Structure of PDB 8ofk Chain AAA Binding Site BS01

Receptor Information
>8ofk Chain AAA (length=300) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SQVTIKDIEVLNCEYGKNTIKFLRLHREGKKHFVKEVEVCTHLRLTSAHE
YLDGNNSFVIPTDTIKNIVLVLAKKNGISSIEQFAIDICKHFMTTFCQVA
YVKTYIQEVPWQRQYQNGVPHIHSFILVPDGIRFCEAEQCRNGPLVVCAG
IKDLKLMKTTQSGFEGFYRNEHTTLPERNDRILCGEFFCKWSYGECRDFD
FDCIWSKVRECILEAFSGPPDCGEYSPSYQRTVNCIQMCVLSRVPQVQVI
EVILNNNFYNVVDMKALGCTNDKEVLVPVETPYGSCACTLGRKKYLEAQS
Ligand information
Ligand IDAZA
InChIInChI=1S/C4H3N5O2/c10-3-1-2(8-9-7-1)5-4(11)6-3/h(H3,5,6,7,8,9,10,11)
InChIKeyKVGVQTOQSNJTJI-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O=C1NC(=O)c2nn[nH]c2N1
OpenEye OEToolkits 1.5.0c12c([nH]nn1)NC(=O)NC2=O
ACDLabs 10.04O=C2Nc1nnnc1C(=O)N2
FormulaC4 H3 N5 O2
Name8-AZAXANTHINE
ChEMBLCHEMBL219341
DrugBankDB01875
ZINCZINC000018123155
PDB chain8ofk Chain AAA Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8ofk Cysteine Enrichment Mediates Co-Option of Uricase in Reptilian Skin and Transition to Uricotelism.
Resolution1.713 Å
Binding residue
(original residue number in PDB)		F165 L176 R182 S229 Y230 Q231
Binding residue
(residue number reindexed from 1)		F164 L175 R181 S228 Y229 Q230
Annotation score2
Enzymatic activity
Enzyme Commision number 1.7.3.3: factor independent urate hydroxylase.
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0006144 purine nucleobase metabolic process
Cellular Component
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ofk, PDBe:8ofk, PDBj:8ofk
PDBsum8ofk
PubMed37695804
UniProtA0A8V0ZED1

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