Structure of PDB 7qns Chain AA Binding Site BS01

Receptor Information

>7qns Chain AA (length=222) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DLPKSVDWRKKGYVTPVKNQKQCGSSWAFSATGALEGQMFRKTGKLVSLS
EQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICK
YRPENSVAQDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKS
GIYFEPDCSSKNLDHGVLVVGYGFEGANSQNSKYWLVKNSWGPEWGSNGY
VKIAKDKNNHCGIATAASYPNV

Ligand information

>7qns Chain PC (length=6) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

VYEKKP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7qns Peptide VYEKKP in complex with human cathepsin V C25S mutant
Resolution	1.4 Å
Binding residue (original residue number in PDB)	F147 Y148 K149 S150 I152 G196
Binding residue (residue number reindexed from 1)	F147 Y148 K149 S150 I152 G196

Enzymatic activity

Enzyme Commision number

3.4.22.43: cathepsin V.

Gene Ontology

	Molecular Function
GO:0008234	cysteine-type peptidase activity

	Biological Process
GO:0006508	proteolysis

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Molecular Function

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Biological Process

External links

PDB	RCSB:7qns, PDBe:7qns, PDBj:7qns
PDBsum	7qns
PubMed
UniProt	O60911\|CATL2_HUMAN Cathepsin L2 (Gene Name=CTSV)

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