Structure of PDB 6olz Chain AD Binding Site BS01

Receptor Information
>6olz Chain AD (length=294) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIV
RVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGL
LLARRLLNRFGMDKIYEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLART
TTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQN
VADYMRYLMEEDEDAYKKQFSQYIKNSVTPDMMEEMYKKAHAAIRENPVY
EKKPKKEVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
Ligand information
>6olz Chain A4 (length=119) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gucuacggccauaccacccugaacgcgcccgaucucgucugaucucggaa
gcuaagcagggucgggccugguuaguacuuggaugggagaccgccuggga
auaccgggugcuguaggcu
<<<<<<<<<....<<<<<<<<.....<<<<<..............>>>..
>>....>>>>>>.>><<<<<<<......<.<<..<<....>>.>>.>...
..>>>>>>>>>>>>>>>>.
Receptor-Ligand Complex Structure
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PDB6olz Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		F13 Y16 V18 F20 R21 R22 R24 K27 T28 Y30 R33 R54 T56 N57 R58 I61 D72 M73 I74 Y79 N94 Y95 T155 N157 K158 V204 Y207 F223 S224 Q225 Y226 Y253 K255 K256 K258 E260 K264 W266 N267 R268 K270 M271 K276 R279 V280
Binding residue
(residue number reindexed from 1)		F10 Y13 V15 F17 R18 R19 R21 K24 T25 Y27 R30 R51 T53 N54 R55 I58 D69 M70 I71 Y76 N91 Y92 T152 N154 K155 V201 Y204 F220 S221 Q222 Y223 Y250 K252 K253 K255 E257 K261 W263 N264 R265 K267 M268 K273 R276 V277
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0048027 mRNA 5'-UTR binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0002181 cytoplasmic translation
GO:0006364 rRNA processing
GO:0006412 translation
GO:0010628 positive regulation of gene expression
GO:0042273 ribosomal large subunit biogenesis
GO:0045727 positive regulation of translation
GO:0050821 protein stabilization
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1904667 negative regulation of ubiquitin protein ligase activity
GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process
GO:2000435 negative regulation of protein neddylation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0032991 protein-containing complex
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6olz, PDBe:6olz, PDBj:6olz
PDBsum6olz
PubMed31160784
UniProtP46777|RL5_HUMAN Large ribosomal subunit protein uL18 (Gene Name=RPL5)

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