Structure of PDB 8oeq Chain AA Binding Site BS01

Receptor Information
>8oeq Chain AA (length=135) Species: 5476 (Candida albicans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AKFIKSGKVAIVVRGRYAGKKVVIVKPHDEGTKSHPFPHAIVAGIERAPL
KVTKKMDAKKVTKRTKVKPFVKLVNYNHLMPTRYSLDVESFKSAVTSEAL
EEPSQREEAKKVVKKAFEEKHQAGKNKWFFQKLHF
Ligand information
>8oeq Chain 1 (length=3217) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ugaccucaaaucagguaggacuacccgcugaacuuaagcauaucaauaag
cggaggaaaagaaaccaacagggauugccucaguagcggcgagugaagcg
gcaaaagcucaaauuugaaaucuggcgucuuuggcguccgaguuguaauu
ugaagaagguaucuuugggcccggcucuugucuauguuccuuggaacagg
acgucacagagggugagaaucccgugcgaugagaugacccgggucugugu
aaaguuccuucgacgagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcuugagaucagacuugguauuuugca
ugcugcgguuuaccgggccagcaucgguuuggagcggcaggauaauggcg
gaggaauguggcacggcuucugcuguguguuauagccucugacgauacug
ccagccuagaccgaggacugcgguuuaccuaggauguuggcauaaugauc
uuaagucgcccgucuugaaacacggaccaaggagucuaacgucuaugcga
guguuuggguguaaaacccguacgcguaaugaaagugaacgaaggugggg
gcccauuagggugcaccaucgaccgauccugauguguucggauggauuug
aguaagagcauagcuguugggacccgaaagauggugaacuaugccugaau
agggugaagccagaggaaacucugguggaggcucguagcgguucugacgu
gcaaaucgaucgucgaauuuggguauaggggcgaaagacuaaucgaacca
ucuaguagcugguuccugccgaaguuucccucaggauagcagaagcucgu
aucaguuuuaugagguaaagcgaaugauuagaagucuugggguugaaaug
accuuaacuuauucucaaacuuuaaauauguaagaaguccuuguugcuua
auugaacguggacaauugaaugaagagcuuuuagugggccauuuuuggua
agcagaacuggcgaugcgggaugaaccgaacgugaaguuaaagugccgga
augcacgcucaucagacaccacaaaagguguuaguucaucuagacagccg
gacgguggccauggaagucggaauccgcuaaggaguguguaacaacucac
cggccgaaugaacuagcccugaaaauggauggcgcucaagcgugcuacuu
auacuucaccgugauugcuguuuugacgcuuucacgaguaggcaggcgug
gaggucagugacgaagccuuugcuguaaagcugggucgaacggccucuag
ugcagaucuuggugguaguagcaaauauucaaaugagaacuuugaagacu
gaaguggggaaagguuccaugucaacagcaguuggacauggguuagucga
uccuaagagauggggaagcuccguuucaacgugcuugauuuuucaggcca
accaucgaaagggaauccgguuaaaauuccggaacuuggauauggauucu
ucacggcaacguaacugaauguggagacgucggcgugagcccugggagga
guuaucuuuucuucuuaacagcuuaucacccuggaauugguuuauccgga
gauggggucuuauggcuggaagagcgcgguaauuuugccgcguccggugc
gcuuacgacgguccuugaaaauccacaggaaggaauaguuuucaugccaa
gucguacucauaaccgcagcaggucuccaagguuaacagccucuaguuga
uagaauaauguagauaagggaagucggcaaaauagauccguaacuucggg
auaaggauuggcucuaaggaucgguuuaacgaucaacuuagaacugguac
ggacaaggggaaucugacugucuaauuaaaacauagcauugugaugguca
gaaagugauguugacacaaugugauuucugcccagugcucugaaugucaa
agugaagaaauucaaccaagcgcggguaaacggcgggaguaacuaugacu
cucuuaagguagccaaaugccucgucaucuaauuagugacgcgcaugaau
ggauuaacgagauucccacugucccuaucuacuaucuagcgaaaccacag
ccaagggaacgggcuuggcagaaucagcggggaaagaagacccuguugag
cuugacucuaguuugacauugugaaaagacauggaggguguagaauaagu
gggagcuucggcgccggugaaauaccacuaccucuauaguuuuuuuacuu
auucaaugaagcggagcuggaggucaaacuccacguucuagcauuaagcc
cucugggcgauccggguugaagacauugucagguggggaguuuggcuggg
gcggcacaucuguuaaacgauaacgcagguguccuaagggggacucaugg
agaacagaaaucuccaguagaacaaaaggguaaaaguccccuugauuuug
auuuucagugugaauacaaaccaugaaaguguggccuaucgauccuuuag
ucccucggaauuugaggcuagaggugccagaaaaguuaccacagggauaa
cuggcuuguggcagucaagcguucauagcgacauugcuuuuugauucuuc
gaugucggcucuuccuaucauaccgaagcagaauucgguaagcguuggau
uguucacccacuaauagggaacgugagcuggguuuagaccgucgugagac
agguuaguuuuacccuacugaugaauguuaucgcaauaguaauugaacuu
aguacgagaggaaccguucauucagauaauugguuuuugcggcugucuga
ucaggcaacgccgcgaagcuaccaucugcuggauuauggcugaacgccuc
uaagucagaauccaugcuagaacgcgaugauuuuugcccugcacauuuua
gauggauacgaauaagacuuuagucgcuggaccauagcaggcuggcaacg
gugcgcuuagcggaaaggcuuugugcgcuugccggcggauagcaauguca
acaugcgcggggauaaauccuuugcauacgacuuagauguacaacggagu
auuguaagcaguagaguagccuuguuguuacgaucugcugagauuaagcu
cuuguugucugauuugu
.......................<<<<<<.....<......>......>>
>>>.>...{.....<<....>>..<<<<<......<.......>.....>
>>>>..[[[...........<<.<<<<<<...>>>>>>.>>.........
