Structure of PDB 7p7w Chain AAA Binding Site BS01

Receptor Information
>7p7w Chain AAA (length=304) Species: 559292,1315976 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GTMYYGFDIGGTKIEFGAFDADLVRVARERVATPTESYAAFLDAIVTLVN
NADAEFGVKGTVGIGIPGIADVETGKLLTSNIPAAMGHTLQRDLEERLQR
PVKIENDANCFALSEAWDEDLRGEPSVLGLILGTGVGGGLIFNGKVHSGR
ANIAGEIGHTRLPYDALKLLGMENAPIFPCGCKNSGCIDNYLSGRGFEQL
YDHYFSEKLSAPEIIAHYEQGERRAVQHVERFMELLAICLANIFTCLDPH
VVVLGGGLSNFELIYQELPKRLPAHLLHVAKLPKIIKARHGDAGGVRGAA
FLNL
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain7p7w Chain AAA Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7p7w Structure and function of N-acetylglucosamine kinase illuminates the catalytic mechanism of ROK kinases
Resolution1.57 Å
Binding residue
(original residue number in PDB)		G8 G9 T10 G131 T132 G192 E196 G254 G255 N258
Binding residue
(residue number reindexed from 1)		G10 G11 T12 G133 T134 G194 E198 G256 G257 N260
Annotation score5
Enzymatic activity
Enzyme Commision number 2.7.1.59: N-acetylglucosamine kinase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016301 kinase activity
GO:0031386 protein tag activity
GO:0042802 identical protein binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0045127 N-acetylglucosamine kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006044 N-acetylglucosamine metabolic process
GO:0009254 peptidoglycan turnover
GO:0016310 phosphorylation
GO:0016925 protein sumoylation
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0005634 nucleus
GO:0005940 septin ring

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7p7w, PDBe:7p7w, PDBj:7p7w
PDBsum7p7w
PubMed
UniProtQ12306|SMT3_YEAST Ubiquitin-like protein SMT3 (Gene Name=SMT3);
R8APY9

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