Structure of PDB 8ph8 Chain AAA Binding Site BS01

Receptor Information
>8ph8 Chain AAA (length=129) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL
Ligand information
Ligand IDZJO
InChIInChI=1S/2C13H12N2.H2O.2Ru/c2*1-3-7-12(8-4-1)14-11-15-13-9-5-2-6-10-13;;;/h2*1-10H,11H2;1H2;;/q2*-2;;+2;+3/p-1
InChIKeyPDMORHSIDGQFCT-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7c1ccc(cc1)N2CN([Ru]3([Ru]2N(CN3c4ccccc4)c5ccccc5)O)c6ccccc6
CACTVS 3.385O[Ru]1N(CN([Ru]N(CN1c2ccccc2)c3ccccc3)c4ccccc4)c5ccccc5
FormulaC26 H25 N4 O Ru2
Name1-oxidanyl-2,4,6,8-tetraphenyl-2,4,6,8-tetraza-1$l^{4},5$l^{3}-diruthenabicyclo[3.3.0]octane
ChEMBL
DrugBank
ZINC
PDB chain8ph8 Chain AAA Residue 204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ph8 Steric hindrance and charge influence on the cytotoxic activity and protein binding properties of diruthenium complexes.
Resolution1.29 Å
Binding residue
(original residue number in PDB)		R5 K33 N37 F38
Binding residue
(residue number reindexed from 1)		R5 K33 N37 F38
Annotation score1
Enzymatic activity
Enzyme Commision number 3.2.1.17: lysozyme.
Gene Ontology
Molecular Function
GO:0003796 lysozyme activity
GO:0005515 protein binding
GO:0016231 beta-N-acetylglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0042802 identical protein binding
Biological Process
GO:0016998 cell wall macromolecule catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ph8, PDBe:8ph8, PDBj:8ph8
PDBsum8ph8
PubMed37660867
UniProtP00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)

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