....<<<<<...<<<<<<<<<<<<.<<<<<<<.....<<<<......>>>
>.(.......<<<......)>>>....>>>>>>>....>>>>>>>>....
>>>>..>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]....}..........................
...<<....>>...............<<<<....>>>>............
......................<<<<<<<<<<<<.....<<<<.<.<...
......>>.>.>>>..<<<<<<<.<<<<<<<<.<<<<<<<....<<.<<<
<<<<......<<<<<<......>>>>>>.......>>>>>>.>.>>.>>>
>>.>>>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>
>>>>>>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..
<<<..<<<<<.....>>>>>..>>>...<<....>>.......<<<<<..
<<<<....>>>>...>>>>>.<<<<<<<<<..<<....>>>..>>>.>>>
.>>....>>>>>>.>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<.
.<<<....<<<<<<<....>>>>>>>.....>>>...<<<<.<<.<<...
.....>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>
>>...>..>.>>..<<<<<<....<.<<<....>>>.><<<<<<<<<<..
.<<<.<<<<<<<.....<<<....<<<....<<<<...<<<<<<.....>
>>>>>.>>>>....>>>..>.>>.....>>>>>...<<<<.<<<<.<...
...>>>>>.>>>>.....>>>>>.>>>>>>>>.>>..<<<<.<<<<<...
..>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<<(((...
..<<<<<<.....<<..........<<<.<<<<<<<<<<.......<<<<
<.<<<...<<.........>>...>>>.........<<......>>...>
>>>>...>>>>>>>>>>>>>..........))).>>...>>>>>>.>>>>
..>>>>>>><<<<<..<<.........>>..>>>>>....>>>>>><.<<
<<<<<<.<<......<<<<..<<<....>>>.>>>>...>>>>>>>>>>.
.>.....>>>>>><<.....<<.....<<<<<<.......>>>>>><<<<
.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<
<<<...<<....<<<....>>>..........<<<<<<....>>>>>>..
....>>....>>>..<<<<<........>>>>>))<<<<.<<<<<<<...
..<<<....>>>.......<<<<<<...<<<<.<<<<<<<.<<<<<<<<<
<..{{{..>>>>>><...<<<<<....<<<<<<....<<<.....>>>..
..>>>>>>.....>>>>>....><<<<<<<......>>>>>>>>>>>...
>>>>>>>.>>>>.........>>>>>>..........>>>..>>>>>>>>
.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..
<<<<.....<<<<<<<.<<.........<.....<<<<<...........
....>>>>><<.<<<<<<<<<<<......>>>>>..>>>>>>.>>.....
.......<<<<<<<<<..<<<.........>>>..<<<<<<<....<<<<
.....>>>>......>>>>>>>...<<..<<<..<<<<<<....<<<...
..<<<<....>>>>.....>>>.>>>>..>>>>><<<<<<.......>>>
>>>........<...........<<<<<.......>>>>>.....>....
.>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>....>>....
<<<<<........>>>>>....[[[[[..{{{.{{......[[[[.{{[[
[[..<<<<<.<<<<<<<<..<<<<<<<<<<...<.<<.............
...............................>>.>...>>>>>>>>>>..
.<<<<<.....<<<<..<<<<<......>>>>>..............<<<
<...>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<...
..>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...<<<
<<<.......>>>>>>.....<<...(((>>....>>>>>>>...<<<.<
<<<<.......>>>>.>>>>.<<<....>>>.>>))).......((((((
..((((.>>>>>>))))))))))..........]]]]..}}]]]].....
..<<.<...<<<<<<...<<.......>>...>>>>>>....>.>.>...
....<<<<<.<<<<<<..<.<<<<<<<......>>>>>>>...>.<<<..
.......>>>.....>>>>>..>...>>>.>>....<<<<<<<....>>>
.>>>>....}}..}}}.]]]]]....<<<<<<<<..<<<<...<<<<<..
...............>>>>>..<<<<<...<<<<....<<<<<<<<<<}}
}.>>>>>..>>>>>...>>>>..>>>>>.<<<<...<<<<<.........
..>>>>>...>>>>.>>>>....>>>>>>>>.....<<<<<<.<<<....
...<<..........<<<<..>>>>......>>.......<<<<<<...<
<<<<<<..<<<......>>>..>>>>>>>.>>>>>>..............
..>>>.>>>>>>..<<<<<<<.............>>....<<<<<<<<<.
<<<....<<<<.<..<<<<<......>>>>>..>>>>>...>>>....>>
>>.>>>>>..>>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8oeq Drug-induced rotational movement of the ribosome is a key factor for read-through enhancement
Resolution3.3 Å
Binding residue
(original residue number in PDB)
R15 G16 R17 H36 F38 R48 T54 K55 K61 K64 K69 K73 L74 N76 H79 R107 K111 K112 K115 K133 H135 F136
Binding residue
(residue number reindexed from 1)
R14 G15 R16 H35 F37 R47 T53 K54 K60 K63 K68 K72 L73 N75 H78 R106 K110 K111 K114 K132 H134 F135
External links
PDB RCSB:8oeq, PDBe:8oeq, PDBj:8oeq
PDBsum8oeq
PubMed
UniProtQ9P843|RL27_CANAX Large ribosomal subunit protein eL27 (Gene Name=RPL27)

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