Structure of PDB 7p5x Chain AC Binding Site BS01

Receptor Information
>7p5x Chain AC (length=1121) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLVGSDRWRQAAIDRGE
ENPVGGLEEVLAELSPIEDFSGSMSLSFSDPRFDEVKASVDECKDKDMTY
AAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQL
VRSPGVYFDETIDKSTEKTLHSVKVIPGRGAWLEFDVDKRDTVGVRIDRK
RRQPVTVLLKALGWTNEQIVERFGFSEIMMGTLEKDTTSGTDEALLDIYR
KLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLNAGKPIT
SSTLTEEDVVATIEYLVRLHEGQTSMTVPGGVEVPVEVDDIDHFGNRRLR
TVGELIQNQIRVGLSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKE
FFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSH
YGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVENGVVTDQID
YLTADEEDRHVVAQANSPTDENGRFTEDRVMVRKKGGEVEFVSADQVDYM
DVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTG
MELRAAIDAGDVVVADKTGVIEEVSADYITVMADDGTRQSYRLRKFARSN
HGTCANQRPIVDAGQRVEAGQVIADGPCTQNGEMALGKNLLVAIMPWEGH
NYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNVSDE
VLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKA
REVRDTSLKVPHGESGKVIGIRVFSREDDDELPAGVNELVRVYVAQKRKI
SDGDKLAGRHGNKGVIGKILPVEDMPFLPDGTPVDIILNTHGVPRRMNIG
QILETHLGWVAKAGWNIDVAAGVPDWASKLPEELYSAPADSTVATPVFDG
AQEGELAGLLGSTLPNRDGEVMVDADGKSTLFDGRSGEPFPYPVTVGYMY
ILKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAY
GAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQ
SLCLNVEVLSSDGAAIEMRDG
Ligand information
>7p5x Chain AO (length=43) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acttgtcggtggtctgctctaacgtcacggccaaccgatcgga
Receptor-Ligand Complex Structure
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PDB7p5x Transcriptional control of mycobacterial DNA damage response by sigma adaptation.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		R172 W202 R219 R389 R458
Binding residue
(residue number reindexed from 1)		R152 W182 R199 R369 R438
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0046677 response to antibiotic
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7p5x, PDBe:7p5x, PDBj:7p5x
PDBsum7p5x
PubMed34851662
UniProtP60281|RPOB_MYCS2 DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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