Structure of PDB 6tt5 Chain AAA Binding Site BS01

Receptor Information

>6tt5 Chain AAA (length=348) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SFEGQMAEYPTISIDRFDRENLRARAYFLSHCHKDHMKGLRAPTLKRRLE
CSLKVYLYCSPVTKELLLTSPKYRFWKKRIISIEIETPTQISLVDESGEK
EEIVVTLLPAGHCPGSVMFLFQGNNGTVLYTGDFRLAQGEAARMELLHSG
GRVKDIQSVYLDTTFCDPRFYQIPSREECLSGVLELVRSWITRSPYHVVW
LNCKAAYGYEYLFTNLSEELGVQVHVNKLDMFRNMPEILHHLTTDRNTQI
HACRHKLPCGITSRNRIPLHIISIKPSTMWFGERSRKTNVIVRTGESSYR
ACFSFHSSYSEIKDFLSYLCPVNAYPNVIPVGTTMDKVVEILKPLCRS

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

6tt5 Chain AAA Residue 407 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6tt5 Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Resolution	1.5 Å
Binding residue (original residue number in PDB)	H228 H254 C256 C272
Binding residue (residue number reindexed from 1)	H225 H251 C253 C259
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.1.-.-

External links

PDB	RCSB:6tt5, PDBe:6tt5, PDBj:6tt5
PDBsum	6tt5
PubMed	34387696
UniProt	Q96SD1\|DCR1C_HUMAN Protein artemis (Gene Name=DCLRE1C)

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