Structure of PDB 6xxf Chain AAA Binding Site BS01

Receptor Information

TEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINE
VDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAE
LRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK

Ligand information

KKAVWHKLLSKQRKRAVVACF

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

PDB	6xxf CPVT-associated calmodulin variants N53I and A102V dysregulate Ca2+ signalling via different mechanisms.
Resolution	1.7 Å
Binding residue (original residue number in PDB)	E12 E15 F20 M37 S39 L40 M52 E55 F69 M72 M73 K76 M77 E85 L113 G114 E115 E124 M125 E128 M145 M146 A148 K149
Binding residue (residue number reindexed from 1)	E7 E10 F15 M32 S34 L35 M47 E50 F64 M67 M68 K71 M72 E80 L108 G109 E110 E119 M120 E123 M140 M141 A143 K144

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0010856	adenylate cyclase activator activity
GO:0019855	calcium channel inhibitor activity
GO:0019901	protein kinase binding
GO:0031432	titin binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0044325	transmembrane transporter binding
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0072542	protein phosphatase activator activity

	Biological Process
GO:0000086	G2/M transition of mitotic cell cycle
GO:0002027	regulation of heart rate
GO:0005513	detection of calcium ion
GO:0007186	G protein-coupled receptor signaling pathway
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0010801	negative regulation of peptidyl-threonine phosphorylation
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0021762	substantia nigra development
GO:0031954	positive regulation of protein autophosphorylation
GO:0032465	regulation of cytokinesis
GO:0050848	regulation of calcium-mediated signaling
GO:0051343	positive regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051592	response to calcium ion
GO:0055117	regulation of cardiac muscle contraction
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0140238	presynaptic endocytosis
GO:1901020	negative regulation of calcium ion transmembrane transporter activity
GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction
GO:1905913	negative regulation of calcium ion export across plasma membrane

	Cellular Component
GO:0000922	spindle pole
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005819	spindle
GO:0005856	cytoskeleton
GO:0005876	spindle microtubule
GO:0005886	plasma membrane
GO:0008076	voltage-gated potassium channel complex
GO:0016020	membrane
GO:0030017	sarcomere
GO:0031982	vesicle
GO:0032991	protein-containing complex
GO:0034704	calcium channel complex
GO:0043209	myelin sheath
GO:0044305	calyx of Held
GO:0097225	sperm midpiece
GO:0099523	presynaptic cytosol
GO:1902494	catalytic complex

External links

PDB	RCSB:6xxf, PDBe:6xxf, PDBj:6xxf
PDBsum	6xxf
PubMed	34888671
UniProt	P0DP24\|CALM2_HUMAN Calmodulin-2 (Gene Name=CALM2)