Structure of PDB 6ss4 Chain AAA Binding Site BS01

Receptor Information
>6ss4 Chain AAA (length=316) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDL
SFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHS
LAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLREL
QDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRD
IDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGL
TYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIAS
SFGQTREGGHIVYDQL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6ss4 Chain AAA Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ss4 Structural and functional characterization of C0021158, a high-affinity monoclonal antibody that inhibits Arginase 2 function via a novel non-competitive mechanism of action.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		H120 D143 D147 D251
Binding residue
(residue number reindexed from 1)		H99 D122 D126 D230
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.3.1: arginase.
Gene Ontology
Molecular Function
GO:0004053 arginase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0000050 urea cycle
GO:0001657 ureteric bud development
GO:0002250 adaptive immune response
GO:0002829 negative regulation of type 2 immune response
GO:0006525 arginine metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006941 striated muscle contraction
GO:0019547 arginine catabolic process to ornithine
GO:0032651 regulation of interleukin-1 beta production
GO:0032696 negative regulation of interleukin-13 production
GO:0032700 negative regulation of interleukin-17 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0045087 innate immune response
GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production
GO:0071644 negative regulation of chemokine (C-C motif) ligand 4 production
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production
GO:1900425 negative regulation of defense response to bacterium
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1905403 negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation
GO:2000774 positive regulation of cellular senescence
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ss4, PDBe:6ss4, PDBj:6ss4
PDBsum6ss4
PubMed32880207
UniProtP78540|ARGI2_HUMAN Arginase-2, mitochondrial (Gene Name=ARG2)

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