Structure of PDB 7zu6 Chain AAA Binding Site BS01

Receptor Information

>7zu6 Chain AAA (length=129) Species: 9031 (Gallus gallus)

KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL

Ligand information

• Ligand ID: V4O
• InChI: InChI=1S/12O.4V/q;;;;;;;;4*-1;;;;
• InChIKey: ACTPEXQBEHJTBO-UHFFFAOYSA-N
• SMILES:
  OpenEye OEToolkits 1.7.2: [O-][V]1(=O)O[V](=O)(O[V](=O)(O[V](=O)(O1)[O-])[O-])[O-]
  CACTVS 3.370: [O-][V]1(=O)O[V]([O-])(=O)O[V]([O-])(=O)O[V]([O-])(=O)O1
• Formula: O12 V4
• Name: CYCLO-TETRAMETAVANADATE
• DrugBank: DB02147
• PDB chain: 7zu6 Chain AAA Residue 203

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7zu6 Polyoxidovanadate interaction with proteins. Binding of tetra-, penta-, hexa- and decavanadate to lysozyme
• Resolution: 1.183 Å
• Binding residue (original residue number in PDB): K1 S86
• Binding residue (residue number reindexed from 1): K1 S86
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0005515 protein binding
• GO:0016231 beta-N-acetylglucosaminidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0042802 identical protein binding

Biological Process

• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:7zu6, PDBe:7zu6, PDBj:7zu6
• PDBsum: 7zu6
• PubMed: 37768728
• UniProt: P00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)