcucuuaguaagauuacacaugc
aagcauccccguuccagugaguucacccucuaaaucaccacgaucaaaag
ggacaagcaucaagcacgcagcaaugcagcucaaaacgcuuagccuagcc
acacccccacgggaaacagcagugauuaaccuuuagcaauaaacgaaagu
uuaacuaagcuauacuaaccccaggguuggucaauuucgugccagccacc
gcggucacacgauuaacccaagucaauagaagccggcguaaagaguguuu
uagaucacccccuccccaauaaagcuaaaacucaccugaguuguaaaaaa
cuccaguugacacaaaauagacuacgaaaguggcuuuaacauaucugaac
acacaauagcuaagacccaaacugggauuagauaccccacuaugcuuagc
ccuaaaccucaacaguuaaaucaacaaaacugcucgccagaacacuacga
gccacagcuuaaaacucaaaggaccuggcggugcuucauaucccucuaga
ggagccuguucuguaaucgauaaaccccgaucaaccucaccaccucuugc
ucagccuauauaccgccaucuucagcaaacccugaugaaggcuacaaagu
aagcgcaaguacccacguaaagacguuaggucaagguguagcccaugagg
uggcaagaaaugggcuacauuuucuaccccagaaaacuacgauagcccuu
augaaacuuaagggucgaagguggauuuagcaguaaacugagaguagagu
gcuuaguugaacagggcccugaagcgcguacacaccgcccgucacccucc
ucaaguauacuucaaaggacauuuaacuaaaaccccuacgcauuuauaua
gaggagacaagucguaacaugguaaguguacuggaaagugcacuuggacg
aacc
..((((..<<<<<<.)))).<<<<<<.<<..<<<<<<<<....<<<.<<<
..<......>......<<.......<<<<.<..<<<.....>>>.>..>>
>>..<<<<....<<...<<<....>>>..>>......>>>>.<<...>>.
>>.<<<....>>>.....>>>>>>.........<<<....<<<<....>>
>>..>>>..>>.>>>>>>.....<<<<<<<<.....(((.....((.>>>
)).......)))..>>>>>..>>.>>>>>>....<<<((.....<<<<..
<<<<...............<<<<<<......<<<.<<<.<<<......>>
>..>>>.>>>.............<<....>>.>>>>>>.....>>>>...
>>>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>
..........<.<<<<<......))..>>>>>.>.>>>.<<.......<<
<<....>>>>.....>>..>>>>>><<<<<.<<<<<<<...<<<.<<<<<
..<<<<<<<<<<.....<<........>>..........<<<<<<<....
...<<.<<<..<<<<<<.......<<..<<<<<.....>>>.......>>
..>>.....<<<....>>>.........>>>...>>>>>>>>....>>>>
>>>..>>.>>>>>>>>.....<<<<.....>>>>.....<....<<<<<<
<.......>>>>>>>....>.....>>>>>.....<<<<<<<........
.>>>>>>>.....>>>...>>>>>>>>>>.>>....<..<<.<...<<<<
<<..<<<<<......<<<...<<<.....>>>..>>>.......>>>>>.
>>>>>>....>.>>...>.....<<<<<<<<<....>>>>>>>>>.....
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7qi4 Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications.
Resolution2.21 Å
Binding residue
(original residue number in PDB)
T91 L98 K100 G101 A104 T106 G107 A108 G109 K112 R114 R117 T118 K119 R136 R191 S194 G195 N196 R226 V228 F229 T230 M231 T232 A233 K234 E235 R237 R242 F256 K260 D266 R269 R297 F298 K299 R300 R315 C316 H317 R318 Y333 A334 K335 S339 I340 N341 L343 Q347 R351 W408 R419 V421 W422 S423 R427
Binding residue
(residue number reindexed from 1)
T4 L11 K13 G14 A17 T19 G20 A21 G22 K25 R27 R30 T31 K32 R49 R104 S107 G108 N109 R139 V141 F142 T143 M144 T145 A146 K147 E148 R150 R155 F169 K173 D179 R182 R210 F211 K212 R213 R228 C229 H230 R231 Y246 A247 K248 S252 I253 N254 L256 Q260 R264 W321 R332 V334 W335 S336 R340
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0032543 mitochondrial translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005763 mitochondrial small ribosomal subunit
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:1990904 ribonucleoprotein complex

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Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7qi4, PDBe:7qi4, PDBj:7qi4
PDBsum7qi4
PubMed38769321
UniProtP82675|RT05_HUMAN Small ribosomal subunit protein uS5m (Gene Name=MRPS5)

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