Structure of PDB 6z4v Chain AAA Binding Site BS01

Receptor Information
>6z4v Chain AAA (length=456) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NSDLDVNTDIYSKVLVTAIYLALFVVGTVGNGVTLFTLARKRVDYYLGSL
ALSDLLILLFALPVELYNFIWVHHPWAFGDAGCKGYYFLRDACTYATALN
VVSLSVELYLAICRTKKFISAIWLASALLAIPMLFTMGLQNLSGDGTHPG
GLVCTPIVDTATLRVVIQLNTFMSFLFPMLVASILNTVAARRLTVMVHQA
AFNMTIEPGRVQALRRGVLVLRAVVIAFVVCWLPYHVRRLMFVYISDEQW
TTALFDFYHYFYMLSNALFYVSSAINPILYNLAEDLVEDWEKARKLLEAA
RKGQDDEVRILLANGADVNTADETGFTPLHLAAWEGHLGIVEVLLKNGAD
VNANDERGHTPLHLAAYTGHLEIVEVLLKNGAGVNATDVIGTAPLHLAAM
WGHLEIVEVLLKNGADVNAQDKFGKTPFDLAIDNGNEDIAEVLQKAATRE
LEVLFQ
Ligand information
Receptor-Ligand Complex Structure
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PDB6z4v Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Resolution2.595 Å
Binding residue
(original residue number in PDB)		L55 F128 H132 Y146 V224 T226 R327 R328 F331 S335 W339 F344 Y347
Binding residue
(residue number reindexed from 1)		L4 F69 H73 Y87 V153 T155 R238 R239 F242 S246 W250 F255 Y258
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016492 G protein-coupled neurotensin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6z4v, PDBe:6z4v, PDBj:6z4v
PDBsum6z4v
PubMed33571132
UniProtP20789|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)

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