Structure of PDB 4v6i Chain AB Binding Site BS01

Receptor Information
>4v6i Chain AB (length=204) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VADGVFYAELNEFFTRELAEEGYSGVEVRVTPTKTEVIIRATRTQDVLGE
NGRRINELTLLVQKRFKYAPGTIVLYAERVQDRGLSAVAQAESMKFKLLN
GLAIRRAAYGVVRYVMESGAKGCEVVVSGKLRAARAKAMKFADGFLIHSG
QPVNDFIDTATRHVLMRQGVLGIKVKIMRDPAKSRTGPKALPDAVTIIEP
KEEE
Ligand information
>4v6i Chain CA (length=1721) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaaguuaagcca
ugcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcucau
uaaaucaguuaucguuuauuugauagacauggauaacugugguaauucua
gagcuaauacauguuaaaaucucgacccuuuggaagagauguauuuauua
gauaaaaaaucaaugucuucggacucuuugaugauucauaauaacuuuuc
gaaucgcauggccuugugcuggcgaugguucauucaaauuucugcccuau
caacuuuaugguaggauaguggccuaccaugguuucaacggguaacgggg
aauaaggguucgauuccggagagggagccugagaaacggcuaccacaucc
aaggaaggcagcaggcgcgcaaauuacccaauccuaauucagggagguag
ugacaauaaauaacgauacagggcccauucgggucuuguaauuggaauga
guacaauguaaauaccuuaacgaggaacaauuggagggcaagucuggugc
cagcagccgcgguaauuccagcuccaauagcguauauuaaaguuguugca
guuaaaaagcucguaguugaacuuugggcccgguuggccgguccgauuuu
uucguguacuggauuuccaacgggguccuucuggcuaaccuugaguccuu
guggcucuuggcgaaccaguguucaaagcaggcguauugcucgaauauac
guuugguucuauuuuguugguuucuaggaccaucguaauggggacggucg
ggggcaucaguauucaauugucagaggugaaauucuuggauuuauugaag
acuaacuacugcgaaagcauuugccaaggacguuuucauuaaucaagaac
gaaaguuaggggaucgaagaugaucagauaccgucguagucuuaaccaua
aacuaugccgacuagggaucgggugguguuuuuuuaaugacccacucggc
accuuagagaaaucaaagucuuuggguucuggggggaguauggucgcaag
gcugaaacuuaaaggaauugacggaagggcaccaccaggaguggagccug
cggcuuaauuugacucaacacggggaaacucaccagguccagacacaaua
aggauugacagauugagagcucuuucuugauuuugugggugguggugcau
ggccguucuuaguugguggagugauuugucugcuuaauugcgauaacgaa
cgagaccuuaaccuacuaaauaguggugcuagcauuugcugguuauccac
uucuuagagggacuaucgguuucaagccgauggaaguugaggcaauaaca
ggucugugaugcccuuaacguucugggcgcacgcgcgcuacacugacgga
gccagcgagucuaaccuuggccgagaggucuugguaaucuugugaaacuc
cgucgugcuggggauagagcauuguaauuauugcucuucaacgaggaauu
ccuaguaagcgcaagucaucagcuugcguugauuacgucccugcccuuug
uacacaccgcccgucgcuaguaccgauugaauggcuuagugaggccucag
gaucugcuuagagaagggggcaacuccaucucagagcggagaauuuggac
aaacuuggucauuuagaggaacuaaaagucguaacaagguuuccguaggu
gaaccugcggaaggaucauua
...<<<<<.[.((((>>>>><<<<..<<<<<...<...........<<<.
<<<...<...<<.....<............>....>>>.......<<...
.....<<<..<<..<<...........<<<<.....<<.<<<.....>>>
.>>......>>>>.<.<<<.........>>>.>....<.<<<<[......
((...((..<..<.....>..>.............>.]..>>>.>.....
<..<<<<.<<<<.....>>>>>>>>>.........>>>>..>>>.<<<..
..<<<..<<<<<<<.........>>>>>>>>>>......>>>...<<<<<
<<<....>>>>...>>>>.>>.<<.<<<..........>>>.>>.<.<<.
...>>.>...>>>>>>.......<.<<<...<<<<.....>>>.>>>>>.
.......>.....<<<<<<<<<<<<<....>>>>>>>>>>.>>>......
..............................<<<<<((......<<<<...
..<<..))>>.......>>>>.>>>>>..>>>>>.>>>>.........<<
<[[.....<.<<...<<<..............<..<.....<..<..<..
...>..>...>..>...>.......<...<.<<.<.<...<<..<....>
..>>...>.>.>>.>...>.<<.....<..<......>..>.....>>.<
...<<<<<<<<.....))...)).>>>>>>>>..>......<<<<<.<<.
..<<<<..<<<.<<<<<<.<...<<<......>>>......>.>>>>>>.
>>>......<<<....>>>..>>>>..>>.>>>.>>....>>>...>>.>
....<<<<<<<...<...<<<<.........>>>>...>>>>>>>>....
......<<<.<<.<<<..<<<<<<<<.<<<<.....>.>>>>>>>>>>>.
.>>>..<<.].]>>...>>.....>>>.>>>.<<<......<<<......
>>>....>>>..)))).]<<<<<.<<<<<<<...<..<<<<<..<<<.<<
<<<<......<..........>..........<<<<<........<<..<
<<....<<............>>........>>>..>>...<..<<<..<<
.<<<<<<....<<<.<<<<......>>...<<<......>>>...>>.>>
>......<<..<<<.<<<<..<<<<..<<<<<......>>>>>....>>>
>..>>>>>>>.....<<<<.......>>>>........>>......>>>.
>>>.....>>>>>.>......>>>>>..>>.>>>>.>>>.....<<<<<.
........<..........<<<....>>>..........>.........>
>>>>...........<<<<<<..........>>>>>>..........>>>
>>.....<<<<<<<<<.....>>>>>>>>>......>....>>>>>>>>>
>.>>.......<<.<..<<...<<....<<<<<<<<.<<<..<.<<....
..<<<<<<<.<<<<.<<<<....>>>>.>>>>.>>>>>>>......>>.>
..>>>.>>>>>>>>...>>...>>...>.>>.........<<<<<<<<<.
...>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4v6i Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolution.
Resolution8.8 Å
Binding residue
(original residue number in PDB)		S139 K141 R143 R146 A147 K151 F156 I158 S160 G161 Q162 H174 L176 R178 V181
Binding residue
(residue number reindexed from 1)		S128 K130 R132 R135 A136 K140 F145 I147 S149 G150 Q151 H163 L165 R167 V170
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0005515 protein binding
Biological Process
GO:0000054 ribosomal subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0070651 nonfunctional rRNA decay
GO:1990145 maintenance of translational fidelity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030686 90S preribosome
GO:0030688 preribosome, small subunit precursor
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4v6i, PDBe:4v6i, PDBj:4v6i
PDBsum4v6i
PubMed20980660
UniProtP05750|RS3_YEAST Small ribosomal subunit protein uS3 (Gene Name=RPS3)

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