Structure of PDB 7z4o Chain AAA Binding Site BS01

Receptor Information
>7z4o Chain AAA (length=514) Species: 11320 (Influenza A virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ERFEITGTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKE
VNARIEPFLRTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGI
PLYDAIKCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIENEE
KIPRTKNMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPRS
LACWIQSEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVSH
CRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYG
FIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRT
AVGQVSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSV
KEKDLTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYAS
PQLEGFSAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLL
NASWFNSFLTHALR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7z4o Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD.
Resolution3.412 Å
Binding residue
(original residue number in PDB)		A287 L288 K289 L290 T313 R454 L527 M548 L550 V557 R559
Binding residue
(residue number reindexed from 1)		A85 L86 K87 L88 T111 R252 L325 M346 L348 V355 R357
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Biological Process
GO:0039694 viral RNA genome replication

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7z4o, PDBe:7z4o, PDBj:7z4o
PDBsum7z4o
PubMed35605026
UniProtM9TI86

[Back to BioLiP]