Structure of PDB 7p5x Chain AD Binding Site BS01

Receptor Information
>7p5x Chain AD (length=1265) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLDVNFFDELRIGLATADDIRNWSYGEVKKPETINYRTLKPEKDGLFCEK
IFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAP
VTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDDEMRHNELST
LEAEMAVEKKAVEDQRDADLEARAQKLEADLAELEAEGAKSDVRRKVRDS
GEREMRQLRDRAQRELDRLDEIWNTFTKLAPKQLIVDEVLYRELQDRYGE
YFTGAMGAESIKKLIENFDIDAEAESLREVIRSGKGQKKLRALKRLKVVA
AFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINR
NNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLK
SLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALE
LFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNR
APTLHRLGIQAFEPQLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAE
AQAEARILMLSSNNILSPASGKPLAMPRLDMVTGLYYLTTLVEGATGEYQ
AATKDAPEQGVYSSPAEAIMAMDRGALSVRAKIKVRLTELRPPTDLEAQL
FENGWKPGDAWTAETTLGRVMFNELLPKSYPFVNEQMHKKVQARIINDLA
ERFPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPQKQEILERHEA
EADAIERKYQRGALNHTERNESLVKIWQDATEEVGKALEEFYPADNPIIT
IVKSGATGNLTQTRTLAGMKGLVTNPKGEFIPRPIKSSFREGLTVLEYFI
NTHGARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCETERGINVTL
AERGPDGTLIRDAHVETSAFARTLATDAVDANGNVIIERGHDLGDPAIDA
LLAAGITTVKVRSVLTCTSATGVCAMCYGRSMATGKLVDIGEAVGIVAAQ
SIGEPGTQLTMRVGGLPRVQELFEARVPRNKAPIADVAGRVRLEESDKFF
KITIVPDDGGEEVVYDKLSKRQRLRVITHGVLSDGDHVEVGDQLMEGAAD
PHEVLRVQGPREVQIHLVKEVQEVYRAQGVSIHDKHIEVIVRQMLRRVTI
IDSGSTEFLPGSLTERAEFEAENRRVVAEGGEPAAGRPVLMGITKASLAT
DSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGISRY
RNIQVQPTEEARAAA
Ligand information
>7p5x Chain AO (length=43) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acttgtcggtggtctgctctaacgtcacggccaaccgatcgga
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7p5x Transcriptional control of mycobacterial DNA damage response by sigma adaptation.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		Y36 K294 R1039
Binding residue
(residue number reindexed from 1)		Y36 K294 R1026
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7p5x, PDBe:7p5x, PDBj:7p5x
PDBsum7p5x
PubMed34851662
UniProtA0QS66|RPOC_MYCS2 DNA-directed RNA polymerase subunit beta' (Gene Name=rpoC)

[Back to BioLiP]