Structure of PDB 6tg8 Chain AAA Binding Site BS01
Receptor Information
>6tg8 Chain AAA (length=288) Species:
9606
(Homo sapiens) [
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PKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVG
GLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVI
DGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL
LYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYA
AGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG
YDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
Ligand information
>6tg8 Chain PPP (length=11) Species:
9606
(Homo sapiens) [
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VINPETGEQIQ
Receptor-Ligand Complex Structure
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PDB
6tg8
Binding of dipeptidyl peptidase III to the oxidative stress cell sensor Kelch-like ECH-associated protein 1 is a two-step process.
Resolution
2.75 Å
Binding residue
(original residue number in PDB)
Y334 S363 R380 N382 R415 R483 S508 G509 Y525 Q530 S555 Y572 F577 S602
Binding residue
(residue number reindexed from 1)
Y13 S42 R59 N61 R94 R162 S187 G188 Y204 Q209 S234 Y251 F256 S281
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6tg8
,
PDBe:6tg8
,
PDBj:6tg8
PDBsum
6tg8
PubMed
32811353
UniProt
Q14145
|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Gene Name=KEAP1)
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